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assemblies,bandFileName,bandDataFileNames={9606:"",10090:""};for(i=0;i<taxids.length;i++)taxid=String(taxids[i]),ideo.config.assembly||(ideo.config.assembly="default"),assemblies=ideo.organisms[taxid].assemblies,accession=ideo.assemblyIsAccession()?ideo.config.assembly:assemblies[ideo.config.assembly],bandFileName=[],bandFileName.push(Ideogram.slugify(ideo.organisms[taxid].scientificName)),accession!==assemblies.default&&bandFileName.push(accession),"9606"===taxid&&(accession in assemblies==="false"&&-1===Object.values(assemblies).indexOf(ideo.config.assembly)||""!==resolution&&850!==resolution)&&bandFileName.push(resolution),bandFileName=bandFileName.join("-")+".js","9606"!==taxid&&"10090"!==taxid||(bandDataFileNames[taxid]=bandFileName),void 0!==accession&&!1===/GCA_/.test(ideo.config.assembly)&&"undefined"==typeof chrBands&&taxid in bandDataFileNames?d3.request(ideo.config.dataDir+bandDataFileNames[taxid]).on("beforesend",function(t){t.taxid=taxid}).get(function(error,data){eval(data.response),ideo.bandData[data.taxid]=chrBands,(numBandDataResponses+=1)===taxids.length&&(bandsArray=ideo.processBandData(),writeContainer())}):("undefined"!=typeof chrBands&&(ideo.bandData[taxid]=chrBands),bandsArray=ideo.processBandData(),writeContainer())})}__webpack_require__.d(__webpack_exports__,"a",function(){return configure}),__webpack_require__.d(__webpack_exports__,"c",function(){return initDrawChromosomes}),__webpack_require__.d(__webpack_exports__,"d",function(){return onLoad}),__webpack_require__.d(__webpack_exports__,"b",function(){return init});var __WEBPACK_IMPORTED_MODULE_0_d3_request__=__webpack_require__(16),__WEBPACK_IMPORTED_MODULE_1_d3_selection__=__webpack_require__(0),__WEBPACK_IMPORTED_MODULE_2_es6_promise__=__webpack_require__(89),__WEBPACK_IMPORTED_MODULE_2_es6_promise___default=__webpack_require__.n(__WEBPACK_IMPORTED_MODULE_2_es6_promise__),__WEBPACK_IMPORTED_MODULE_3__ploidy__=__webpack_require__(90),__WEBPACK_IMPORTED_MODULE_4__layouts_layout__=__webpack_require__(250),d3=Object.assign({},__WEBPACK_IMPORTED_MODULE_0_d3_request__,__WEBPACK_IMPORTED_MODULE_1_d3_selection__)},function(t,e){function n(){throw new Error("setTimeout has not been defined")}function r(){throw new Error("clearTimeout has not been defined")}function i(t){if(f===setTimeout)return setTimeout(t,0);if((f===n||!f)&&setTimeout)return f=setTimeout,setTimeout(t,0);try{return f(t,0)}catch(e){try{return f.call(null,t,0)}catch(e){return f.call(this,t,0)}}}function o(t){if(l===clearTimeout)return clearTimeout(t);if((l===r||!l)&&clearTimeout)return l=clearTimeout,clearTimeout(t);try{return l(t)}catch(e){try{return l.call(null,t)}catch(e){return l.call(this,t)}}}function a(){g&&d&&(g=!1,d.length?p=d.concat(p):m=-1,p.length&&s())}function s(){if(!g){var t=i(a);g=!0;for(var e=p.length;e;){for(d=p,p=[];++m<e;)d&&d[m].run();m=-1,e=p.length}d=null,g=!1,o(t)}}function c(t,e){this.fun=t,this.array=e}function u(){}var f,l,h=t.exports={};!function(){try{f="function"==typeof setTimeout?setTimeout:n}catch(t){f=n}try{l="function"==typeof clearTimeout?clearTimeout:r}catch(t){l=r}}();var d,p=[],g=!1,m=-1;h.nextTick=function(t){var e=new Array(arguments.length-1);if(arguments.length>1)for(var n=1;n<arguments.length;n++)e[n-1]=arguments[n];p.push(new c(t,e)),1!==p.length||g||i(s)},c.prototype.run=function(){this.fun.apply(null,this.array)},h.title="browser",h.browser=!0,h.env={},h.argv=[],h.version="",h.versions={},h.on=u,h.addListener=u,h.once=u,h.off=u,h.removeListener=u,h.removeAllListeners=u,h.emit=u,h.prependListener=u,h.prependOnceListener=u,h.listeners=function(t){return[]},h.binding=function(t){throw new Error("process.binding is not supported")},h.cwd=function(){return"/"},h.chdir=function(t){throw new Error("process.chdir is not supported")},h.umask=function(){return 0}},function(t,e){var n;n=function(){return this}();try{n=n||Function("return this")()||(0,eval)("this")}catch(t){"object"==typeof window&&(n=window)}t.exports=n},function(t,e){},function(t,e,n){"use strict";function r(t,e){if(!t)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return!e||"object"!=typeof e&&"function"!=typeof e?t:e}function i(t,e){if("function"!=typeof e&&null!==e)throw new TypeError("Super expression must either be null or a function, not "+typeof e);t.prototype=Object.create(e&&e.prototype,{constructor:{value:t,enumerable:!1,writable:!0,configurable:!0}}),e&&(Object.setPrototypeOf?Object.setPrototypeOf(t,e):t.__proto__=e)}function o(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}n.d(e,"a",function(){return f});var a=n(0),s=n(251),c=function(){function t(t,e){for(var n=0;n<e.length;n++){var r=e[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),u=Object.assign({},a),f=function(){function t(e,n){if(o(this,t),this._config=e,this._ideo=n,this._ploidy=this._ideo._ploidy,this._translate=void 0,"chrSetMargin"in e)this.chrSetMargin=e.chrSetMargin;else{var r=this._config.chrMargin;this.chrSetMargin=this._config.ploidy>1?r:0}this._tickSize=8,this._isRotated=!1}return c(t,[{key:"_getLeftMargin",value:function(){return this._margin.left}},{key:"_getYScale",value:function(){return 20/this._config.chrWidth}},{key:"getChromosomeLabels",value:function(t){var e=new s.a(t);return[e.getSetLabel(),e.getLabel()].filter(function(t){return t.length>0})}},{key:"rotateBack",value:function(){throw new Error(this._class+"#rotateBack not implemented")}},{key:"rotateForward",value:function(){throw new Error(this._class+"#rotateForward not implemented")}},{key:"rotate",value:function(t,e,n){var r=this._ideo,i=u.selectAll(r.selector+" g.chromosome").filter(function(){return this!==n});this._isRotated?(this._isRotated=!1,this.rotateBack(t,e,n,function(){i.style("display",null),u.selectAll(r.selector+" .chrSetLabel, .chrLabel").style("display",null)})):(this._isRotated=!0,i.style("display","none"),u.selectAll(r.selector+" .chrSetLabel, .chrLabel").style("display","none"),this.rotateForward(t,e,n))}},{key:"getChromosomeLabelClass",value:function(){return 1===this._config.ploidy?"chrLabel":"chrSetLabel"}},{key:"_getAdditionalOffset",value:function(){return(this._config.annotationHeight||0)*(this._config.numAnnotTracks||1)}},{key:"_getChromosomeSetSize",value:function(t){return this._ploidy.getSetSize(t)*this._config.chrWidth*2+this.chrSetMargin}},{key:"getMargin",value:function(){return this._margin}},{key:"getChromosomeSetLabelAnchor",value:function(){return"middle"}},{key:"getChromosomeLabelYPosition",value:function(){return-5.5}},{key:"getChromosomeSetLabelYPosition",value:function(t){return 1===this._config.ploidy?this.getChromosomeLabelYPosition(t):-2*this._config.chrWidth}}],[{key:"getInstance",value:function(t,e){return"perspective"in t&&"comparative"===t.perspective?new h(t,e):"rows"in t&&t.rows>1?new d(t,e):"vertical"===t.orientation?new p(t,e):"horizontal"===t.orientation?new l(t,e):new p(t,e)}}]),t}(),l=function(t){function e(t,n){o(this,e);var i=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t,n));return i._class="HorizontalLayout",i._margin={left:20,top:30},i}return i(e,t),c(e,[{key:"_getLeftMargin",value:function(){var t=f.prototype._getLeftMargin.call(this);return this._config.ploidy>1&&(t*=1.8),t}},{key:"rotateForward",value:function(t,e,n,r){var i=u.select(this._ideo.selector).node().getBoundingClientRect(),o=n.getBoundingClientRect(),a=i.height/(o.width+15)*.9,s=this._getYScale(),c=(e+1)*(2*this._config.chrWidth*s),f="rotate(90) translate(30, -"+c+") scale("+a+", "+s+")";u.select(n.parentNode).transition().attr("transform",f).on("end",r);var l=this.getChromosomeLabels(n);u.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(l).enter().append("text").attr("class",function(t,e){return 0===e&&2===l.length?"chrSetLabel":null}).attr("x",30).attr("y",function(t,e){return 12*(e+1+l.length%2)}).style("text-anchor","middle").style("opacity",0).text(String).transition().style("opacity",1)}},{key:"rotateBack",value:function(t,e,n,r){var i=this.getChromosomeSetTranslate(t);u.select(n.parentNode).transition().attr("transform",i).on("end",r),u.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove()}},{key:"getHeight",value:function(t){var e=this._config.chromosomes[t].length,n=this.getChromosomeSetYTranslate(e-1);return(n+=this._getChromosomeSetSize(e-1))+2*this._getAdditionalOffset()}},{key:"getWidth",value:function(){return this._config.chrHeight+1.5*this._margin.top}},{key:"getChromosomeSetLabelAnchor",value:function(){return"end"}},{key:"getChromosomeBandLabelAnchor",value:function(){return null}},{key:"getChromosomeBandTickY1",value:function(){return 2}},{key:"getChromosomeBandTickY2",value:function(){return 10}},{key:"getChromosomeBandLabelTranslate",value:function(t){var e=this._ideo.round(-this._tickSize+t.px.start+t.px.width/2);return{x:e,y:-10,translate:"translate("+e+","+-10+")"}}},{key:"getChromosomeSetLabelTranslate",value:function(){return null}},{key:"getChromosomeSetTranslate",value:function(t){return"translate("+this._getLeftMargin()+", "+this.getChromosomeSetYTranslate(t)+")"}},{key:"getChromosomeSetYTranslate",value:function(t){if(!this._config.ploidyDesc)return this._config.chrMargin*(t+1);if(!this._translate){this._translate=[1];for(var e=1;e<this._config.ploidyDesc.length;e++)this._translate[e]=this._translate[e-1]+this._getChromosomeSetSize(e-1)}return this._translate[t]}},{key:"getChromosomeSetLabelXPosition",value:function(t){return 1===this._config.ploidy?this.getChromosomeLabelXPosition(t):-20}},{key:"getChromosomeSetLabelYPosition",value:function(t){var e=this._ploidy.getSetSize(t),n=this._config,r=n.chrMargin,i=n.chrWidth;return 1===n.ploidy?i/2+3:e*r/2}},{key:"getChromosomeLabelXPosition",value:function(){return-8}},{key:"getChromosomeLabelYPosition",value:function(){return this._config.chrWidth}}]),e}(f),h=function(t){function e(t,n){o(this,e);var i=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t,n));return i._class="PairedLayout",i._margin={left:30},i}return i(e,t),c(e,[{key:"rotateForward",value:function(t,e,n,r){var i=this,o=this._ideo,a=u.select(o.selector).node().getBoundingClientRect(),s=n.getBoundingClientRect(),c=a.width/s.height*.97,f=this._getYScale(),l=t?150:25,h="translate(15, "+l+") scale("+c+", "+f+")";u.select(n.parentNode).transition().attr("transform",h).on("end",function(){r&&r();var e=6*Number(!t);u.select(n.parentNode).selectAll("g.bandLabel text").attr("transform","rotate(90) translate(0, "+e+")").attr("text-anchor","middle"),u.selectAll(o.selector+" .syntenicRegion").style("display","none")});var d=this.getChromosomeLabels(n);u.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(this.getChromosomeLabels(n)).enter().append("text").attr("class",function(t,e){return 0===e&&2===d.length?"chrSetLabel":null}).attr("x",0).attr("y",l+i._config.chrWidth*c/2*1.15).style("opacity",0).text(String).transition().style("opacity",1)}},{key:"rotateBack",value:function(t,e,n,r){var i=this._ideo,o=this.getChromosomeSetTranslate(t);u.select(n.parentNode).transition().attr("transform",o).on("end",function(){r(),u.selectAll(i.select+" .syntenicRegion").style("display",null),u.select(n.parentNode).selectAll("g.bandLabel text").attr("transform",null).attr("text-anchor",t?null:"end")}),u.selectAll(i.selector+" g.tmp").style("opacity",0).remove()}},{key:"getHeight",value:function(){return this._config.chrHeight+1.5*this._margin.left}},{key:"getWidth",value:function(){return"97%"}},{key:"getChromosomeBandTickY1",value:function(t){return t%2?this._config.chrWidth:2*this._config.chrWidth}},{key:"getChromosomeBandTickY2",value:function(t){var e=this._config.chrWidth;return t%2?e-this._tickSize:2*e+this._tickSize}},{key:"getChromosomeBandLabelAnchor",value:function(t){return t%2?null:"end"}},{key:"getChromosomeBandLabelTranslate",value:function(t,e){var n=e%2?10:-this._config.chrWidth-10,r=this._ideo.round(t.px.start+t.px.width/2)+3;return{x:r,y:r,translate:"rotate(-90) translate("+n+", "+r+")"}}},{key:"getChromosomeLabelXPosition",value:function(){return-this._tickSize}},{key:"getChromosomeSetLabelXPosition",value:function(){return this._config.chrWidth/-2}},{key:"getChromosomeSetLabelTranslate",value:function(){return"rotate(-90)"}},{key:"getChromosomeSetTranslate",value:function(t){var e=this.getChromosomeSetYTranslate(t);return"rotate(90) translate("+this._margin.left+", -"+e+")"}},{key:"getChromosomeSetYTranslate",value:function(t){return 200*(t+1)}}]),e}(f),d=function(t){function e(t,n){o(this,e);var i=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t,n));return i._class="SmallLayout",i._margin={left:36.5,top:10},i}return i(e,t),c(e,[{key:"getHeight",value:function(){var t=this._config.chrHeight;return this._config.rows*(t+1.5*this._margin.top)}},{key:"getWidth",value:function(){return"97%"}},{key:"getChromosomeBandLabelTranslate",value:function(){}},{key:"getChromosomeSetLabelTranslate",value:function(){return"rotate(-90)"}},{key:"getChromosomeSetTranslate",value:function(t){var e=[];this._ideo.getTaxids(function(t){e=t});var n,r,i=this._ideo.config.chromosomes[e[0]].length,o=i/this._config.rows;return t>o-1?(n=this._margin.left+1.4*this._config.chrHeight,r=this.getChromosomeSetYTranslate(t-o)):(n=this._margin.left,r=this.getChromosomeSetYTranslate(t)),"rotate(90) translate("+n+", -"+r+")"}},{key:"getChromosomeSetYTranslate",value:function(t){var e=this._getAdditionalOffset();return this._margin.left*t+this._config.chrWidth+2*e+e*t}},{key:"getChromosomeSetLabelXPosition",value:function(t){return(this._ploidy.getSetSize(t)*this._config.chrWidth+20)/-2+(this._config.ploidy>1?0:this._config.chrWidth)}},{key:"getChromosomeLabelXPosition",value:function(){return this._config.chrWidth/-2}}]),e}(f),p=function(t){function e(t,n){o(this,e);var i=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t,n));return i._class="VerticalLayout",i._margin={top:30,left:15},i}return i(e,t),c(e,[{key:"rotateForward",value:function(t,e,n,r){var i=this,o=u.select(this._ideo.selector).node().getBoundingClientRect(),a=n.getBoundingClientRect(),s=o.width/a.height*.97,c=this._getYScale(),f="translate(20, 25) scale("+s+", "+c+")";u.select(n.parentNode).transition().attr("transform",f).on("end",r);var l=this.getChromosomeLabels(n),h=1.3*(20+i._config.chrWidth);u.select(this._ideo.getSvg()).append("g").attr("class","tmp").selectAll("text").data(l).enter().append("text").attr("class",function(t,e){return 0===e&&2===l.length?"chrSetLabel":null}).attr("x",0).attr("y",h).style("opacity",0).text(String).transition().style("opacity",1)}},{key:"rotateBack",value:function(t,e,n,r){var i=this.getChromosomeSetTranslate(t);u.select(n.parentNode).transition().attr("transform",i).on("end",r),u.selectAll(this._ideo.selector+" g.tmp").style("opacity",0).remove()}},{key:"getHeight",value:function(){return this._config.chrHeight+1.5*this._margin.top}},{key:"getWidth",value:function(){return"97%"}},{key:"getChromosomeBandLabelTranslate",value:function(){}},{key:"getChromosomeSetLabelTranslate",value:function(){return"rotate(-90)"}},{key:"getChromosomeSetTranslate",value:function(t){return"rotate(90) translate("+this._margin.top+", -"+this.getChromosomeSetYTranslate(t)+")"}},{key:"getChromosomeSetYTranslate",value:function(t){var e,n=this._getAdditionalOffset(),r=this._config.chrMargin,i=this._config.chrWidth;if(!this._config.ploidyDesc)return"histogram"===this._config.annotationsLayout?r/2+t*(r+i+2)+2*n+1:(e=i+t*(r+i)+2*n,n>0?e:e+4+2*t);if(!this._translate){this._translate=[this._ploidy.getSetSize(0)*i*2];for(var o,a=1;a<this._config.ploidyDesc.length;a++)o=this._translate[a-1],this._translate[a]=o+this._getChromosomeSetSize(a-1)}return this._translate[t]}},{key:"getChromosomeSetLabelXPosition",value:function(){return this._config.chrWidth*this._config.ploidy/-2}},{key:"getChromosomeLabelXPosition",value:function(){return this._config.chrWidth/-2}}]),e}(f)},function(t,e,n){"use strict";function r(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}n.d(e,"a",function(){return s});var i=n(0),o=function(){function t(t,e){for(var n=0;n<e.length;n++){var r=e[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),a=Object.assign({},i),s=function(){function t(e){r(this,t),this._node=e}return o(t,[{key:"getLabel",value:function(){return a.select(this._node).select("text.chrLabel").text()}},{key:"getSetLabel",value:function(){return a.select(this._node.parentNode).select("text.chromosome-set-label").text()}}]),t}()},function(t,e,n){"use strict";function r(){call(this.onDrawAnnotsCallback)}function i(t){var e,n,r,i,o,a,s,c,u,f,l,h,d,p,g,m=this;for(e=t.keys,t=t.annots,s=[],o=-1,n=0;n<t.length;n++)if(c=t[n],u=c.chr,void 0!==(f=m.chromosomes[m.config.taxid][u]))for(o++,s.push({chr:c.chr,annots:[]}),r=0;r<c.annots.length;r++){for(l=c.annots[r],a={},i=0;i<e.length;i++)a[e[i]]=l[i];a.stop=a.start+a.length,h=m.convertBpToPx(f,a.start),d=m.convertBpToPx(f,a.stop),p=Math.round((h+d)/2)-28,g=m.config.annotationsColor,m.config.annotationTracks?(a.trackIndex=l[3],g=m.config.annotationTracks[a.trackIndex].color):a.trackIndex=0,"color"in a&&(g=a.color),a.chr=u,a.chrIndex=n,a.px=p,a.startPx=h-30,a.stopPx=d-30,a.color=g,s[o].annots.push(a)}else console.warn('Chromosome "'+u+'" undefined in ideogram; '+c.annots.length+" annotations not shown");return s}function o(){if(this.config.annotationsPath||this.config.localAnnotationsPath||this.annots||this.config.annotations){if(!this.config.annotationHeight){var t=Math.round(this.config.chrHeight/100);this.config.annotationHeight=t}this.config.annotationTracks?this.config.numAnnotTracks=this.config.annotationTracks.length:this.config.numAnnotTracks=1,this.config.annotTracksHeight=this.config.annotationHeight*this.config.numAnnotTracks,void 0===this.config.barWidth&&(this.config.barWidth=3)}else this.config.annotTracksHeight=0;void 0===this.config.annotationsColor&&(this.config.annotationsColor="#F00")}function a(t){var e=this;if("http"!==t.slice(0,4))return void b.json(e.config.annotationsPath,function(t){e.rawAnnots=t});var n=t.split("."),r=n[n.length-1];if("bed"!==r&&"json"!==r)return r=r.toUpperCase(),void alert("This Ideogram.js only supports BED and native format at the moment.  Sorry, check back soon for "+r+" support!");b.request(t,function(t){e.rawAnnots="bed"===r?new m.a(t.response,e).rawAnnots:JSON.parse(t.response)})}function s(t){var e,n,r,i,o,a,s=this,c=[],u=s.chromosomes[s.config.taxid];if("annots"in t[0])return s.drawProcessedAnnots(t);for(a in u)c.push({chr:a,annots:[]});for(e=0;e<t.length;e++)for(r=t[e],n=0;n<c.length;n++)if(r.chr===c[n].chr){i=[r.name,r.start,r.stop-r.start],"color"in r&&i.push(r.color),"shape"in r&&i.push(r.shape),c[n].annots.push(i);break}o=["name","start","length"],"color"in t[0]&&o.push("color"),"shape"in t[0]&&o.push("shape"),s.rawAnnots={keys:o,annots:c},s.annots=s.processAnnotData(s.rawAnnots),s.drawProcessedAnnots(s.annots)}function c(t){var e,n,r,i,o,a,s,c,u,f,l,h,d,p,g,m,b,_,v,y,w,x,O,M,C,k=(new Date).getTime(),A=!1,j=this;d=[],b=j.config.barWidth,o=j.chromosomes[j.config.taxid],v=j.config.annotationsColor,C="histogramScaling"in j.config?j.config.histogramScaling:"relative",void 0===j.maxAnnotsPerBar&&(j.maxAnnotsPerBar={},A=!0);for(r in o){for(i=o[r],l=i.chrIndex,y=i.bands[i.bands.length-1],a=y.px.stop,w=Math.round(a/b),p={chr:r,annots:[]},e=0;e<w;e++)s=e*b-j.bump,c=j.convertPxToBp(i,s+j.bump),p.annots.push({bp:c,px:s-j.bump,count:0,chrIndex:l,chrName:r,color:v,annots:[]});d.push(p)}for(r in t)for(u=t[r].annots,f=t[r].chr,i=o[f],l=i.chrIndex-1,x=d[l].annots,e=0;e<u.length;e++)for(h=u[e],s=h.px-j.bump,n=0;n<x.length;n++)if(g=x[n].px,m=g+b,n===x.length-1&&(m+=b),s>=g&&s<m){d[l].annots[n].count+=1,d[l].annots[n].annots.push(h);break}if(!0===A||"relative"===C){for(_=0,e=0;e<d.length;e++)for(t=d[e].annots,n=0;n<t.length;n++)(O=t[n].count)>_&&(_=O);j.maxAnnotsPerBar[r]=_}for(e=0;e<d.length;e++)for(t=d[e].annots,n=0;n<t.length;n++)O=t[n].count,M=O/j.maxAnnotsPerBar[r]*j.config.chrMargin,d[e].annots[n].height=M;var T=(new Date).getTime();return j.config.debug&&console.log("Time spent in getHistogramBars: "+(T-k)+" ms"),j.bars=d,d}function u(t){var e,n,r,i,o,a,s;for(e=[],n=[],r=this.chromosomesArray,i=0;i<r.length;i++)o=r[i].name,n.push(o),e.push({chr:o,annots:[]});for(i=0;i<t.length;i++)a=t[i],-1!==(s=n.indexOf(a.chr))&&(e[s]=a);return e}function f(t){var e,n,r,i,o,a,s,c,u,f,l,h,d=this;e=this.config.chrWidth,n="tracks",this.config.annotationsLayout&&(n=this.config.annotationsLayout),"histogram"===n&&(t=d.getHistogramBars(t)),r=d.config.annotationHeight,i="l -"+r+" "+2*r+" l "+2*r+" 0 z",a=r,o="m -"+a+", "+a+"a "+a+","+a+" 0 1,0 "+2*a+",0a "+a+","+a+" 0 1,0 -"+2*a+",0",h=d.fillAnnots(t),s=b.selectAll(d.selector+" .chromosome").data(h).selectAll("path.annot").data(function(t){return t.annots}).enter(),"tracks"===n?s.append("g").attr("id",function(t){return t.id}).attr("class","annot").attr("transform",function(t){var e=d.config.chrWidth+t.trackIndex*r*2;return"translate("+t.px+","+e+")"}).append("path").attr("d",function(t){return t.shape&&"triangle"!==t.shape?"circle"===t.shape?o:void 0:"m0,0"+i}).attr("fill",function(t){return t.color}):"overlay"===n?s.append("polygon").attr("id",function(t){return t.id}).attr("class","annot").attr("points",function(t){return t.stopPx-t.startPx>1?(c=t.startPx,u=t.stopPx):(c=t.px-.5,u=t.px+.5),f=e,l=0,c+","+f+" "+u+","+f+" "+u+","+l+" "+c+","+l}).attr("fill",function(t){return t.color}):"histogram"===n&&s.append("polygon").attr("class","annot").attr("points",function(t){c=t.px+d.bump,u=t.px+d.config.barWidth+d.bump,f=e,l=e+t.height;var n=d.chromosomesArray[t.chrIndex-1].width;return u>n&&(u=n),c+","+f+" "+u+","+f+" "+u+","+l+" "+c+","+l}).attr("fill",function(t){return t.color}),d.onDrawAnnotsCallback&&d.onDrawAnnotsCallback()}function l(t){var e,n,r,i,o,a,s,c,u,f=(new Date).getTime(),l=this;for(r=b.select(l.selector).insert("g",":first-child").attr("class","synteny"),i=0;i<t.length;i++){c=t[i],e=c.r1,n=c.r2,o="#CFC","color"in c&&(o=c.color),a=1,"opacity"in c&&(a=c.opacity),e.startPx=this.convertBpToPx(e.chr,e.start),e.stopPx=this.convertBpToPx(e.chr,e.stop),n.startPx=this.convertBpToPx(n.chr,n.start),n.stopPx=this.convertBpToPx(n.chr,n.stop),s=e.chr.id+"_"+e.start+"_"+e.stop+"___"+n.chr.id+"_"+n.start+"_"+n.stop,u=r.append("g").attr("class","syntenicRegion").attr("id",s).on("click",function(){var t=this,e=b.selectAll(l.selector+" .syntenicRegion").filter(function(){return this!==t});e.classed("hidden",!e.classed("hidden"))}).on("mouseover",function(){var t=this;b.selectAll(l.selector+" .syntenicRegion").filter(function(){return this!==t}).classed("ghost",!0)}).on("mouseout",function(){b.selectAll(l.selector+" .syntenicRegion").classed("ghost",!1)});var h=l.config.chrWidth,d=this._layout.getChromosomeSetYTranslate(0),p=this._layout.getChromosomeSetYTranslate(1)-h;u.append("polygon").attr("points",d+", "+e.startPx+" "+d+", "+e.stopPx+" "+p+", "+n.stopPx+" "+p+", "+n.startPx).attr("style","fill: "+o+"; fill-opacity: 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r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),o=function(){function t(e,n){r(this,t),this.rawAnnots=this.parseBed(e,n)}return i(t,[{key:"parseBed",value:function(e,n){var r,i,o,a,s,c,u,f,l,h,d,p,g,m,b,_;for(l=[],a=Object.keys(n.chromosomes[n.config.taxid]),i=0;i<a.length;i++)s=a[i],l.push({chr:s,annots:[]});for(r=e.split(/\r\n|\n/),d=0,p=!0,("chr"===r[0].slice(0,3)||isNaN(parseInt(r[0],10)))&&(d=1),!1===isNaN(parseInt(r[d],10))&&(p=!1),i=d;i<r.length;i++)o=r[i].split(/\s/g),s=o[0],c=parseInt(o[1],10),u=parseInt(o[2],10),length=u-c,p&&(s=s.slice(3)),-1!==(f=a.indexOf(s))&&(h=["",c,length,0],o.length>=4&&(b=o[3],h[0]=b),o.length>=8&&(g=o[8].split(","),m=t.rgbToHex(g[0],g[1],g[2]),h.push(m)),l[f].annots.push(h));return _=["name","start","length","trackIndex"],r[d].length>=8&&_.push("color"),{keys:_,annots:l}}}],[{key:"componentToHex",value:function(t){var e=parseInt(t,10).toString(16);return 1===e.length?"0"+e:e}},{key:"rgbToHex",value:function(e,n,r){return"#"+t.componentToHex(e)+t.componentToHex(n)+t.componentToHex(r)}}]),t}()},function(module,__webpack_exports__,__webpack_require__){"use strict";function getTaxidFromEutils(t){var e,n,r,i=this;e=i.config.organism,n=i.esearch+"&db=taxonomy&term="+e,d3.json(n,function(e){return r=e.esearchresult.idlist[0],t(r)})}function getOrganismFromEutils(t){var e,n,r,i=this;r=i.config.organism,n=i.esummary+"&db=taxonomy&id="+r,d3.json(n,function(n){return e=n.result[String(r)].commonname,i.config.organism=e,t(e)})}function getTaxids(callback){var ideo=this,taxid,taxids,org,orgs,i,taxidInit,tmpChrs,assembly,chromosomes,multiorganism,promise;if(taxidInit="taxid"in ideo.config,ideo.config.multiorganism="organism"in ideo.config&&ideo.config.organism instanceof Array||taxidInit&&ideo.config.taxid instanceof Array,multiorganism=ideo.config.multiorganism,"organism"in ideo.config){for(orgs=multiorganism?ideo.config.organism:[ideo.config.organism],taxids=[],tmpChrs={},i=0;i<orgs.length;i++){org=orgs[i];for(taxid in ideo.organisms)ideo.organisms[taxid].commonName.toLowerCase()===org&&(taxids.push(taxid),multiorganism&&(tmpChrs[taxid]=ideo.config.chromosomes[org]))}0===taxids.length||ideo.assemblyIsAccession()&&/GCA_/.test(ideo.config.assembly)?(promise=new __WEBPACK_IMPORTED_MODULE_3_es6_promise__.Promise(function(t){ideo.getTaxidFromEutils(t)}),promise.then(function(data){var organism=ideo.config.organism,dataDir=ideo.config.dataDir,urlOrg=organism.replace(" ","-");taxid=data,-1===taxids.indexOf(taxid)&&taxids.push(taxid),ideo.config.taxids=taxids,ideo.organisms[taxid]={commonName:"",scientificName:ideo.config.organism,scientificNameAbbr:""};var fullyBandedTaxids=["9606","10090","10116"];-1!==fullyBandedTaxids.indexOf(taxid)&&!1===ideo.config.showFullyBanded&&(urlOrg+="-no-bands");var chromosomesUrl=dataDir+urlOrg+".js",promise=new __WEBPACK_IMPORTED_MODULE_3_es6_promise__.Promise(function(t,e){d3.request(chromosomesUrl).get(function(n,r){n&&e(Error(n)),t(r)})});return promise.then(function(data){var asmAndChrArray=[],chromosomes=[],seenChrs={},chr;eval(data.response),asmAndChrArray.push("");for(var i=0;i<chrBands.length;i++)(chr=chrBands[i].split(" ")[0])in seenChrs||(chromosomes.push({name:chr,type:"nuclear"}),seenChrs[chr]=1);return chromosomes=chromosomes.sort(Ideogram.sortChromosomes),asmAndChrArray.push(chromosomes),ideo.coordinateSystem="iscn",asmAndChrArray},function(){return new __WEBPACK_IMPORTED_MODULE_3_es6_promise__.Promise(function(t){ideo.coordinateSystem="bp",ideo.getAssemblyAndChromosomesFromEutils(t)})})}).then(function(t){assembly=t[0],chromosomes=t[1],ideo.config.chromosomes=chromosomes,ideo.organisms[taxid].assemblies={default:assembly},callback(taxids)})):(ideo.config.taxids=taxids,multiorganism&&(ideo.config.chromosomes=tmpChrs),callback(taxids))}else multiorganism?(ideo.coordinateSystem="bp",taxidInit&&(taxids=ideo.config.taxid)):(taxidInit&&(taxids=[ideo.config.taxid]),ideo.config.taxids=taxids),callback(taxids)}function getAssemblyAndChromosomesFromEutils(t){var e,n,r,i,o,a,s,c,u,f,l,h,d,p,g,m,b,_,v,y=this;n=y.config.organism,e=[],i=[],o=y.assemblyIsAccession()?y.config.assembly+"%22[Assembly%20Accession]":n+"%22[organism]AND%20(%22latest%20refseq%22[filter])%20",a=y.esearch+"&db=assembly&term=%22"+o+"AND%20(%22chromosome%20level%22[filter]%20OR%20%22complete%20genome%22[filter])",d3.promise.json(a).then(function(t){return s=t.esearchresult.idlist[0],c=y.esummary+"&db=assembly&id="+s,d3.promise.json(c)}).then(function(t){u=t.result[s].gbuid,r=t.result[s].assemblyaccession,e.push(r);var n="&db=nuccore&linkname=gencoll_nuccore_chr&from_uid="+u;return f=y.elink+n,d3.promise.json(f)}).then(function(t){return l=t.linksets[0].linksetdbs[0].links.join(","),h=y.esummary+"&db=nucleotide&id="+l,d3.promise.json(h)}).then(function(n){d=n.result;for(var r in d)if(p=d[r],"uids"!==r){if("mitochondrion"===p.genome){if(!y.config.showNonNuclearChromosomes)continue;v=p.genome,g=p.subtype.split("|").indexOf("plasmid"),m=-1===g?"MT":p.subname.split("|")[g]}else if("chloroplast"===p.genome||"plastid"===p.genome){if(v="chloroplast",!y.config.showNonNuclearChromosomes)continue;m="CP"}else v="nuclear",g=p.subtype.split("|").indexOf("chromosome"),void 0!==(m=p.subname.split("|")[g])&&"chr"===m.substr(0,3)&&(m=m.substr(3));b=p.slen,_={name:m,length:b,type:v},i.push(_)}return i=i.sort(Ideogram.sortChromosomes),e.push(i),y.coordinateSystem="bp",t(e)})}__webpack_require__.d(__webpack_exports__,"d",function(){return eutils}),__webpack_require__.d(__webpack_exports__,"b",function(){return esearch}),__webpack_require__.d(__webpack_exports__,"c",function(){return esummary}),__webpack_require__.d(__webpack_exports__,"a",function(){return elink}),__webpack_require__.d(__webpack_exports__,"g",function(){return getTaxidFromEutils}),__webpack_require__.d(__webpack_exports__,"f",function(){return getOrganismFromEutils}),__webpack_require__.d(__webpack_exports__,"h",function(){return getTaxids}),__webpack_require__.d(__webpack_exports__,"e",function(){return getAssemblyAndChromosomesFromEutils});var __WEBPACK_IMPORTED_MODULE_0_d3_request__=__webpack_require__(16),__WEBPACK_IMPORTED_MODULE_1_d3_dispatch__=__webpack_require__(8),__WEBPACK_IMPORTED_MODULE_2_d3_promise__=__webpack_require__(43),__WEBPACK_IMPORTED_MODULE_2_d3_promise___default=__webpack_require__.n(__WEBPACK_IMPORTED_MODULE_2_d3_promise__),__WEBPACK_IMPORTED_MODULE_3_es6_promise__=__webpack_require__(89),__WEBPACK_IMPORTED_MODULE_3_es6_promise___default=__webpack_require__.n(__WEBPACK_IMPORTED_MODULE_3_es6_promise__),d3=Object.assign({},__WEBPACK_IMPORTED_MODULE_0_d3_request__,__WEBPACK_IMPORTED_MODULE_1_d3_dispatch__);d3.promise=__WEBPACK_IMPORTED_MODULE_2_d3_promise__;var eutils="https://eutils.ncbi.nlm.nih.gov/entrez/eutils/",esearch=eutils+"esearch.fcgi?retmode=json",esummary=eutils+"esummary.fcgi?retmode=json",elink=eutils+"elink.fcgi?retmode=json"},function(module,__webpack_exports__,__webpack_require__){"use strict";function getBands(content,taxid,chromosomes){var lines={},delimiter,tsvLines,columns,line,stain,chr,i,init,tsvLinesLength,source,start,stop,firstColumn,tmp;if("window.chrBands"===content.slice(0,15)&&(source="native"),chromosomes instanceof Array&&"object"===_typeof(chromosomes[0])){for(tmp=[],i=0;i<chromosomes.length;i++)tmp.push(chromosomes[i].name);chromosomes=tmp}if("undefined"==typeof chrBands&&"native"!==source?(delimiter=/\t/,tsvLines=content.split(/\r\n|\n/),init=1):(delimiter=/ /,tsvLines="native"===source?eval(content):content,init=0),firstColumn=tsvLines[0].split(delimiter)[0],source="#chromosome"===firstColumn?"ncbi":"#chrom"===firstColumn?"ucsc":"native",tsvLinesLength=tsvLines.length,"ncbi"===source||"native"===source)for(i=init;i<tsvLinesLength;i++)columns=tsvLines[i].split(delimiter),chr=columns[0],void 0!==chromosomes&&-1===chromosomes.indexOf(chr)||(chr in lines==!1&&(lines[chr]=[]),stain=columns[7],columns[8]&&(stain+=columns[8]),line={chr:chr,bp:{start:parseInt(columns[5],10),stop:parseInt(columns[6],10)},iscn:{start:parseInt(columns[3],10),stop:parseInt(columns[4],10)},px:{start:-1,stop:-1,width:-1},name:columns[1]+columns[2],stain:stain,taxid:taxid},lines[chr].push(line));else if("ucsc"===source)for(i=init;i<tsvLinesLength;i++)columns=tsvLines[i].split(delimiter),columns[0]==="chr"+chromosomeName&&(stain=columns[4],"n/a"===stain&&(stain="gpos100"),start=parseInt(columns[1],10),stop=parseInt(columns[2],10),line={chr:columns[0].split("chr")[1],bp:{start:start,stop:stop},iscn:{start:start,stop:stop},px:{start:-1,stop:-1,width:-1},name:columns[3],stain:stain,taxid:taxid},lines[chr].push(line));return lines}function drawBandLabels(t){var e,n,r,i,o,a,s,c;o=this,r=[];for(i in t)for(n in t[i])r.push(t[i][n]);for(c={},s=0,e=0;e<r.length;e++)s+=1,a=r[e],n=d3.select(o.selector+" #"+a.id),c[a.id]=[],n.selectAll("text").data(a.bands).enter().append("g").attr("class",function(t,e){return"bandLabel bsbsl-"+e}).attr("transform",function(t){var n=o._layout.getChromosomeBandLabelTranslate(t,e),r=n.x;return c[a.id].push(r+13),n.translate}).append("text").attr("text-anchor",o._layout.getChromosomeBandLabelAnchor(e)).text(function(t){return t.name}),n.selectAll("line.bandLabelStalk").data(a.bands).enter().append("g").attr("class",function(t,e){return"bandLabelStalk bsbsl-"+e}).attr("transform",function(t){var e,n;return e=o.round(t.px.start+t.px.width/2),c[a.id].push(e+13),n=-10,"translate("+e+","+n+")"}).append("line").attr("x1",0).attr("y1",function(){return o._layout.getChromosomeBandTickY1(e)}).attr("x2",0).attr("y2",function(){return o._layout.getChromosomeBandTickY2(e)});for(e=0;e<r.length;e++){a=r[e];var u,f,l,h,d,p,g,m,b=c[a.id].length,_=[];for(u=0,m=5,f=0;f<b;f++)h=c[a.id][f],h<u+m==!1?(_.push(f),l!==f&&(p=c[a.id][f],g=36,d=p+g),h<d+m?(l=f,u=d):_.push(f)):(l=f,u=d);var v,y=[],w=_.length;for(v=0;v<w;v++)f=_[v],y.push("#"+a.id+" .bsbsl-"+f);this.bandsToShow=this.bandsToShow.concat(y)}}function getBandColorGradients(){var t,e,n,r,i,o,a="";t=[["gneg","#FFF","#FFF","#DDD"],["gpos25","#C8C8C8","#DDD","#BBB"],["gpos33","#BBB","#BBB","#AAA"],["gpos50","#999","#AAA","#888"],["gpos66","#888","#888","#666"],["gpos75","#777","#777","#444"],["gpos100","#444","#666","#000"],["acen","#FEE","#FEE","#FDD"],["noBands","#BBB","#BBB","#AAA"]];for(var s=0;s<t.length;s++)e=t[s][0],n=t[s][1],r=t[s][2],i=t[s][3],a+='<linearGradient id="'+e+'" x1="0%" y1="0%" x2="0%" y2="100%">',a+="gneg"===e?'<stop offset="70%" stop-color="'+r+'" /><stop offset="95%" stop-color="'+i+'" /><stop offset="100%" stop-color="'+n+'" />':'<stop offset="5%" stop-color="'+n+'" /><stop offset="15%" stop-color="'+r+'" /><stop offset="60%" stop-color="'+i+'" />',a+="</linearGradient>";return o='<style>svg#_ideogram  {padding-left: 5px;} svg#_ideogram .labeled {padding-left: 15px;} svg#_ideogram.labeledLeft {padding-left: 15px; padding-top: 15px;} #_ideogram text {font: 9px Tahoma; fill: #000;} #_ideogram .italic {font-style: italic;} #_ideogram .chromosome {cursor: pointer; fill: #AAA;}#_ideogram .chrSetLabel {font-weight: bolder;}#_ideogram .ghost {opacity: 0.2;}#_ideogram .hidden {display: none;}#_ideogram .bandLabelStalk line {stroke: #AAA; stroke-width: 1;}#_ideogram .syntenyBorder {stroke:#AAA;stroke-width:1;}#_ideogram .brush .selection {  fill: #F00;  stroke: #F00;  fill-opacity: .3;  shape-rendering: crispEdges;}#_ideogram .noBands {fill: #AAA;}#_ideogram .gneg {fill: #FFF}#_ideogram .gpos25 {fill: #BBB}#_ideogram .gpos33 {fill: #AAA}#_ideogram .gpos50 {fill: #888}#_ideogram .gpos66 {fill: #666}#_ideogram .gpos75 {fill: #444}#_ideogram .gpos100 {fill: #000}#_ideogram .gpos {fill: #000}#_ideogram .acen {fill: #FDD}#_ideogram .stalk {fill: #CCE;}#_ideogram .gvar {fill: #DDF}#_ideogram.faint .gneg {fill: #FFF}#_ideogram.faint .gpos25 {fill: #EEE}#_ideogram.faint .gpos33 {fill: #EEE}#_ideogram.faint .gpos50 {fill: #EEE}#_ideogram.faint .gpos66 {fill: #EEE}#_ideogram.faint .gpos75 {fill: #EEE}#_ideogram.faint .gpos100 {fill: #DDD}#_ideogram.faint .gpos {fill: #DDD}#_ideogram.faint .acen {fill: #FEE}#_ideogram.faint .stalk {fill: #EEF;}#_ideogram.faint .gvar {fill: #EEF}.gneg {fill: url("#gneg")} .gpos25 {fill: url("#gpos25")} .gpos33 {fill: url("#gpos33")} .gpos50 {fill: url("#gpos50")} .gpos66 {fill: url("#gpos66")} .gpos75 {fill: url("#gpos75")} .gpos100 {fill: url("#gpos100")} .gpos {fill: url("#gpos100")} .acen {fill: url("#acen")} .stalk {fill: url("#stalk")} .gvar {fill: url("#gvar")} .noBands {fill: url("#noBands")} .chromosome {fill: url("#noBands")} </style>',a+='<pattern id="stalk" width="2" height="1" patternUnits="userSpaceOnUse" patternTransform="rotate(30 0 0)"><rect x="0" y="0" width="10" height="2" fill="#CCE" /> <line x1="0" y1="0" x2="0" y2="100%" style="stroke:#88B; stroke-width:0.7;" /></pattern><pattern id="gvar" width="2" height="1" patternUnits="userSpaceOnUse" patternTransform="rotate(-30 0 0)"><rect x="0" y="0" width="10" height="2" fill="#DDF" /> <line x1="0" y1="0" x2="0" y2="100%" style="stroke:#99C; stroke-width:0.7;" /></pattern>',a="<defs>"+a+"</defs>",a=o+a}function processBandData(){var t,e,n,r,i,o,a,s,c,u,f,l,h,d,p=this;if(t=[],!0===p.config.multiorganism)for(p.coordinateSystem="bp",l=p.config.taxids,e=0;e<l.length;e++)f=l[e];else void 0===p.config.taxid&&(p.config.taxid=p.config.taxids[0]),f=p.config.taxid,l=[f],p.config.taxids=l;"chromosomes"in p.config&&(h=p.config.chromosomes),p.config.multiorganism&&(d=h),p.config.chromosomes={};var g=(new Date).getTime();for(n=0;n<l.length;n++)if(f=l[n],p.config.multiorganism&&(h=d[f]),"iscn"===p.coordinateSystem||p.config.multiorganism)for(c=p.bandData[f],u=p.getBands(c,f,h),h=Object.keys(u).sort(function(t,e){return Ideogram.naturalSort(t,e)}),p.config.chromosomes[f]=h.slice(),p.numChromosomes+=p.config.chromosomes[f].length,r=0;r<h.length;r++)i=h[r],o=u[i],t.push(o),a={iscn:o[o.length-1].iscn.stop,bp:o[o.length-1].bp.stop},a.iscn>p.maxLength.iscn&&(p.maxLength.iscn=a.iscn),a.bp>p.maxLength.bp&&(p.maxLength.bp=a.bp);else if("bp"===p.coordinateSystem)for(p.config.chromosomes[f]=h.slice(),p.numChromosomes+=p.config.chromosomes[f].length,r=0;r<h.length;r++)s=h[r],s.length>p.maxLength.bp&&(p.maxLength.bp=s.length);var m=(new Date).getTime();return p.config.debug&&console.log("Time in processBandData: "+(m-g)+" ms"),t}__webpack_require__.d(__webpack_exports__,"c",function(){return getBands}),__webpack_require__.d(__webpack_exports__,"a",function(){return drawBandLabels}),__webpack_require__.d(__webpack_exports__,"b",function(){return getBandColorGradients}),__webpack_require__.d(__webpack_exports__,"d",function(){return processBandData});var __WEBPACK_IMPORTED_MODULE_0_d3_selection__=__webpack_require__(0),_typeof="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t},d3=Object.assign({},__WEBPACK_IMPORTED_MODULE_0_d3_selection__)},function(t,e,n){"use strict";function r(){call(this.onBrushMoveCallback)}function i(t,e){function n(){var t=o.event.selection.map(d.invert),e=Math.floor(t[0]),n=Math.ceil(t[1]);a.selectedRegion={from:e,to:n,extent:n-e},a.onBrushMove&&a.onBrushMoveCallback()}var r,i,a=this,s=a.config.chrWidth+6.5,c=a.config.chrHeight,f=a.chromosomesArray[0],l=f.bands[f.bands.length-1].bp.stop,h=this._layout.getMargin().left,d=u.scaleLinear().domain([0,u.max(f.bands,function(t){return t.bp.stop})]).range([h,u.max(f.bands,function(t){return t.px.stop})+h]);void 0===t&&(t=Math.floor(l/10)),"undefined"==typeof right&&(e=Math.ceil(2*t)),r=a.convertBpToPx(f,t),i=a.convertBpToPx(f,e),a.selectedRegion={from:t,to:e,extent:e-t},a.brush=u.brushX().extent([[h,0],[c+h,s]]).on("brush",n);var p=this._layout.getChromosomeSetYTranslate(0),g=p+(a.config.chrWidth-s)/2;u.select(a.selector).append("g").attr("class","brush").attr("transform","translate(0, "+g+")").call(a.brush).call(a.brush.move,[r,i])}n.d(e,"b",function(){return r}),n.d(e,"a",function(){return i});var o=n(0),a=n(50),s=n(64),c=n(4),u=Object.assign({},a,o);u.scaleLinear=s.a,u.max=c.d},function(t,e,n){"use strict";function r(t,e,n,r,i,o){var a,s,c,u,f,l,h,d=this;for(h="male"===d.config.sex?[1,0]:[0,0],l=0;l<h.length;l++)f=h[l]+i,a=o[f],s=t[f],c=d.getChromosomeModel(s,a,e,f),u=d.drawChromosome(c,i,n,l),r.append("clipPath").attr("id",c.id+"-chromosome-set-clippath").selectAll("path").data(u).enter().append("path").attr("d",function(t){return t.path}).attr("class",function(t){return t.class})}function i(t){if(2===this.config.ploidy&&this.config.sex){var e,n,r=this,i={X:1,Y:1};for(r.sexChromosomes.list=[],n=0;n<t.length;n++)e=t[n],"male"===r.config.sex&&e in i?(r.sexChromosomes.list.push(e),r.sexChromosomes.index||(r.sexChromosomes.index=n)):"X"===e&&(r.sexChromosomes.list.push(e,e),r.sexChromosomes.index=n)}}n.d(e,"a",function(){return r}),n.d(e,"b",function(){return i})},function(t,e,n){"use strict";function r(t,e){var n,r,i,o,a,s,c,u,f,l,h,d,p;for(n=0;n<t.bands.length;n++)if(r=t.bands[n],a=this._bandsXOffset,h=r.bp.start,d=r.bp.stop,p=d-h,u=r.iscn.start,f=r.iscn.stop,l=f-u,s=r.px.start,c=r.px.width,e>=h&&e<=d)return i=l/p,o=u+(e-h)*i,a+s+c*(o-u)/l;throw new Error("Base pair out of range.  bp: "+e+"; length of chr"+t.name+": "+r.bp.stop)}function i(t,e){var n,r,i,o,a,s,c,u,f,l,h,d;for(0===e&&(e=t.bands[0].px.start),n=0;n<t.bands.length;n++)if(r=t.bands[n],c=r.px.start,u=r.px.stop,f=r.iscn.start,l=r.iscn.stop,e>=c&&e<=u)return d=l-f,s=u-c,h=r.bp.stop-r.bp.start,i=d/s,o=f+(e-c)*i,a=r.bp.start+h*(o-f)/d,Math.round(a);throw new Error("Pixel out of range.  px: "+e+"; length of chr"+t.name+": "+u)}n.d(e,"a",function(){return r}),n.d(e,"b",function(){return i})},function(t,e,n){"use strict";function r(){return"assembly"in this.config&&/(GCF_|GCA_)/.test(this.config.assembly)}function i(){var t,e,n,r=document.scripts,i=location.host,o=Ideogram.version;if("localhost"!==i&&"127.0.0.1"!==i)return"https://unpkg.com/ideogram@"+o+"/dist/data/bands/native/";for(var a=0;a<r.length;a++)if("src"in(t=r[a])&&/ideogram/.test(t.src.split("/").slice(-1)))return e=t.src.split("//"),n=e[0],e="/"+e[1].split("/").slice(0,-2).join("/"),n+"//"+e+"/data/bands/native/";return"../data/bands/native/"}function o(t,e,n,r){var i,o,a,s,c,u,f={},l=this.config.chrHeight,h=this.maxLength;if(c=this.coordinateSystem,u=void 0!==t,u?(f.name=e,f.length=t[t.length-1][c].stop,f.type="nuclear"):f=e,f.chrIndex=r,f.id="chr"+f.name+"-"+n,!0===this.config.fullChromosomeLabels){var d=this.organisms[n].scientificNameAbbr;f.name=d+" chr"+f.name}if(s=f.length,a=0,u)for(var p=0;p<t.length;p++){i=t[p];var g=i[c].stop-i[c].start;o=l*f.length/h[c]*g/s,t[p].px={start:a,stop:a+o,width:o},a=t[p].px.stop,u&&"acen"===i.stain&&"p"===i.name[0]&&(f.pcenIndex=p)}else a=l*f.length/h[c];return f.width=a,f.scale={},!0===this.config.multiorganism?(f.scale.bp=1,f.scale.iscn=l*s/h.bp):(f.scale.bp=l/h.bp,u&&(f.scale.iscn=l/h.iscn)),f.bands=t,f.centromerePosition="",u&&"p"===t[0].name[0]&&"q"===t[1].name[0]&&t[0].bp.stop-t[0].bp.start<2e6&&(f.centromerePosition="telocentric",f.bands=f.bands.slice(1)),u&&1===f.bands.length&&delete f.bands,f}function a(){var t=this,e=t._layout.getChromosomeLabelClass(),n=t._layout.getChromosomeSetLabelXPosition(),r=t._layout.getChromosomeSetLabelTranslate();g.selectAll(t.selector+" .chromosome-set-container").append("text").data(t.chromosomesArray).attr("class","chromosome-set-label "+e).attr("transform",r).attr("x",n).attr("y",function(e,n){return t._layout.getChromosomeSetLabelYPosition(n)}).attr("text-anchor",t._layout.getChromosomeSetLabelAnchor()).each(function(e,n){var r;r=-1===e.name.indexOf(" ")?[e.name]:e.name.match(/^(.*)\s+([^\s]+)$/).slice(1).reverse(),"sex"in t.config&&2===t.config.ploidy&&n===t.sexChromosomes.index&&(r="male"===t.config.sex?["XY"]:["XX"]),g.select(this).selectAll("tspan").data(r).enter().append("tspan").attr("dy",function(t,e){return-1.2*e+"em"}).attr("x",t._layout.getChromosomeSetLabelXPosition()).attr("class",function(e,n){var r=t.config.fullChromosomeLabels;return 1===n&&r?"italic":null}).text(String)});var i=t._layout.getChromosomeSetLabelTranslate();g.selectAll(t.selector+" .chromosome-set-container").each(function(e,n){g.select(this).selectAll(".chromosome").append("text").attr("class","chrLabel").attr("transform",i).attr("x",function(e,n){return t._layout.getChromosomeLabelXPosition(n)}).attr("y",function(e,n){return t._layout.getChromosomeLabelYPosition(n)}).text(function(e,r){return t._ploidy.getAncestor(n,r)}).attr("text-anchor","middle")})}function s(t,e,n,r){var i,o,a,s,c,u,f,l,h;if(o=this.config.chrWidth,i=this.config.chrMargin*e,u=this.config.numAnnotTracks,a=this,void 0===r||!r.hasOwnProperty("x")||1===r.x&&1===r.y?(s=-8,c=-16,r={x:1,y:1},f=""):(f="scale("+r.x+","+r.y+")",s=-6,c=""===r?-16:-14),"vertical"===n||""===n){var d=e-1;(u>1||""===n)&&(d-=1),h=-4,!0===a.config.showBandLabels&&(h=a.config.chrMargin+o+26),i=a.config.chrMargin*d,u>1==!1&&(i+=1),c=i+h,t.selectAll("text.chrLabel").attr("transform",f).selectAll("tspan").attr("x",s).attr("y",c)}else e-=1,h=-o-2,!0===a.config.showBandLabels&&(h=a.config.chrMargin+8),l=a.config.annotTracksHeight,"overlay"!==a.config.annotationsLayout&&(l*=2),i=a.config.chrMargin*e,s=3-(i+h)+l,s/=r.x,t.selectAll("text.chrLabel").attr("transform","rotate(-90)"+f).selectAll("tspan").attr("x",s).attr("y",c)}function c(t){return Math.round(100*t)/100}function u(t,e,n,r){var i=this.config.chrMargin,o=d.a.getInstance(t),a=n.append("g").attr("id",t.id).attr("class","chromosome "+o.getCssClass()).attr("transform","translate(0, "+r*i+")");return p.a.getInstance(o,this.config,this).render(a,e,r)}function f(t){if(this.config.taxid){var e=Number(g.select(t.parentNode).attr("data-set-number")),n=Array.prototype.slice.call(g.select(t.parentNode).selectAll("g.chromosome")._groups[0]).indexOf(t);return this._layout.rotate(e,n,t)}}function l(){return g.select(this.selector).node()}n.d(e,"a",function(){return r}),n.d(e,"e",function(){return i}),n.d(e,"d",function(){return o}),n.d(e,"c",function(){return a}),n.d(e,"h",function(){return s}),n.d(e,"i",function(){return c}),n.d(e,"b",function(){return u}),n.d(e,"g",function(){return f}),n.d(e,"f",function(){return l});var h=n(0),d=n(260),p=n(261),g=Object.assign({},h)},function(t,e,n){"use strict";function r(t,e){if(!t)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return!e||"object"!=typeof e&&"function"!=typeof e?t:e}function i(t,e){if("function"!=typeof e&&null!==e)throw new TypeError("Super expression must either be null or a function, not "+typeof e);t.prototype=Object.create(e&&e.prototype,{constructor:{value:t,enumerable:!1,writable:!0,configurable:!0}}),e&&(Object.setPrototypeOf?Object.setPrototypeOf(t,e):t.__proto__=e)}function o(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}n.d(e,"a",function(){return s});var a=function(){function t(t,e){for(var n=0;n<e.length;n++){var r=e[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),s=function(){function t(e){o(this,t),this._model=e,this._class="ModelAdapter"}return a(t,[{key:"getModel",value:function(){return this._model}},{key:"getCssClass",value:function(){return""}}],[{key:"getInstance",value:function(e){return e.bands?new t(e):new c(e)}}]),t}(),c=function(t){function e(t){o(this,e);var n=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t));return n._class="ModelNoBandsAdapter",n}return i(e,t),a(e,[{key:"getModel",value:function(){return this._model.bands=[],this._model.width>1&&this._model.bands.push({name:"q",px:{start:0,stop:this._model.width,width:this._model.width}}),this._model}},{key:"getCssClass",value:function(){return"noBands"}}]),e}(s)},function(t,e,n){"use strict";function r(t,e){if(!t)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return!e||"object"!=typeof e&&"function"!=typeof e?t:e}function i(t,e){if("function"!=typeof e&&null!==e)throw new TypeError("Super expression must either be null or a function, not "+typeof e);t.prototype=Object.create(e&&e.prototype,{constructor:{value:t,enumerable:!1,writable:!0,configurable:!0}}),e&&(Object.setPrototypeOf?Object.setPrototypeOf(t,e):t.__proto__=e)}function o(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}n.d(e,"a",function(){return u});var a=n(262),s=n(263),c=function(){function t(t,e){for(var n=0;n<e.length;n++){var r=e[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),u=function(){function t(e,n,r){o(this,t),this._adapter=e,this._model=this._adapter.getModel(),this._config=n,this._ideo=r,this._color=new a.a(this._config),this._bumpCoefficient=5}return c(t,[{key:"_addPArmShape",value:function(t,e){return e?t.concat(this._getPArmShape()):t}},{key:"_addQArmShape",value:function(t,e){return e?t.concat(this._getQArmShape()):t}},{key:"render",value:function(t,e,n){var r=this;t=t.append("g").attr("class","bands").attr("clip-path","url(#"+this._model.id+"-chromosome-set-clippath)");var i=this._renderPArm(t,e,n),o=this._renderQArm(t,e,n);this._renderRangeSet(t,e,n);var a=[];a=this._addPArmShape(a,i),a=this._addQArmShape(a,o);var s="0",c="",u=this.isFullyBanded();return"ancestors"in this._ideo.config&&!("rangeSet"in this._ideo.config)?(c=r._color.getArmColor(e,n,0),u&&(s="0.5")):u?(s=null,c="transparent"):"ancestors"in this._ideo.config||(s="1"),t.append("g").attr("class","chromosome-border").selectAll("path").data(a).enter().append("path").attr("fill",c).style("fill-opacity",s).attr("stroke",function(t,i){return r._color.getBorderColor(e,n,i)}).attr("stroke-width",function(t){return"strokeWidth"in t?t.strokeWidth:1}).attr("d",function(t){return t.path}).attr("class",function(t){return t.class}),a}},{key:"_renderRangeSet",value:function(t,e,n){if("rangeSet"in this._config){var r=this._config.rangeSet.filter(function(t){return t.chr-1===e}).map(function(t){return new s.a(t)}),i=t.append("g").attr("class","range-set"),o=this,a=o._ideo,c=a._bandsXOffset;i.selectAll("rect.range").data(r).enter().append("rect").attr("class","range").attr("x",function(t){return a.convertBpToPx(o._model,t.getStart())-c}).attr("y",0).attr("width",function(t){return a.convertBpToPx(o._model,t.getLength())-c}).attr("height",this._config.chrWidth).style("fill",function(t){return t.getColor(n)})}}},{key:"_getShapeData",value:function(){for(var t,e=0;e<this._model.bands.length;e++)if("q"===this._model.bands[e].name[0]){t=this._model.bands[e];break}var n=this._model.bands.length-1,r=this._model.bands[n].px.stop;return{x1:0,x2:t?t.px.start:r,x3:r,w:this._config.chrWidth,b:this._config.chrWidth/this._bumpCoefficient}}},{key:"_getPArmShape",value:function(){var t=this._getShapeData(),e=t.x2-t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+t.b+",0 L"+e+",0 Q"+(t.x2+t.b)+","+t.w/2+","+e+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"}:[{class:"",path:"M"+t.b+",0 L"+(e-2)+",0 L"+(e-2)+","+t.w+" L"+t.b+","+t.w+" Q-"+t.b+","+t.w/2+","+t.b+",0"},{class:"acen",path:"M"+e+",0 Q"+(t.x2+t.b)+","+t.w/2+","+e+","+t.w+" L"+e+","+t.w+" L"+(e-2)+","+t.w+" L"+(e-2)+",0"}]}},{key:"_getQArmShape",value:function(){var t=this._getShapeData(),e=t.x3-t.b,n=t.x2+t.b;return this.isFullyBanded()||"ancestors"in this._ideo.config?{class:"",path:"M"+n+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+n+","+t.w+" Q"+(t.x2-t.b)+","+t.w/2+","+n+",0"}:[{path:"M"+n+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+n+","+t.w+" L"+n+",0"},{class:"acen",path:"M"+n+",0Q"+(t.x2-t.b)+","+t.w/2+","+n+","+t.w+" L"+n+","+t.w+"L"+(n+2)+","+t.w+"L"+(n+2)+",0"}]}},{key:"isFullyBanded",value:function(){return this._model.bands&&(2!==this._model.bands.length||"q"===this._model.bands[0].name[0])}},{key:"_renderBands",value:function(t,e,n,r,i){var o=this,a="p"===i?0:1,s="";"ancestors"in o._ideo.config&&!o.isFullyBanded()&&(s=o._color.getArmColor(e,n,a)),t.selectAll("path.band."+i).data(r).enter().append("path").attr("id",function(t){return o._model.id+"-"+t.name.replace(".","-")}).attr("class",function(t){return"band "+i+"-band "+t.stain}).attr("d",function(t){var e=o._ideo.round(t.px.start),n=o._ideo.round(t.px.width);return"M "+e+", 0l "+n+" 0 l 0 "+o._config.chrWidth+" l -"+n+" 0 z"}).style("fill",s)}},{key:"_renderPArm",value:function(t,e,n){var r=this._model.bands.filter(function(t){return"p"===t.name[0]});return this._renderBands(t,e,n,r,"p"),Boolean(r.length)}},{key:"_renderQArm",value:function(t,e,n){var r=this._model.bands.filter(function(t){return"q"===t.name[0]});return this._renderBands(t,e,n,r,"q"),Boolean(r.length)}}],[{key:"getInstance",value:function(t,e,n){return"telocentric"===t.getModel().centromerePosition?new l(t,e,n):new f(t,e,n)}}]),t}(),f=function(t){function e(t,n,i){o(this,e);var a=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t,n,i));return a._class="MetacentricChromosome",a}return i(e,t),e}(u),l=function(t){function e(t,n,i){o(this,e);var a=r(this,(e.__proto__||Object.getPrototypeOf(e)).call(this,t,n,i));return a._class="TelocentricChromosome",a._pArmOffset=3,a}return i(e,t),c(e,[{key:"_addPArmShape",value:function(t){return t.concat(this._getPArmShape())}},{key:"_getPArmShape",value:function(){var t=this._getShapeData();return t.o=this._pArmOffset,[{class:"acen",path:"M"+(t.x2+2)+",1L"+(t.x2+t.o+3.25)+",1 L"+(t.x2+t.o+3.25)+","+(t.w-1)+" L"+(t.x2+2)+","+(t.w-1)},{class:"gpos66",path:"M"+(t.x2-t.o+5)+",0L"+(t.x2-t.o+3)+",0 L"+(t.x2-t.o+3)+","+t.w+" L"+(t.x2-t.o+5)+","+t.w,strokeWidth:.5}]}},{key:"_getQArmShape",value:function(){var t=this._getShapeData(),e=t.x3-t.b,n=this._pArmOffset+3;return{class:"",path:"M"+(t.x2+n)+",0 L"+e+",0 Q"+(t.x3+t.b)+","+t.w/2+","+e+","+t.w+" L"+(t.x2+n)+","+t.w}}}]),e}(u)},function(t,e,n){"use strict";function r(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}n.d(e,"a",function(){return a});var i=n(90),o=function(){function t(t,e){for(var n=0;n<e.length;n++){var r=e[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),a=function(){function t(e){r(this,t),this._config=e,this._ploidy=new i.a(this._config)}return o(t,[{key:"getArmColor",value:function(t,e,n){return this._config.armColors?this._config.armColors[n]:this._config.ancestors?this._getPolyploidArmColor(t,e,n):null}},{key:"getBorderColor",value:function(t,e,n){return e<this._config.ploidy?"#000":this._ploidy.exists(t,e,n)?"#000":"#fff"}},{key:"_getPolyploidArmColor",value:function(t,e,n){if(this._ploidy.exists(t,e,n)){var r=this._ploidy.getAncestor(t,e,n);return this._config.ancestors[r]}return"transparent"}}]),t}()},function(t,e,n){"use strict";function r(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a function")}n.d(e,"a",function(){return o});var i=function(){function t(t,e){for(var n=0;n<e.length;n++){var r=e[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(t,r.key,r)}}return function(e,n,r){return n&&t(e.prototype,n),r&&t(e,r),e}}(),o=function(){function t(e){r(this,t),this._data=e}return i(t,[{key:"getStart",value:function(){return this._data.start}},{key:"getStop",value:function(){return this._data.stop}},{key:"getLength",value:function(){return this._data.stop-this._data.start}},{key:"getColor",value:function(t){return"ploidy"in this._data?"ploidy"in this._data&&this._data.ploidy[t]?this._getColor(t):"transparent":this._getColor(t)}},{key:"_getColor",value:function(t){return Array.isArray(this._data.color)?this._data.color[t]:this._data.color}}]),t}()}]);
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