gpml2pvjson
Version:
convert GPML (XML) to pvjson (json)
1 lines • 225 kB
JSON
{"pathway":{"@context":["https://cdn.rawgit.com/wikipathways/WpVocabularies/7a46a05/contexts/pvjs.jsonld"],"fill":"white","strokeWidth":0,"stroke":"black","contains":["ida37f0fc3","id4a00e28c","id93be2059","e5485","df85c","a470a","ba74c","e710f","e36e7","e7d6e","c2b95","d6f08","af4e7","e8a56","eaf62","c577c","a4b7e","ab1e3","f9565","ad284","b05b6","abfb4","b025a","f6cbe","fcd13","e2710","dd267","a14d9","bb302","a7bfd","a5ac6","e6f1a","c182a","da45c","fa70f","a5aea","e0398","cad51","fd47a","b1c90","c1385","abeb5","dedf5","fee0a","bc666","b6c1d","e5834","cce33","dc4ee","bd32b","a8d56","ba29c","e3834","ffb63","d7e26","eae49","f4398","e14eb","b5342","d20b7","d7c22","b13c9","d94d8","c9c1d","caef7","b8e48","beaf3","abb38","d5861","b5c2a","deb56","b56d4","e984d","a326a","c8fd5","a87cc","a11e5","be773","e9472","b26c8","c203c","bd31a","d7f5b","b0c77","ce487","b5afc","cc9e9","c4461","d5690","c5d19","c5090","be8f0","f6780","c7b53","dc7c0","bbcee","cf170","ffa91","e19a3","f5fb5","c552b","ed559","af980","cb081","b6c07","cca26","a4eab","f4c60","e75f4","aa362","ce4b5","c267d","f69ac","c332a","a92fb","b84f3","e795d","c722f","f9753","e3b92","d91f9","da824","aa169","c5700","d72c4","a1e93","e417c","c909a","fecb6","bacbc","aa2ee","aafe9","d4106","ef9f0","c6362","b9d0c","e5ea0","d0872","f9925","ba679","d8bf7","dca06","b692e","ad196","e59fe","b874b","fc979"],"drawAs":"rect","gpmlElementName":"Pathway","height":1009.4964838255978,"kaavioType":"Group","name":"ATM Signaling Pathway","padding":5,"type":["Pathway","http://identifiers.org/pw/PW:0000292","http://identifiers.org/pw/PW:0001361","http://identifiers.org/pw/PW:0000651","http://identifiers.org/pw/PW:0000287"],"width":1147.4353856445682,"x":0,"y":0,"zIndex":0,"fontSize":12,"fontWeight":"bold","textAlign":"left","verticalAlign":"top","comments":[{"source":"WikiPathways-description","content":"Ataxia-telangiectasia (A-T) is a highly pleiotropic, autosomal recessive disease that leads to multisystem defects and has an intricate cellular phenotype, all linked to the functional inactivation of a single gene. Extensive research on the phenotype and the recent discovery and cloning of the responsible gene point to a defect as a central biochemical locus which links several signal transduction pathways that operate under stress as well as in normal physiological conditions.\r\n\r\nAtaxia is the first symptom in all patients and is predominantly truncal, first manifested in swaying of the head and trunk on standing and even sitting. Truncal ataxia precedes appendicular cerebellar disease. In the first years of life, certain manifestations are present such as dysarthria, muscular hypotonia, the slow initiation and performance of all voluntary movements, characteristic hypotonic facies and postures, and drooling. Dyssynergia and intention tremor of the upper extremities become a major feature after the fifth year of life. The tendon reflexes are diminished or lost, but may be normal or even hyperactive in the early stages. All these observations show a clear ataxia of cerebellar type, initially of station and gait, and later of intention. Early observations of brains from patients with A-T showed neurodegenerative changes, particularly in the Purkinje and granular cells of the cerebellum. Neuronal degeneration is also present in the brainstem, and dentate and olivary nuclei atrophy. Neuronal loss occurs in the substantial nigra and oculomotor nuclei, dorsal root ganglia, and degenerative changes are evident in spinal motor neurons, and dorsal root and sympathetic motor neurons. Moreover, multiple abnormalities in Purkinje cell development have been observed in an Atm-deficient mouse model. Misplaced Purkinje cells have been observed in both the granular and molecular cell layers. In addition, Purkinje cell dendrites tend to grow laterally instead of extending towards the surface of the cerebellum.\r\n\r\nATM (for Ataxia-telangiectasia mutated) has been located by restriction-fragment length polymorphism in the chromosome 11, location: 108,093,211-108,239,829. Interestingly, the site of ATM is the same or adjacent to the region occupied by CD3 (Antigen, Delta subunit), THY1 (T-Cell antigen), and NCAM (Cell Adhesion Molecule, Neural, 1) genes, all of which are members of the immunoglobulin-gene superfamily and consequently may be subject to the same defect that afflicts the T-cell receptor and immunoglobulin molecules in A-T. The ATM gene presents an open reading frame (ORF) of 9,165 kb cDNA and is constituted by 66 exons spread over 150 kb of genomic DNA which has a transcript of 12 kb. The ORF of this transcript predicts a 370-kDa protein composed of 3056 amino acids. Over 300 mutations have been found in A-T patients, distributed across the full length (150 kb of genomic DNA) of the ATM gene.\r\n\r\nSequence homology indicates that the atm gene product falls into a family of proteins that are related to the catalytic subunit of phosphatidylinositol 3-kinase (PI 3-kinase). This family includes TEL1, MEC1, TOR1, and TOR2 of the budding yeast Saccharomyces cerevisiae, RAD3 of the fission yeast Schizosaccharomyces pombe, and MEI-41 of Drosophila melanogaster. The mammalian family member most closely related to ATM is the ATR/FRP1 protein and, like its yeast homologs, it mediates cellular responses to unreplicated or damaged DNA. In humans the PI 3-kinase family includes the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) and FRAP. These sequence homologies appear to reflect functional homology because many of the PI 3-kinase family members are involved in DNA repair, recombination and cell cycle control. Despite the resemblance to lipid kinases, members of this family, including ATM, possess a serine/threonine protein kinase activity, which is wortmannin sensitive.\r\n\r\nATM phosphoprotein is ubiquitously expressed and predominantly found in nuclei of proliferating cells, but subcellular fractionation and immunofluorescence revealed that 10-20% of the protein is present in cytoplasmic vesicles, including peroxisomes and endosomes and a prominent cytoplasmic fraction in mouse oocytes. ATM is endosome-bound in mouse neurons, suggesting molecular sorting of the protein occurs in the cytoplasm. In Purkinje cells, distribution of ATM protein is primarily in cytoplasm, and this may be related to the differentiation state of the cells. ATM mRNA is present in all human and mouse tissues. In situ hybridization shows that ATM mRNA is expressed throughout the whole mouse embryo. Furthermore, ATM has been associated with خ²-adaptin in lymphoblast vesicles indicating that it may play a role in intracellular vesicle and/or protein transport mechanisms. No obvious nuclear localization signals have been detected in ATM. Neither an ectopically expressed N-terminal fragment of the protein nor a C-terminal fragment is capable of entering the nucleus."}],"author":"Arturo Manzo-Fontes","organism":"Homo sapiens","standardName":"ATM Signaling Pathway","displayName":"ATM Signaling Pathway","textContent":"Name: ATM Signaling Pathway\nOrganism: Homo sapiens","isSimilarTo":"http://wikipathways.org/index.php/Special:SearchPathways?query=ATM%20Signaling%20Pathway&species=Homo%20sapiens&doSearch=1","id":"hash://sha256/8693549c142ca1442416779a2982bb163ac5b21c41f68a693ec73563622d13fe"},"entitiesById":{"ed2e6":{"textContent":"Chk2","id":"ed2e6","wpType":"Protein","citations":["publicationXrefc00","publicationXreff8d","publicationXrefec6","publicationXreff92","publicationXrefc47","publicationXrefe2a","publicationXrefa9a"],"x":8,"y":25.584104344113825,"width":43,"height":20,"zIndex":33033,"fill":"#66ccff","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"O96017","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:O96017","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"e710f"},"d1a55":{"id":"d1a55","x":8,"y":8,"width":208.78997407087286,"height":92,"zIndex":16384,"fontSize":10,"verticalAlign":"middle","drawAs":"rect","rotation":0,"textAlign":"center","stroke":"#000000","fill":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"e5485"},"d2463":{"textContent":"Cell response","id":"d2463","x":118.38893690579175,"y":34.339275917310374,"width":71.11495246326592,"height":20,"zIndex":28672,"fill":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"left","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"e5485"},"d12a1":{"textContent":"CDC25A","id":"d12a1","wpType":"GeneProduct","x":9.446212385375816,"y":25.140308540765545,"width":56,"height":23,"zIndex":33035,"fill":"#990099","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000164045","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000164045","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"bbcee"},"f3789":{"id":"f3789","x":8.72850122850059,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32875,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"a470a"},"bc294":{"textContent":"P","id":"bc294","x":8,"y":8,"width":19,"height":20,"zIndex":32876,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"a470a"},"cf170":{"textContent":"DNA\nRepair","id":"cf170","wpType":"Pathway","x":403.21894920457385,"y":482.8115308353242,"width":56,"height":33,"zIndex":33036,"fontWeight":"bold","fontSize":12,"verticalAlign":"middle","drawAs":"none","stroke":"#003399","textAlign":"center","fill":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"WikiPathways","xrefIdentifier":"WP707","type":["DataNode","SingleFreeNode","WikiPathways:WP707","Pathway"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"b37e1":{"id":"b37e1","x":34.83622406816926,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32877,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"ba74c"},"c4e11":{"textContent":"P","id":"c4e11","x":34.10772283966867,"y":8,"width":19,"height":20,"zIndex":32878,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"ba74c"},"ffa91":{"textContent":"Cyclin B","id":"ffa91","wpType":"GeneProduct","citations":["publicationXrefa23","publicationXrefc1b","publicationXrefd45","publicationXrefe3f","publicationXreffe4"],"x":204.18969380134422,"y":554,"width":52.23749066467513,"height":24.575056011949144,"zIndex":33037,"fill":"#00ffff","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Entrez Gene","xrefIdentifier":"891","type":["DataNode","SingleFreeNode","Entrez Gene:891","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ea31e":{"id":"ea31e","x":26.205248968332626,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32879,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"e710f"},"c958b":{"textContent":"P","id":"c958b","x":25.476747739832035,"y":8,"width":19,"height":20,"zIndex":32880,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"e710f"},"e19a3":{"textContent":"GADD45A","id":"e19a3","wpType":"GeneProduct","citations":["publicationXrefd0e","publicationXrefd3d","publicationXrefbd3","publicationXrefc38","publicationXreffc4","publicationXrefc91"],"x":261.9633593917388,"y":503.5380972079269,"width":63.94007185877967,"height":35.52951820434859,"zIndex":33038,"fill":"#cc9900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Entrez Gene","xrefIdentifier":"1647","type":["DataNode","SingleFreeNode","Entrez Gene:1647","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"bf128":{"id":"bf128","x":8.72850122850059,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32881,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"e36e7"},"b6133":{"textContent":"P","id":"b6133","x":8,"y":8,"width":19,"height":20,"zIndex":32882,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"e36e7"},"ee34e":{"textContent":"CREB1","id":"ee34e","wpType":"GeneProduct","citations":["publicationXreff37"],"x":8.344483564635425,"y":25.74330378581044,"width":49,"height":20,"zIndex":33039,"fill":"#66ff66","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Entrez Gene","xrefIdentifier":"1385","type":["DataNode","SingleFreeNode","Entrez Gene:1385","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"f5fb5"},"d1aba":{"id":"d1aba","x":35.04329450707996,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32883,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"e7d6e"},"e11ac":{"textContent":"P","id":"e11ac","x":34.31479327857937,"y":8,"width":19,"height":20,"zIndex":32884,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"e7d6e"},"c552b":{"textContent":"p21","id":"c552b","wpType":"GeneProduct","citations":["publicationXrefb43","publicationXrefe9a","publicationXrefcf3","publicationXrefbfb","publicationXrefcaa","publicationXrefded"],"x":62.24676760677477,"y":547.7840376383515,"width":34.7173294252834,"height":34.45081147513861,"zIndex":33040,"fill":"#66ccff","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"left","drawAs":"PentagonPathVisio","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000124762","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000124762","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"aeb39":{"id":"aeb39","x":43.61692076867985,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32885,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"c2b95"},"b8abd":{"textContent":"P","id":"b8abd","x":42.88841954017926,"y":8,"width":19,"height":20,"zIndex":32886,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"c2b95"},"ed559":{"textContent":"TP73","id":"ed559","wpType":"GeneProduct","citations":["publicationXreff03","publicationXrefe12","publicationXrefdc4","publicationXrefd7a","publicationXrefe7f","publicationXrefa13"],"x":706.75,"y":636.25,"width":46.25,"height":20,"zIndex":33041,"fill":"#00cccc","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000078900","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000078900","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"c78ec":{"id":"c78ec","x":8.72850122850059,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32887,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"d6f08"},"bbba7":{"textContent":"P","id":"bbba7","x":8,"y":8,"width":19,"height":20,"zIndex":32888,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"d6f08"},"b6896":{"textContent":"NEMO","id":"b6896","wpType":"Protein","citations":["publicationXrefb67","publicationXrefe40"],"x":12.000000000000455,"y":31.87899740708781,"width":36.54278305963707,"height":20,"zIndex":33042,"fill":"#00cc00","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"Q9Y6K9","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:Q9Y6K9","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"af980"},"c5528":{"id":"c5528","x":31.393643932008217,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":32889,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"af4e7"},"b90d8":{"textContent":"P","id":"b90d8","x":30.665142703507172,"y":8,"width":19,"height":20,"zIndex":32890,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"af4e7"},"d1775":{"textContent":"CDC25C","id":"d1775","wpType":"GeneProduct","citations":["publicationXreff20","publicationXrefbaf","publicationXrefc15","publicationXrefd31","publicationXrefed4","publicationXrefcad"],"x":8,"y":25.402583465964653,"width":63,"height":20,"zIndex":33043,"fill":"#ff00ff","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000158402","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000158402","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"cb081"},"c4385":{"id":"c4385","x":9.707481931239272,"y":9.114250614250409,"width":17.5,"height":16.5,"zIndex":32891,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"e8a56"},"f4ff6":{"textContent":"P","id":"f4ff6","x":8.978980702738681,"y":8,"width":19,"height":20,"zIndex":32892,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"e8a56"},"b6c07":{"textContent":"SMC1A","id":"b6c07","wpType":"Protein","citations":["publicationXrefb80"],"x":944.5297459146173,"y":208.49609097370282,"width":50.5210382526715,"height":24.994573701427782,"zIndex":33044,"fill":"#00cc00","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","stroke":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"Q14683","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:Q14683","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ce487":{"id":"ce487","cellularComponent":"Cell","strokeStyle":"double","x":14.424713005334183,"y":55.60788510091152,"width":1104.510672639234,"height":925.3885987246863,"zIndex":33021,"fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"strokeWidth":3,"stroke":"#999999","rotation":0,"textAlign":"center","fill":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode","PhysicalEntity","CellularComponent","Cell"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"b5afc":{"textContent":"IR Radiation","id":"b5afc","x":392.42592592592564,"y":17.41666666666663,"width":80,"height":20,"zIndex":33022,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"cca26":{"textContent":"Apoptosis","id":"cca26","wpType":"Pathway","citations":["publicationXrefb0a","publicationXrefc88","publicationXrefe65","publicationXrefdca","publicationXrefdec","publicationXreff18","publicationXrefb29","publicationXrefad1","publicationXrefd3a","publicationXrefdfc"],"x":83.38364563952757,"y":380.54686671557056,"width":80,"height":20,"zIndex":33045,"fontWeight":"bold","fontSize":12,"verticalAlign":"middle","drawAs":"none","stroke":"#003399","textAlign":"center","fill":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"WikiPathways","xrefIdentifier":"WP254","type":["DataNode","SingleFreeNode","WikiPathways:WP254","Pathway"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"c40e8":{"id":"c40e8","x":8.728501228500818,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":33028,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"be8f0"},"cc9e9":{"textContent":"MDMX Ubiquitination &\nDegradation","id":"cc9e9","x":153,"y":705,"width":148.45804596270244,"height":39.50195878163481,"zIndex":33023,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"a4eab":{"textContent":"AP3B2","id":"a4eab","wpType":"Protein","x":754.5220397579956,"y":329.2212618841834,"width":54,"height":20,"zIndex":33046,"fill":"#ffff00","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"Q13367","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:Q13367","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"fd96e":{"id":"fd96e","x":8.72850122850059,"y":9.114250614250409,"width":17.5,"height":16.5,"zIndex":33114,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"e59fe"},"c4461":{"textContent":"STRUCTURAL CHANGE\nOF CHROMATIN","id":"c4461","x":235,"y":91.04481792717093,"width":160,"height":29.955182072829075,"zIndex":33024,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"f4c60":{"textContent":"Apoptosis","id":"f4c60","wpType":"Pathway","x":691.6652894198527,"y":745.3634065416168,"width":76.30077787381167,"height":20,"zIndex":33047,"fontWeight":"bold","fontSize":12,"verticalAlign":"middle","drawAs":"none","stroke":"#003399","textAlign":"center","fill":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"WikiPathways","xrefIdentifier":"WP254","type":["DataNode","SingleFreeNode","WikiPathways:WP254","Pathway"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"a2964":{"id":"a2964","x":10.417728062538345,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":33116,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"d4106"},"d5690":{"textContent":"Inactive\nDimer","id":"d5690","x":127.53268629633635,"y":199.42548942276255,"width":47,"height":20,"zIndex":33025,"fill":"transparent","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"e75f4":{"textContent":"G2/M Transition","id":"e75f4","wpType":"Pathway","citations":["publicationXrefd8e"],"x":423.9584827178014,"y":841.8252427184466,"width":100.28128336406996,"height":20.911127707244223,"zIndex":33048,"fontWeight":"bold","fontSize":12,"verticalAlign":"middle","drawAs":"none","stroke":"#003399","textAlign":"center","fill":"transparent","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"WikiPathways","xrefIdentifier":"WP1859","type":["DataNode","SingleFreeNode","WikiPathways:WP1859","Pathway"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"ed4f9":{"id":"ed4f9","x":25.703701531801244,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":33118,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"c267d"},"c5d19":{"textContent":"Cell\nSurvival","id":"c5d19","x":55.14060051763636,"y":250.8869027066405,"width":65.40834845735023,"height":28.33313468341603,"zIndex":33026,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"aa362":{"textContent":"CDK1","id":"aa362","wpType":"GeneProduct","citations":["publicationXrefeb2","publicationXrefd93","publicationXrefae2","publicationXrefecc","publicationXreff9d","publicationXrefd75"],"x":116.65412876137229,"y":587.2699194627573,"width":46.898005598320516,"height":20,"zIndex":33049,"fill":"#990099","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"stroke":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000170312","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000170312","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"cc305":{"id":"cc305","x":8.72850122850059,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":33120,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"f69ac"},"c5090":{"textContent":"MRN Complex","id":"c5090","x":807.8638834473143,"y":121.31560127501768,"width":80,"height":20,"zIndex":33027,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"c6daf":{"textContent":"ATM","id":"c6daf","wpType":"GeneProduct","citations":["publicationXrefdf4","publicationXrefbe6","publicationXrefc96","publicationXrefb19","publicationXrefa3e","publicationXrefc42"],"x":8,"y":24.21833049026168,"width":38,"height":20,"zIndex":33050,"fill":"#333333","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"stroke":"#ffff00","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000149311","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000149311","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"ba74c"},"b874b":{"id":"b874b","x":312.6779979017549,"y":548.3578099517326,"width":17.5,"height":16.5,"zIndex":33122,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape"},"aae5f":{"textContent":"P","id":"aae5f","x":8,"y":8,"width":19,"height":20,"zIndex":33029,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"be8f0"},"ce4b5":{"textContent":"H2AX","id":"ce4b5","wpType":"Protein","citations":["publicationXrefb9e","publicationXrefb5d","publicationXrefa8b","publicationXrefea3","publicationXrefb2b","publicationXrefb59"],"x":826,"y":298.0126960418222,"width":54.53323375653474,"height":25.882001493652048,"zIndex":33051,"fill":"#66ccff","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","stroke":"#333333","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"P16104","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:P16104","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"cee07":{"id":"cee07","x":8.72850122850059,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":33124,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"bbcee"},"c7b53":{"textContent":"Cell\nSurvival","id":"c7b53","x":982.6737759402556,"y":664.5089928619872,"width":66.81547503657734,"height":28.316037214298376,"zIndex":33031,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"c46cc":{"textContent":"RAD9A","id":"c46cc","wpType":"GeneProduct","citations":["publicationXrefad2","publicationXrefeaa"],"x":8,"y":23.643005086117256,"width":54.52147314523285,"height":27.631138288277793,"zIndex":33052,"fill":"#990099","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"HexagonPathVisio","stroke":"#ffff00","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000172613","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000172613","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"c267d"},"b9638":{"id":"b9638","x":11.2454677838316,"y":9.36961322916386,"width":17.5,"height":16.5,"zIndex":33126,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"cb081"},"dc7c0":{"textContent":"Synaptic Vesicle\nTransport","id":"dc7c0","x":936.0582000902521,"y":391.919229312839,"width":103.05438269120538,"height":49.41189651497551,"zIndex":33032,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"afc0e":{"textContent":"PIDD","id":"afc0e","wpType":"GeneProduct","citations":["publicationXrefa7e","publicationXrefc3d","publicationXrefbd5","publicationXrefde4","publicationXreffa9","publicationXrefbf0"],"x":10.98822503886322,"y":25.95432585753838,"width":48.6430423509075,"height":20,"zIndex":33053,"fill":"#ff0033","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"stroke":"#ffffff","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000177595","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000177595","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"e36e7"},"fdd73":{"id":"fdd73","x":8.72850122850059,"y":9.114250614250295,"width":17.5,"height":16.5,"zIndex":33128,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"aa169"},"dca06":{"textContent":"Cell\nSurvival","id":"dca06","x":481.04362897188366,"y":740.1798679480507,"width":65.40834845735023,"height":28.33313468341603,"zIndex":33096,"fill":"transparent","fontWeight":"bold","fontSize":12,"verticalAlign":"middle","stroke":"#003399","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label"},"c079d":{"textContent":"RAD51","id":"c079d","wpType":"GeneProduct","citations":["publicationXrefb20","publicationXrefb90","publicationXrefd72","publicationXrefbad","publicationXrefef8","publicationXrefe91","publicationXrefcb9","publicationXrefba9","publicationXrefeeb"],"x":9.283049470770948,"y":18.59530607419856,"width":49.31853069831371,"height":34.78864824495884,"zIndex":33054,"fill":"#ff9933","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"left","drawAs":"PentagonPathVisio","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Ensembl","xrefIdentifier":"ENSG00000051180","type":["DataNode","SingleFreeNode","Ensembl:ENSG00000051180","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"f69ac"},"e5e60":{"id":"e5e60","x":8.72850122850059,"y":9.114250614250523,"width":17.5,"height":16.5,"zIndex":33130,"fill":"#ffff00","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","rotation":0,"textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","fontWeight":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Shape","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Shape","isPartOf":"f5fb5"},"c3821":{"textContent":"P","id":"c3821","x":8,"y":8,"width":19,"height":20,"zIndex":33115,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"e59fe"},"c332a":{"textContent":"TLK1","id":"c332a","wpType":"Protein","citations":["publicationXrefe88","publicationXrefd91","publicationXrefcd0"],"x":487.66426017252275,"y":544.9291270527235,"width":47,"height":20,"zIndex":33055,"fill":"#999999","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"drawAs":"rect","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"Q9UKI8","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:Q9UKI8","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"d3a66":{"textContent":"P","id":"d3a66","x":9.6892268340373,"y":8,"width":19,"height":20,"zIndex":33117,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"d4106"},"a92fb":{"textContent":"CDC2","id":"a92fb","wpType":"GeneProduct","citations":["publicationXrefd78","publicationXrefb3c","publicationXrefa88","publicationXrefe3b","publicationXrefc31"],"x":419.51626654135725,"y":724.3175550958226,"width":50,"height":20,"zIndex":33056,"fill":"#339900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"rect","rx":15,"ry":15,"stroke":"#ffff00","textAlign":"center","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Entrez Gene","xrefIdentifier":"983","type":["DataNode","SingleFreeNode","Entrez Gene:983","GeneProduct"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode"},"e116a":{"textContent":"P","id":"e116a","x":24.975200303300653,"y":8,"width":19,"height":20,"zIndex":33119,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"c267d"},"ef6e7":{"textContent":"IKBA","id":"ef6e7","wpType":"Protein","citations":["publicationXrefcab","publicationXrefa61"],"x":8,"y":25.259116632631503,"width":46,"height":20,"zIndex":33057,"fill":"#cc9900","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","drawAs":"Ellipse","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":1,"lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"xrefDataSource":"Uniprot-TrEMBL","xrefIdentifier":"P25963","type":["DataNode","SingleFreeNode","Uniprot-TrEMBL:P25963","Protein"],"kaavioType":"SingleFreeNode","gpmlElementName":"DataNode","isPartOf":"af4e7"},"e3091":{"textContent":"P","id":"e3091","x":8,"y":8,"width":19,"height":20,"zIndex":33121,"fill":"transparent","fontWeight":"bold","fontSize":10,"verticalAlign":"middle","textAlign":"center","stroke":"#000000","textDecoration":"none","fontFamily":"Arial","fontStyle":"normal","strokeWidth":0,"drawAs":"none","lineHeight":1.1,"overflow":"hidden","textOverflow":"clip","whiteSpace":"pre","padding":8,"type":["Label","SingleFreeNode"],"kaavioType":"SingleFreeNode","gpmlElementName":"Label","isPartOf":"f69ac"},"b1ae8":{"textContent":"RIP1","id":"b1ae8","wpType":"GeneProduct","c