enrichr-mcp-server/build/library_descriptions.js

MCP Server for Enrichr gene set enrichment analysis with multi-library support

/**
 * This file contains descriptions for various Enrichr libraries.
 * The descriptions are used to dynamically populate the tool's help text,
 * giving the language model better context for choosing the right library.
 *
 * Source: https://maayanlab.cloud/Enrichr/#libraries
 */
export const libraryDescriptions = {
    // Transcription
    "ChEA_2022": "ChIP-seq experiments from GEO, ENCODE, and publications identifying transcription factor-gene interactions from human and mouse.",
    "ChEA_2016": "ChIP-seq experiments identifying transcription factor targets from published studies and databases (2016 version).",
    "ChEA_2013": "ChIP-seq experiments for transcription factor binding sites from published ChIP-chip, ChIP-seq, and ChIP-PET studies.",
    "ENCODE_TF_ChIP-seq_2015": "Transcription factor targets from ENCODE consortium ChIP-seq experiments across multiple cell lines.",
    "ENCODE_TF_ChIP-seq_2014": "ENCODE project transcription factor ChIP-seq data from various human cell types (2014 release).",
    "ENCODE_Histone_Modifications_2015": "Histone modification profiles from ENCODE ChIP-seq experiments indicating chromatin states.",
    "ENCODE_Histone_Modifications_2013": "ENCODE histone marks including H3K4me1, H3K4me3, H3K27ac, H3K27me3, and others across cell types.",
    "Transcription_Factor_PPIs": "Protein-protein interactions between transcription factors from various databases and studies.",
    "TRANSFAC_and_JASPAR_PWMs": "Transcription factor binding motifs from TRANSFAC and JASPAR position weight matrices.",
    "Genome_Browser_PWMs": "Position weight matrices for transcription factor binding sites from UCSC Genome Browser.",
    "MotifMap": "Predicted transcription factor binding sites across the human genome using PWM scanning.",
    "ENCODE_and_ChEA_Consensus_TFs_from_ChIP-X": "Consensus transcription factor targets combining ENCODE and ChEA ChIP experiments.",
    "TF_Perturbations_Followed_by_Expression": "Gene expression changes following transcription factor perturbations from GEO studies.",
    "TF-LOF_Expression_from_GEO": "Gene expression signatures from transcription factor loss-of-function experiments in GEO.",
    "PPI_Hub_Proteins": "Highly connected hub proteins from protein-protein interaction networks.",
    "CORUM": "Protein complexes from the comprehensive resource of mammalian protein complexes database.",
    // Pathways
    "KEGG_2021_Human": "Metabolic and signaling pathways from Kyoto Encyclopedia of Genes and Genomes for human.",
    "KEGG_2019_Human": "KEGG metabolic and signaling pathways database for human (2019 version).",
    "KEGG_2019_Mouse": "KEGG metabolic and signaling pathways database for mouse (2019 version).",
    "KEGG_2016": "KEGG pathways including metabolism, genetic information, environmental information, and cellular processes (2016).",
    "KEGG_2015": "KEGG pathway database covering metabolism, diseases, and drug development (2015 version).",
    "KEGG_2013": "KEGG pathways for metabolism, genetic information processing, and human diseases (2013 version).",
    "Reactome_2022": "Curated and peer-reviewed pathways from Reactome covering signaling, metabolism, gene expression, and disease.",
    "Reactome_2016": "Reactome biological pathways including metabolic, signaling, and regulatory pathways (2016 version).",
    "Reactome_2013": "Reactome pathway database with reactions, complexes, and biological processes (2013 version).",
    "WikiPathways_2023_Human": "Community-curated biological pathways from WikiPathways for human biology and disease.",
    "WikiPathways_2021_Human": "WikiPathways community-curated pathway collection for human (2021 version).",
    "WikiPathways_2019_Human": "Human biological pathways from WikiPathways collaborative platform (2019 version).",
    "WikiPathways_2019_Mouse": "Mouse biological pathways from WikiPathways collaborative platform (2019 version).",
    "WikiPathways_2016": "Community-edited biological pathways covering metabolic, signaling, and disease pathways (2016).",
    "WikiPathways_2015": "WikiPathways collection of biological pathways created by the research community (2015).",
    "WikiPathways_2013": "Community-curated pathway diagrams from WikiPathways (2013 version).",
    "BioCarta_2016": "Professionally illustrated signaling and metabolic pathways from BioCarta (2016 version).",
    "BioCarta_2015": "BioCarta pathway diagrams focusing on signaling cascades and molecular interactions (2015).",
    "BioCarta_2013": "BioCarta's collection of biological pathways with detailed molecular interactions (2013).",
    "HumanCyc_2016": "Metabolic pathways and genome database from HumanCyc for Homo sapiens.",
    "HumanCyc_2015": "HumanCyc encyclopedia of human metabolic pathways and the human genome (2015).",
    "NCI-Nature_2016": "Curated signaling pathways from National Cancer Institute and Nature Publishing Group.",
    "NCI-Nature_2015": "NCI-Nature Pathway Interaction Database of biomolecular interactions and cellular processes (2015).",
    "Panther_2016": "Protein families, functions, and pathways from PANTHER classification system.",
    "Panther_2015": "PANTHER pathway database including signaling, metabolic, and disease pathways (2015).",
    "MSigDB_Hallmark_2020": "Hallmark gene sets representing well-defined biological states and processes from MSigDB.",
    "BioPlanet_2019": "Integrated pathway database combining KEGG, Reactome, WikiPathways, and other sources.",
    "NURSA_Human_Endogenous_Complexome": "Nuclear receptor signaling complexes and coregulator interactions from NURSA.",
    "hu.MAP": "Human protein complexes derived from over 9,000 mass spectrometry experiments.",
    // Ontologies
    "GO_Biological_Process_2025": "Gene Ontology terms describing biological objectives accomplished by gene products.",
    "GO_Biological_Process_2023": "GO terms for biological processes like metabolism, signaling, and development (2023).",
    "GO_Biological_Process_2021": "Gene Ontology biological process annotations describing gene product activities (2021).",
    "GO_Biological_Process_2018": "GO biological process terms covering cellular and physiological processes (2018).",
    "GO_Biological_Process_2017": "Gene Ontology biological processes from cellular to organism level (2017).",
    "GO_Biological_Process_2015": "GO BP terms describing biological programs accomplished by multiple molecular activities (2015).",
    "GO_Biological_Process_2013": "Gene Ontology terms for biological processes and pathways (2013).",
    "GO_Molecular_Function_2025": "Gene Ontology terms describing molecular-level activities performed by gene products.",
    "GO_Molecular_Function_2023": "GO terms for molecular functions like binding, catalysis, and transporter activity (2023).",
    "GO_Molecular_Function_2021": "Gene Ontology molecular function annotations for biochemical activities (2021).",
    "GO_Molecular_Function_2018": "GO molecular function terms describing enzymatic and binding activities (2018).",
    "GO_Molecular_Function_2017": "Gene Ontology molecular functions including catalytic and binding activities (2017).",
    "GO_Molecular_Function_2015": "GO MF terms describing activities at the molecular level (2015).",
    "GO_Molecular_Function_2013": "Gene Ontology molecular function annotations (2013).",
    "GO_Cellular_Component_2025": "Gene Ontology terms describing locations of gene products relative to cellular structures.",
    "GO_Cellular_Component_2023": "GO terms for cellular components like organelles, membranes, and protein complexes (2023).",
    "GO_Cellular_Component_2021": "Gene Ontology cellular component annotations for subcellular localizations (2021).",
    "GO_Cellular_Component_2018": "GO cellular component terms describing parts of cells and extracellular environments (2018).",
    "GO_Cellular_Component_2017": "Gene Ontology cellular components including anatomical structures (2017).",
    "GO_Cellular_Component_2015": "GO CC terms describing locations relative to cellular structures (2015).",
    "GO_Cellular_Component_2013": "Gene Ontology cellular component locations (2013).",
    "Human_Phenotype_Ontology": "Standardized vocabulary of phenotypic abnormalities associated with human diseases.",
    "MGI_Mammalian_Phenotype_2021": "Mouse Genome Informatics mammalian phenotype ontology for model organism phenotypes.",
    "MGI_Mammalian_Phenotype_2017": "MGI phenotype ontology describing mouse phenotypes from genetic modifications (2017).",
    "MGI_Mammalian_Phenotype_2013": "Mouse phenotype ontology from Mouse Genome Informatics (2013).",
    "MGI_Mammalian_Phenotype_Level_3": "High-level mammalian phenotype categories from MGI ontology.",
    "MGI_Mammalian_Phenotype_Level_4": "Detailed mammalian phenotype terms from MGI ontology level 4.",
    "Human_Gene_Atlas": "Gene expression across normal human tissues from microarray experiments.",
    "Anatomy_AutoRIF": "Anatomical terms automatically extracted from gene-publication associations.",
    "Anatomy_AutoRIF_Predicted_Z-score": "Predicted anatomical associations using AutoRIF with statistical scoring.",
    "Jensen_TISSUES": "Tissue and cell type expression from text mining, proteomics, and manually curated sources.",
    "Jensen_COMPARTMENTS": "Subcellular localization from text mining, predictions, and curated databases.",
    "Jensen_DISEASES": "Disease-gene associations from text mining, cancer mutation data, and GWAS.",
    "ARCHS4_Tissues": "Tissue-specific gene expression signatures from ARCHS4 RNA-seq compendium.",
    "ARCHS4_Cell-lines": "Cell line-specific gene expression signatures from ARCHS4 RNA-seq database.",
    "Uberon_Cross_Species_Phenotype_Ontology": "Cross-species anatomical structure ontology linking phenotypes across organisms.",
    // Diseases/Drugs  
    "GWAS_Catalog_2023": "Genome-wide association study results from NHGRI-EBI GWAS Catalog linking genes to traits.",
    "GWAS_Catalog_2019": "Curated GWAS associations between genetic variants and diseases/traits (2019).",
    "UK_Biobank_GWAS_v1": "Genome-wide associations from UK Biobank cohort for complex traits and diseases.",
    "ClinVar_2019": "Pathogenic and benign genetic variants from ClinVar database of clinical significance.",
    "PheWeb_2019": "Phenome-wide association results aggregating GWAS data across multiple traits.",
    "DisGeNET": "Curated gene-disease associations from expert databases, GWAS, and literature.",
    "PhenGenI_Association_2021": "Phenotype-genotype associations integrating NHGRI GWAS Catalog and other sources.",
    "Orphanet_Augmented_2021": "Rare disease-gene associations from Orphanet with additional literature curation.",
    "Rare_Diseases_AutoRIF_Gene_Lists": "Rare disease gene sets extracted automatically from biomedical literature.",
    "Rare_Diseases_AutoRIF_ARCHS4_Predictions": "Predicted rare disease associations using AutoRIF and ARCHS4 expression data.",
    "Rare_Diseases_GeneRIF_Gene_Lists": "Manually curated rare disease gene sets from GeneRIF annotations.",
    "Rare_Diseases_GeneRIF_ARCHS4_Predictions": "Rare disease predictions combining GeneRIF curation with ARCHS4 expression.",
    "DrugBank_2022": "Drug targets from DrugBank including approved drugs and experimental compounds.",
    "DrugBank_2018": "DrugBank database of drug targets for FDA-approved and experimental drugs (2018).",
    "DSigDB": "Drug-induced gene expression signatures from public gene expression data.",
    "Drug_Perturbations_from_GEO_2014": "Gene expression signatures from drug treatment experiments in GEO (2014).",
    "Drug_Perturbations_from_GEO_down": "Genes downregulated by drug treatments from GEO experiments.",
    "Drug_Perturbations_from_GEO_up": "Genes upregulated by drug treatments from GEO experiments.",
    "LINCS_L1000_Chem_Pert_down": "Genes downregulated by chemical perturbations from LINCS L1000 dataset.",
    "LINCS_L1000_Chem_Pert_up": "Genes upregulated by chemical perturbations from LINCS L1000 dataset.",
    "LINCS_L1000_Ligand_Perturbations_down": "Downregulated genes from ligand treatments in LINCS L1000.",
    "LINCS_L1000_Ligand_Perturbations_up": "Upregulated genes from ligand treatments in LINCS L1000.",
    "Drug_Matrix": "Toxicogenomics data from DrugMatrix showing drug effects on gene expression.",
    "HMS_LINCS_KinomeScan": "Kinase inhibitor selectivity profiles from Harvard Medical School LINCS.",
    "Proteomics_Drug_Atlas_2023": "Drug-protein interactions from proteomics studies of drug treatments.",
    "Virus_Perturbations_from_GEO_down": "Genes downregulated during viral infections from GEO datasets.",
    "Virus_Perturbations_from_GEO_up": "Genes upregulated during viral infections from GEO datasets.",
    "VirusMINT": "Virus-host protein interactions from the VirusMINT database.",
    "Disease_Perturbations_from_GEO_down": "Genes downregulated in disease states from GEO expression studies.",
    "Disease_Perturbations_from_GEO_up": "Genes upregulated in disease states from GEO expression studies.",
    "Disease_Signatures_from_GEO_down_2014": "Disease gene expression signatures showing downregulation from GEO (2014).",
    "Disease_Signatures_from_GEO_up_2014": "Disease gene expression signatures showing upregulation from GEO (2014).",
    "Disease_Signatures_from_GEO_Manual_down": "Manually curated disease signatures with downregulated genes from GEO.",
    "Disease_Signatures_from_GEO_Manual_up": "Manually curated disease signatures with upregulated genes from GEO.",
    "COVID-19_Related_Gene_Sets": "Gene sets related to SARS-CoV-2 infection and COVID-19 pathogenesis.",
    "COVID-19_Related_Gene_Sets_2021": "Updated COVID-19 gene sets including host response and viral interactions (2021).",
    "HDSigDB_Human_2021": "Human disease signatures database with curated disease-gene associations.",
    "HDSigDB_Mouse_2021": "Mouse disease signatures database for model organism disease studies.",
    "OMIM_Disease": "Genetic diseases and associated genes from Online Mendelian Inheritance in Man.",
    "OMIM_Expanded": "Expanded OMIM disease-gene associations including complex traits.",
    "DepMap_WG_CRISPR_Screens_Broad_CellLines_2019": "Essential genes from genome-wide CRISPR screens across cancer cell lines.",
    "DepMap_WG_CRISPR_Screens_Sanger_CellLines_2019": "Cancer cell line dependencies from Sanger Institute CRISPR screens.",
    "Achilles_fitness_decrease": "Genes whose knockout decreases cell fitness from Project Achilles.",
    "Achilles_fitness_increase": "Genes whose knockout increases cell fitness from Project Achilles.",
    "GeneSigDB": "Curated gene signatures from publications for diseases, drugs, and phenotypes.",
    "GWASdb_2023": "Comprehensive GWAS database integrating results from multiple studies.",
    "MAGMA_Drugs_and_Diseases": "Drug and disease associations from MAGMA gene-set analysis of GWAS.",
    "MAGNET_2023": "Cell type-specific gene signatures from single-cell RNA-seq meta-analysis.",
    "GeDiPNet_2023": "Gene-disease-phenotype network integrating multiple data sources.",
    // Cell Types
    "GTEx_Tissue_Expression_Down": "Genes with lower expression in specific tissues from GTEx project.",
    "GTEx_Tissue_Expression_Up": "Genes with higher expression in specific tissues from GTEx project.",
    "GTEx_Tissue_Sample_Gene_Expression_Profiles_down": "Tissue-specific low expression profiles from GTEx RNA-seq samples.",
    "GTEx_Tissue_Sample_Gene_Expression_Profiles_up": "Tissue-specific high expression profiles from GTEx RNA-seq samples.",
    "GTEx_Aging_Signatures_2021": "Age-related gene expression changes across tissues from GTEx.",
    "Allen_Brain_Atlas_10x_scRNA_2021": "Cell type markers from Allen Brain Atlas single-cell RNA-seq at 10x resolution.",
    "Allen_Brain_Atlas_down": "Genes with low expression in brain regions from Allen Brain Atlas.",
    "Allen_Brain_Atlas_up": "Genes with high expression in brain regions from Allen Brain Atlas.",
    "Tabula_Muris": "Cell type markers from Tabula Muris single-cell atlas of mouse organs.",
    "Tabula_Sapiens": "Human cell type markers from Tabula Sapiens single-cell reference atlas.",
    "Azimuth_Cell_Types_2021": "Cell type signatures from Azimuth reference mapping of single-cell data.",
    "Azimuth_Cell_Types_Top5_Markers": "Top 5 marker genes for each cell type from Azimuth references.",
    "CellMarker_2024": "Manually curated cell type markers from CellMarker database for human and mouse.",
    "CellMarker_Augmented_2021": "Expanded cell type markers combining CellMarker with literature mining.",
    "PanglaoDB_Augmented_2021": "Cell type markers from PanglaoDB with additional curation and validation.",
    "Descartes_Cell_Types_and_Tissue_2021": "Cell type and tissue signatures from Descartes human cell atlas.",
    "HuBMAP_ASCTplusB_augmented_2022": "Cell types from Human BioMolecular Atlas Program with anatomical structures.",
    "FANTOM6_lncRNA_KD_DEGs": "Differentially expressed genes from FANTOM6 lncRNA knockdown experiments.",
    "CCLE_Proteomics_2020": "Protein expression profiles across cancer cell lines from CCLE.",
    "ProteomicsDB_2020": "Human proteome expression across tissues and cell types from ProteomicsDB.",
    "HPA_Protein_Atlas_2023": "Protein expression across human tissues from Human Protein Atlas.",
    // MicroRNAs
    "TargetScan_microRNA_2017": "Predicted microRNA targets based on seed sequence complementarity from TargetScan.",
    "miRTarBase_2017": "Experimentally validated microRNA-target interactions from miRTarBase.",
    "miRTarBase_2022": "Updated experimentally validated microRNA targets from miRTarBase database.",
    "MiRDB_2019": "MicroRNA target predictions using machine learning from MiRDB.",
    // Transcription/Epigenetics
    "Epigenomics_Roadmap_HM_ChIP-seq": "Histone modification profiles from NIH Roadmap Epigenomics Project.",
    "ENCODE_Chromatin_Accessibility_2023": "Open chromatin regions from ENCODE DNase-seq and ATAC-seq experiments.",
    "ReMap_2022": "Transcription factor and chromatin regulator binding sites from curated ChIP-seq.",
    "ChIP_Atlas_2023": "Integrated transcription factor binding profiles from public ChIP-seq data.",
    // Kinases  
    "KEA_2015": "Kinase enrichment analysis from known kinase-substrate interactions (2015).",
    "KEA_2013": "Kinase-substrate relationships from phosphorylation databases (2013).",
    "Kinase_Perturbations_from_GEO_down": "Genes downregulated by kinase perturbations from GEO.",
    "Kinase_Perturbations_from_GEO_up": "Genes upregulated by kinase perturbations from GEO.",
    "LINCS_L1000_Kinase_Perturbations_down": "Downregulated genes from kinase inhibitor treatments in LINCS.",
    "LINCS_L1000_Kinase_Perturbations_up": "Upregulated genes from kinase inhibitor treatments in LINCS.",
    "PhosphoSitePlus_2023": "Phosphorylation sites and kinase-substrate relationships from PhosphoSitePlus.",
    "iPTMnet_2023": "Integrated post-translational modification network including phosphorylation.",
    "PTMsigDB_2023": "PTM signatures database linking modifications to biological processes.",
    // Gene Perturbations
    "LINCS_L1000_CRISPR_KO_Consensus_Sigs": "Consensus gene signatures from CRISPR knockouts in LINCS L1000.",
    "CRISPR_GenomeWide_2023": "Genome-wide CRISPR screen results across multiple studies and cell types.",
    "L1000_Kinase_and_GPCR_Perturbations_down": "Downregulated genes from kinase and GPCR perturbations in L1000.",
    "L1000_Kinase_and_GPCR_Perturbations_up": "Upregulated genes from kinase and GPCR perturbations in L1000.",
    "LINCS_L1000_shRNA_Consensus_Sigs": "Consensus signatures from shRNA knockdowns in LINCS L1000.",
    "TG_GATES_2020": "Toxicogenomics gene expression from TG-GATES database.",
    "ORCAtlas_2023": "Over-representation analysis results from curated gene set collections.",
    // Metabolomics
    "HMDB_Metabolites": "Metabolite-associated genes from Human Metabolome Database.",
    "Metabolomics_Workbench_2023": "Metabolite-gene associations from Metabolomics Workbench studies.",
    "SMPDB_2023": "Small molecule pathways from SMPDB linking metabolites to genes.",
    // Aging
    "Aging_Perturbations_from_GEO_down": "Genes downregulated during aging from GEO studies.",
    "Aging_Perturbations_from_GEO_up": "Genes upregulated during aging from GEO studies.",
    "GenAge_2023": "Aging-related genes from the GenAge database of aging research.",
    "Longevity_Map_2023": "Genes associated with longevity from human and model organism studies.",
    // Protein Families
    "InterPro_Domains_2019": "Protein domain families from InterPro integrated database.",
    "Pfam_Domains_2019": "Protein families based on Pfam domain annotations.",
    "UniProt_Keywords_2023": "Functional keywords and features from UniProt protein database.",
    "Homologene": "Homologous gene groups across species from NCBI HomoloGene.",
    // Computational Predictions
    "Enrichr_Users_Contributed_Lists_2020": "Community-contributed gene sets from Enrichr users.",
    "Enrichr_Consensus_Top_100": "Top 100 enriched terms across all Enrichr analyses.",
    "Enrichr_Libraries_Most_Popular_Genes": "Most frequently appearing genes across Enrichr libraries.",
    "Enrichr_Submissions_TF-Gene_Coocurrence": "Transcription factor-gene co-occurrence from user submissions.",
    "ARCHS4_Kinase_Coexp": "Kinase co-expression modules from ARCHS4 RNA-seq compendium.",
    "ARCHS4_TF_Coexp": "Transcription factor co-expression modules from ARCHS4.",
    "ARCHS4_IDG_Coexp": "Illuminating the Druggable Genome target co-expression from ARCHS4.",
    "GeneRIF/ARCHS4_Human_Top_Predicted_Transcription_Factors": "Predicted TF regulators combining GeneRIF with ARCHS4 co-expression.",
    "GeneRIF/ARCHS4_Mouse_Top_Predicted_Transcription_Factors": "Mouse predicted TF regulators from GeneRIF and ARCHS4.",
    // Literature-based
    "Rummagene_kinases": "Kinase-associated genes extracted from biomedical literature by Rummagene.",
    "Rummagene_transcription_factors": "Transcription factor associations from Rummagene literature mining.",
    "Rummagene_signatures": "Gene signatures extracted from figures in biomedical publications.",
    "AutoRIF": "Automated gene annotations extracted from PubMed abstracts using RIF.",
    "GeneRIF": "Gene Reference Into Function - curated gene function descriptions from literature.",
    "GO_Biological_Process_AutoRIF": "GO biological processes extracted automatically from literature.",
    "GO_Molecular_Function_AutoRIF": "GO molecular functions extracted automatically from literature.",
    "GO_Cellular_Component_AutoRIF": "GO cellular components extracted automatically from literature.",
    // Cancer-specific
    "COSMIC_Cancer_Gene_Census": "Cancer driver genes from COSMIC Cancer Gene Census.",
    "TCGA_Coexp_2023": "Gene co-expression modules from The Cancer Genome Atlas.",
    "TCGA_Mutations_2023": "Frequently mutated genes in cancers from TCGA mutation data.",
    "OncoKB_2023": "Precision oncology knowledge base with cancer gene annotations.",
    "Cancer_Cell_Line_Encyclopedia": "Gene dependencies and expression from cancer cell lines.",
    "GDSC_2023": "Drug sensitivity genes from Genomics of Drug Sensitivity in Cancer.",
    // Single Cell
    "Human_Cell_Landscape": "Cell type markers from Human Cell Landscape single-cell project.",
    "Mouse_Cell_Atlas": "Mouse cell type signatures from comprehensive single-cell atlas.",
    "scRNAseq_Datasets_2023": "Cell type markers aggregated from multiple scRNA-seq studies.",
    "SingleCellSignatures_2023": "Curated single-cell signatures for cell types and states.",
    // Chromosome Location
    "Chromosome_Location": "Genes organized by their chromosomal location in the human genome.",
    "Chromosome_Location_hg19": "Gene locations based on human genome assembly hg19.",
    // Protein-Protein Interactions
    "STRING_Interactions_2023": "Protein interactions from STRING database including experimental and predicted.",
    "BioGRID_2023": "Protein and genetic interactions from BioGRID database.",
    "IntAct_2023": "Molecular interactions from IntAct database with experimental evidence.",
    "MINT_2023": "Molecular interactions from MINT focusing on experimentally verified interactions.",
    // Structural
    "PDB_Structural_Annotations": "Gene annotations based on 3D protein structures from PDB.",
    "AlphaFold_2023": "Predicted protein structures and functional annotations from AlphaFold.",
    // Immunology
    "ImmuneSigDB": "Immunological signatures for cell states and perturbations.",
    "ImmPort_2023": "Immunology gene sets from ImmPort immunology database.",
    "Immunological_Signatures_MSigDB": "C7 immunological signatures collection from MSigDB.",
    // Development
    "ESCAPE": "Embryonic stem cell signatures from pluripotency studies.",
    "Developmental_Signatures_2023": "Gene signatures from developmental biology studies.",
    "Embryonic_Stem_Cell_Atlas_from_Pluripotency_Evidence": "ES cell-related genes from multiple evidence sources.",
    // Regulatory
    "JASPAR_2022": "Transcription factor binding profiles from JASPAR database.",
    "HOCOMOCO_v11": "Human and mouse transcription factor binding models.",
    "SwissRegulon_2023": "Transcription factor targets from SwissRegulon predictions.",
    "Cistrome_2023": "Chromatin regulator and TF targets from Cistrome Data Browser.",
    // Other Resources
    "MSigDB_Computational": "Computationally derived gene sets from MSigDB including co-expression.",
    "MSigDB_Curated": "Expert-curated gene sets from MSigDB canonical pathways and literature.",
    "SynGO_2022": "Synaptic gene ontology for genes involved in synaptic processes.",
    "SysMyo_2023": "Muscle system gene sets for muscle biology and diseases.",
    "FlyBase_2023": "Drosophila gene sets for cross-species analysis.",
    "WormBase_2023": "C. elegans gene sets for model organism comparisons.",
    "HGNC_Gene_Families": "Gene families classified by HUGO Gene Nomenclature Committee.",
    "NURBS_2023": "Nuclear receptor binding sites from ChIP experiments.",
    "ToppGene_2023": "Training gene sets from ToppGene for gene prioritization.",
    "Bioplanet_2019": "Integrated pathway gene sets combining multiple databases.",
    "GTEx_eQTL": "Expression quantitative trait loci from GTEx linking variants to gene expression.",
    "clinGen_2023": "Clinical validity of gene-disease relationships from ClinGen.",
    "Alliance_Genome_2023": "Cross-species gene function from Alliance of Genome Resources.",
    "IDG_Drug_Targets_2023": "Illuminating the Druggable Genome understudied drug targets.",
    "Ligand_Receptor_Pairs_2023": "Curated ligand-receptor interaction pairs for cell communication.",
    "IMPC_2023": "Mouse phenotypes from International Mouse Phenotyping Consortium.",
    "KOMP2_2023": "Knockout Mouse Phenotyping Program gene-phenotype associations.",
    "MGI_2023": "Mouse Genome Informatics gene annotations and phenotypes.",
    "DEPOD_2023": "Human dephosphorylation database with phosphatase-substrate pairs.",
    "dbGAP_2023": "Gene associations from database of Genotypes and Phenotypes.",
    "UK_Biobank_2023": "Gene associations from UK Biobank genetic analyses.",
    "FinnGen_2023": "Finnish genetics study gene-disease associations.",
    "Open_Targets_2023": "Drug target validation from Open Targets Platform.",
    "PharmGKB_2023": "Pharmacogenomics knowledge for drug-gene interactions.",
    "STITCH_2023": "Chemical-protein interactions from STITCH database.",
    "L1000_Connectivity_Map_2023": "Drug and genetic perturbation signatures from updated CMap.",
    "CMAP_2023": "Connectivity Map signatures linking drugs, genes, and diseases."
};