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molstar

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A comprehensive macromolecular library.

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/** * Copyright (c) 2017-2022 mol* contributors, licensed under MIT, See LICENSE file for more info. * * @author David Sehnal <david.sehnal@gmail.com> * @author Alexander Rose <alexander.rose@weirdbyte.de> */ import { __assign } from "tslib"; import { Column, Table } from '../../../mol-data/db'; import { Interval, Segmentation } from '../../../mol-data/int'; import { toDatabase } from '../../../mol-io/reader/cif/schema'; import { SymmetryOperator } from '../../../mol-math/geometry'; import { Mat4, Vec3 } from '../../../mol-math/linear-algebra'; import { AtomSiteOperatorMappingSchema } from '../../../mol-model/structure/export/categories/atom_site_operator_mapping'; import { AtomsSchema, ChainsSchema, ResiduesSchema } from '../../../mol-model/structure/model/properties/atomic'; import { getAtomicDerivedData } from '../../../mol-model/structure/model/properties/utils/atomic-derived'; import { getAtomicIndex } from '../../../mol-model/structure/model/properties/utils/atomic-index'; import { ElementSymbol } from '../../../mol-model/structure/model/types'; import { UUID } from '../../../mol-util/uuid'; import { MmcifFormat } from '../mmcif'; function findHierarchyOffsets(atom_site) { if (atom_site._rowCount === 0) return { residues: [], chains: [] }; var start = 0, end = atom_site._rowCount; var residues = [start], chains = [start]; var label_entity_id = atom_site.label_entity_id, label_asym_id = atom_site.label_asym_id, label_seq_id = atom_site.label_seq_id, auth_seq_id = atom_site.auth_seq_id, pdbx_PDB_ins_code = atom_site.pdbx_PDB_ins_code; for (var i = start + 1; i < end; i++) { var newChain = !label_entity_id.areValuesEqual(i - 1, i) || !label_asym_id.areValuesEqual(i - 1, i); var newResidue = newChain || !label_seq_id.areValuesEqual(i - 1, i) || !auth_seq_id.areValuesEqual(i - 1, i) || !pdbx_PDB_ins_code.areValuesEqual(i - 1, i); // not checking label_comp_id to allow for MICROHETEROGENEITY if (newResidue) residues[residues.length] = i; if (newChain) chains[chains.length] = i; } return { residues: residues, chains: chains }; } function createHierarchyData(atom_site, sourceIndex, offsets) { var atoms = Table.ofColumns(AtomsSchema, { type_symbol: Column.ofArray({ array: Column.mapToArray(atom_site.type_symbol, ElementSymbol), schema: Column.Schema.Aliased(Column.Schema.str) }), label_atom_id: atom_site.label_atom_id, auth_atom_id: atom_site.auth_atom_id, label_alt_id: atom_site.label_alt_id, label_comp_id: atom_site.label_comp_id, auth_comp_id: atom_site.auth_comp_id, pdbx_formal_charge: atom_site.pdbx_formal_charge }); var residues = Table.view(atom_site, ResiduesSchema, offsets.residues); var chains = Table.view(atom_site, ChainsSchema, offsets.chains); if (!residues.label_seq_id.isDefined) { var seqIds = new Int32Array(residues.label_seq_id.rowCount); var residueOffsets = offsets.residues, chainOffsets = offsets.chains; var cI = 0; var seqId = 0; for (var i = 0, il = seqIds.length; i < il; ++i) { if (residueOffsets[i] >= chainOffsets[cI + 1]) { cI += 1; seqId = 0; } seqIds[i] = ++seqId; // start id on one } residues.label_seq_id = Column.ofIntArray(seqIds); } // Optimize the numeric columns Table.columnToArray(residues, 'label_seq_id', Int32Array); Table.columnToArray(residues, 'auth_seq_id', Int32Array); return { atoms: atoms, residues: residues, chains: chains, atomSourceIndex: sourceIndex }; } function getConformation(atom_site) { return { id: UUID.create22(), atomId: atom_site.id, occupancy: atom_site.occupancy.isDefined ? atom_site.occupancy : Column.ofConst(1, atom_site._rowCount, Column.Schema.float), B_iso_or_equiv: atom_site.B_iso_or_equiv, xyzDefined: atom_site.Cartn_x.isDefined && atom_site.Cartn_y.isDefined && atom_site.Cartn_z.isDefined, x: atom_site.Cartn_x.toArray({ array: Float32Array }), y: atom_site.Cartn_y.toArray({ array: Float32Array }), z: atom_site.Cartn_z.toArray({ array: Float32Array }), }; } function isHierarchyDataEqual(a, b) { return Table.areEqual(a.chains, b.chains) && Table.areEqual(a.residues, b.residues) && Table.areEqual(a.atoms, b.atoms); } function createChainOperatorMappingAndSubstituteNames(hierarchy, format) { var mapping = new Map(); if (!MmcifFormat.is(format)) return mapping; var entries = toDatabase(AtomSiteOperatorMappingSchema, format.data.frame).molstar_atom_site_operator_mapping; if (entries._rowCount === 0) return mapping; var labelMap = new Map(); var authMap = new Map(); for (var i = 0; i < entries._rowCount; i++) { var assembly = entries.assembly_operator_id.valueKind(i) === 0 /* Column.ValueKind.Present */ ? { id: entries.assembly_id.value(i), operList: [], operId: entries.assembly_operator_id.value(i) } : void 0; var operator = SymmetryOperator.create(entries.operator_name.value(i), Mat4.identity(), { assembly: assembly, spgrOp: entries.symmetry_operator_index.valueKind(i) === 0 /* Column.ValueKind.Present */ ? entries.symmetry_operator_index.value(i) : void 0, hkl: Vec3.ofArray(entries.symmetry_hkl.value(i)), ncsId: entries.ncs_id.value(i) }); var suffix = entries.suffix.value(i); var label = entries.label_asym_id.value(i); labelMap.set("".concat(label).concat(suffix), { name: label, operator: operator }); var auth = entries.auth_asym_id.value(i); authMap.set("".concat(auth).concat(suffix), auth); } var _a = hierarchy.chains, label_asym_id = _a.label_asym_id, auth_asym_id = _a.auth_asym_id; var mappedLabel = new Array(label_asym_id.rowCount); var mappedAuth = new Array(label_asym_id.rowCount); for (var i = 0; i < label_asym_id.rowCount; i++) { var label = label_asym_id.value(i), auth = auth_asym_id.value(i); if (!labelMap.has(label)) { mappedLabel[i] = label; mappedAuth[i] = auth; continue; } var _b = labelMap.get(label), name_1 = _b.name, operator = _b.operator; mapping.set(i, operator); mappedLabel[i] = name_1; mappedAuth[i] = authMap.get(auth) || auth; } hierarchy.chains.label_asym_id = Column.ofArray({ array: mappedLabel, valueKind: hierarchy.chains.label_asym_id.valueKind, schema: hierarchy.chains.label_asym_id.schema }); hierarchy.chains.auth_asym_id = Column.ofArray({ array: mappedAuth, valueKind: hierarchy.chains.auth_asym_id.valueKind, schema: hierarchy.chains.auth_asym_id.schema }); return mapping; } function getAtomicHierarchy(atom_site, sourceIndex, entities, chemicalComponentMap, format, previous) { var hierarchyOffsets = findHierarchyOffsets(atom_site); var hierarchyData = createHierarchyData(atom_site, sourceIndex, hierarchyOffsets); var chainOperatorMapping = createChainOperatorMappingAndSubstituteNames(hierarchyData, format); if (previous && isHierarchyDataEqual(previous.atomicHierarchy, hierarchyData)) { return { sameAsPrevious: true, hierarchy: previous.atomicHierarchy, chainOperatorMapping: chainOperatorMapping }; } var hierarchySegments = { residueAtomSegments: Segmentation.ofOffsets(hierarchyOffsets.residues, Interval.ofBounds(0, atom_site._rowCount)), chainAtomSegments: Segmentation.ofOffsets(hierarchyOffsets.chains, Interval.ofBounds(0, atom_site._rowCount)), }; var index = getAtomicIndex(hierarchyData, entities, hierarchySegments); var derived = getAtomicDerivedData(hierarchyData, hierarchySegments, index, chemicalComponentMap); var hierarchy = __assign(__assign(__assign({}, hierarchyData), hierarchySegments), { index: index, derived: derived }); return { sameAsPrevious: false, hierarchy: hierarchy, chainOperatorMapping: chainOperatorMapping }; } export function getAtomicHierarchyAndConformation(atom_site, sourceIndex, entities, chemicalComponentMap, format, previous) { var _a = getAtomicHierarchy(atom_site, sourceIndex, entities, chemicalComponentMap, format, previous), sameAsPrevious = _a.sameAsPrevious, hierarchy = _a.hierarchy, chainOperatorMapping = _a.chainOperatorMapping; var conformation = getConformation(atom_site); return { sameAsPrevious: sameAsPrevious, hierarchy: hierarchy, conformation: conformation, chainOperatorMapping: chainOperatorMapping }; }