UNPKG

molstar

Version:

A comprehensive macromolecular library.

232 lines (231 loc) 9.97 kB
/** * Copyright (c) 2017-2021 mol* contributors, licensed under MIT, See LICENSE file for more info. * * @author David Sehnal <david.sehnal@gmail.com> * @author Alexander Rose <alexander.rose@weirdbyte.de> */ import { Interval, Segmentation, SortedArray } from '../../../../../mol-data/int'; import { AtomicIndex, AtomicHierarchy } from '../atomic/hierarchy'; import { cantorPairing } from '../../../../../mol-data/util'; function getResidueId(seq_id, ins_code) { if (!ins_code) return seq_id; if (ins_code.length === 1) return cantorPairing(ins_code.charCodeAt(0), seq_id); if (ins_code.length === 2) return cantorPairing(ins_code.charCodeAt(0), cantorPairing(ins_code.charCodeAt(1), seq_id)); return `${seq_id} ${ins_code}`; } function updateMapMapIndex(map, key0, key1, index) { if (map.has(key0)) { const submap = map.get(key0); if (!submap.has(key1)) { submap.set(key1, index); } } else { const submap = new Map(); map.set(key0, submap); submap.set(key1, index); } } function missingEntity(k) { throw new Error(`Missing entity entry for entity id '${k}'.`); } function createMapping(entities, data, segments) { return { entities, segments, label_seq_id: SortedArray.ofSortedArray(data.residues.label_seq_id.toArray({ array: Int32Array })), label_atom_id: data.atoms.label_atom_id, auth_atom_id: data.atoms.auth_atom_id, label_alt_id: data.atoms.label_alt_id, type_symbol: data.atoms.type_symbol, chain_index_entity_index: new Int32Array(data.chains._rowCount), entity_index_label_asym_id: new Map(), chain_index_label_seq_id: new Map(), auth_asym_id_auth_seq_id: new Map(), chain_index_auth_seq_id: new Map(), label_asym_id: new Map(), }; } const _tempResidueKey = AtomicIndex.EmptyResidueKey(); class Index { getEntityFromChain(cI) { return this.map.chain_index_entity_index[cI]; } findEntity(label_asym_id) { const entityIndex = this.map.label_asym_id.get(label_asym_id); return entityIndex !== undefined ? entityIndex : -1; } findChainLabel(key) { const eI = this.entityIndex(key.label_entity_id); if (eI < 0 || !this.map.entity_index_label_asym_id.has(eI)) return -1; const cm = this.map.entity_index_label_asym_id.get(eI); if (!cm) return -1; return cm.has(key.label_asym_id) ? cm.get(key.label_asym_id) : -1; } findChainAuth(key) { if (!this.map.auth_asym_id_auth_seq_id.has(key.auth_asym_id)) return -1; const rm = this.map.auth_asym_id_auth_seq_id.get(key.auth_asym_id); return rm.has(key.auth_seq_id) ? rm.get(key.auth_seq_id) : -1; } findResidue(label_entity_id_or_key, label_asym_id, auth_seq_id, pdbx_PDB_ins_code) { let key; if (arguments.length === 1) { key = label_entity_id_or_key; } else { _tempResidueKey.label_entity_id = label_entity_id_or_key; _tempResidueKey.label_asym_id = label_asym_id; _tempResidueKey.auth_seq_id = auth_seq_id; _tempResidueKey.pdbx_PDB_ins_code = pdbx_PDB_ins_code; key = _tempResidueKey; } const cI = this.findChainLabel(key); if (cI < 0) return -1; const rm = this.map.chain_index_auth_seq_id.get(cI); const id = getResidueId(key.auth_seq_id, key.pdbx_PDB_ins_code || ''); return rm.has(id) ? rm.get(id) : -1; } findResidueLabel(key) { const cI = this.findChainLabel(key); if (cI < 0) return -1; const rm = this.map.chain_index_label_seq_id.get(cI); const id = getResidueId(key.label_seq_id, key.pdbx_PDB_ins_code || ''); return rm.has(id) ? rm.get(id) : -1; } findResidueAuth(key) { const cI = this.findChainAuth(key); if (cI < 0) return -1; const rm = this.map.chain_index_auth_seq_id.get(cI); const id = getResidueId(key.auth_seq_id, key.pdbx_PDB_ins_code || ''); return rm.has(id) ? rm.get(id) : -1; } findResidueInsertion(key) { const cI = this.findChainLabel(key); if (cI < 0) return -1; const rm = this.map.chain_index_label_seq_id.get(cI); const id = getResidueId(key.label_seq_id, key.pdbx_PDB_ins_code || ''); if (rm.has(id)) return rm.get(id); const idx = SortedArray.findPredecessorIndex(this.map.label_seq_id, key.label_seq_id); const start = AtomicHierarchy.chainStartResidueIndex(this.map.segments, cI); if (idx < start) return start; const end = AtomicHierarchy.chainEndResidueIndexExcl(this.map.segments, cI) - 1; if (idx >= end) return end; return idx; } findAtom(key) { const rI = this.findResidue(key); if (rI < 0) return -1; if (typeof key.label_alt_id === 'undefined') { return findAtomByName(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.label_atom_id, key.label_atom_id); } return findAtomByNameAndAltLoc(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.label_atom_id, this.map.label_alt_id, key.label_atom_id, key.label_alt_id); } findAtomAuth(key) { const rI = this.findResidueAuth(key); if (rI < 0) return -1; if (typeof key.label_alt_id === 'undefined') { return findAtomByName(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.auth_atom_id, key.auth_atom_id); } return findAtomByNameAndAltLoc(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.auth_atom_id, this.map.label_alt_id, key.auth_atom_id, key.label_alt_id); } findAtomOnResidue(rI, label_atom_id, label_alt_id) { if (typeof label_alt_id === 'undefined') { return findAtomByName(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.label_atom_id, label_atom_id); } return findAtomByNameAndAltLoc(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.label_atom_id, this.map.label_alt_id, label_atom_id, label_alt_id); } findAtomsOnResidue(rI, label_atom_ids) { return findAtomByNames(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.label_atom_id, label_atom_ids); } findElementOnResidue(rI, type_symbol) { return findAtomByElement(this.residueOffsets[rI], this.residueOffsets[rI + 1], this.map.type_symbol, type_symbol); } constructor(map) { this.map = map; this.entityIndex = map.entities.getEntityIndex; this.residueOffsets = this.map.segments.residueAtomSegments.offsets; } } function findAtomByName(start, end, data, atomName) { for (let i = start; i < end; i++) { if (data.value(i) === atomName) return i; } return -1; } function findAtomByNames(start, end, data, atomNames) { for (let i = start; i < end; i++) { if (atomNames.has(data.value(i))) return i; } return -1; } function findAtomByNameAndAltLoc(start, end, nameData, altLocData, atomName, altLoc) { for (let i = start; i < end; i++) { if (nameData.value(i) === atomName && altLocData.value(i) === altLoc) return i; } return -1; } function findAtomByElement(start, end, data, typeSymbol) { for (let i = start; i < end; i++) { if (data.value(i) === typeSymbol) return i; } return -1; } export function getAtomicIndex(data, entities, segments) { const map = createMapping(entities, data, segments); const { label_seq_id, auth_seq_id, pdbx_PDB_ins_code } = data.residues; const { label_entity_id, label_asym_id, auth_asym_id } = data.chains; const atomSet = Interval.ofBounds(0, data.atoms._rowCount); const chainsIt = Segmentation.transientSegments(segments.chainAtomSegments, atomSet); while (chainsIt.hasNext) { const chainSegment = chainsIt.move(); const chainIndex = chainSegment.index; const entityIndex = entities.getEntityIndex(label_entity_id.value(chainIndex)); if (entityIndex < 0) missingEntity(label_entity_id.value(chainIndex)); map.chain_index_entity_index[chainIndex] = entityIndex; const authAsymId = auth_asym_id.value(chainIndex); let auth_asym_id_auth_seq_id = map.auth_asym_id_auth_seq_id.get(authAsymId); if (!auth_asym_id_auth_seq_id) { auth_asym_id_auth_seq_id = new Map(); map.auth_asym_id_auth_seq_id.set(authAsymId, auth_asym_id_auth_seq_id); } const labelAsymId = label_asym_id.value(chainIndex); if (!map.label_asym_id.has(labelAsymId)) map.label_asym_id.set(labelAsymId, entityIndex); updateMapMapIndex(map.entity_index_label_asym_id, entityIndex, labelAsymId, chainIndex); const chain_index_label_seq_id = new Map(); const chain_index_auth_seq_id = new Map(); map.chain_index_label_seq_id.set(chainIndex, chain_index_label_seq_id); map.chain_index_auth_seq_id.set(chainIndex, chain_index_auth_seq_id); const residuesIt = Segmentation.transientSegments(segments.residueAtomSegments, atomSet, chainSegment); while (residuesIt.hasNext) { const residueSegment = residuesIt.move(); const rI = residueSegment.index; const authSeqId = auth_seq_id.value(rI); const insCode = pdbx_PDB_ins_code.value(rI); chain_index_label_seq_id.set(getResidueId(label_seq_id.value(rI), insCode), rI); chain_index_auth_seq_id.set(getResidueId(authSeqId, insCode), rI); auth_asym_id_auth_seq_id.set(authSeqId, chainIndex); } } return new Index(map); }