@medplum/fhirtypes/dist/MedicationKnowledge.d.ts

Medplum FHIR Type Definitions

/*
 * This is a generated file
 * Do not edit manually.
 */

import { CodeableConcept } from './CodeableConcept';
import { DetectedIssue } from './DetectedIssue';
import { DocumentReference } from './DocumentReference';
import { Dosage } from './Dosage';
import { Duration } from './Duration';
import { Extension } from './Extension';
import { Media } from './Media';
import { Medication } from './Medication';
import { Meta } from './Meta';
import { Money } from './Money';
import { Narrative } from './Narrative';
import { ObservationDefinition } from './ObservationDefinition';
import { Organization } from './Organization';
import { Quantity } from './Quantity';
import { Ratio } from './Ratio';
import { Reference } from './Reference';
import { Resource } from './Resource';
import { Substance } from './Substance';

/**
 * Information about a medication that is used to support knowledge.
 */
export interface MedicationKnowledge {

  /**
   * This is a MedicationKnowledge resource
   */
  readonly resourceType: 'MedicationKnowledge';

  /**
   * The logical id of the resource, as used in the URL for the resource.
   * Once assigned, this value never changes.
   */
  id?: string;

  /**
   * The metadata about the resource. This is content that is maintained by
   * the infrastructure. Changes to the content might not always be
   * associated with version changes to the resource.
   */
  meta?: Meta;

  /**
   * A reference to a set of rules that were followed when the resource was
   * constructed, and which must be understood when processing the content.
   * Often, this is a reference to an implementation guide that defines the
   * special rules along with other profiles etc.
   */
  implicitRules?: string;

  /**
   * The base language in which the resource is written.
   */
  language?: string;

  /**
   * A human-readable narrative that contains a summary of the resource and
   * can be used to represent the content of the resource to a human. The
   * narrative need not encode all the structured data, but is required to
   * contain sufficient detail to make it "clinically safe" for a human to
   * just read the narrative. Resource definitions may define what content
   * should be represented in the narrative to ensure clinical safety.
   */
  text?: Narrative;

  /**
   * These resources do not have an independent existence apart from the
   * resource that contains them - they cannot be identified independently,
   * and nor can they have their own independent transaction scope.
   */
  contained?: Resource[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the resource. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the resource and that modifies the
   * understanding of the element that contains it and/or the understanding
   * of the containing element's descendants. Usually modifier elements
   * provide negation or qualification. To make the use of extensions safe
   * and manageable, there is a strict set of governance applied to the
   * definition and use of extensions. Though any implementer is allowed to
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension. Applications processing a
   * resource are required to check for modifier extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * A code that specifies this medication, or a textual description if no
   * code is available. Usage note: This could be a standard medication
   * code such as a code from RxNorm, SNOMED CT, IDMP etc. It could also be
   * a national or local formulary code, optionally with translations to
   * other code systems.
   */
  code?: CodeableConcept;

  /**
   * A code to indicate if the medication is in active use.  The status
   * refers to the validity about the information of the medication and not
   * to its medicinal properties.
   */
  status?: 'active' | 'inactive' | 'entered-in-error';

  /**
   * Describes the details of the manufacturer of the medication product.
   * This is not intended to represent the distributor of a medication
   * product.
   */
  manufacturer?: Reference<Organization>;

  /**
   * Describes the form of the item.  Powder; tablets; capsule.
   */
  doseForm?: CodeableConcept;

  /**
   * Specific amount of the drug in the packaged product.  For example,
   * when specifying a product that has the same strength (For example,
   * Insulin glargine 100 unit per mL solution for injection), this
   * attribute provides additional clarification of the package amount (For
   * example, 3 mL, 10mL, etc.).
   */
  amount?: Quantity;

  /**
   * Additional names for a medication, for example, the name(s) given to a
   * medication in different countries.  For example, acetaminophen and
   * paracetamol or salbutamol and albuterol.
   */
  synonym?: string[];

  /**
   * Associated or related knowledge about a medication.
   */
  relatedMedicationKnowledge?: MedicationKnowledgeRelatedMedicationKnowledge[];

  /**
   * Associated or related medications.  For example, if the medication is
   * a branded product (e.g. Crestor), this is the Therapeutic Moeity (e.g.
   * Rosuvastatin) or if this is a generic medication (e.g. Rosuvastatin),
   * this would link to a branded product (e.g. Crestor).
   */
  associatedMedication?: Reference<Medication>[];

  /**
   * Category of the medication or product (e.g. branded product,
   * therapeutic moeity, generic product, innovator product, etc.).
   */
  productType?: CodeableConcept[];

  /**
   * Associated documentation about the medication.
   */
  monograph?: MedicationKnowledgeMonograph[];

  /**
   * Identifies a particular constituent of interest in the product.
   */
  ingredient?: MedicationKnowledgeIngredient[];

  /**
   * The instructions for preparing the medication.
   */
  preparationInstruction?: string;

  /**
   * The intended or approved route of administration.
   */
  intendedRoute?: CodeableConcept[];

  /**
   * The price of the medication.
   */
  cost?: MedicationKnowledgeCost[];

  /**
   * The program under which the medication is reviewed.
   */
  monitoringProgram?: MedicationKnowledgeMonitoringProgram[];

  /**
   * Guidelines for the administration of the medication.
   */
  administrationGuidelines?: MedicationKnowledgeAdministrationGuidelines[];

  /**
   * Categorization of the medication within a formulary or classification
   * system.
   */
  medicineClassification?: MedicationKnowledgeMedicineClassification[];

  /**
   * Information that only applies to packages (not products).
   */
  packaging?: MedicationKnowledgePackaging;

  /**
   * Specifies descriptive properties of the medicine, such as color,
   * shape, imprints, etc.
   */
  drugCharacteristic?: MedicationKnowledgeDrugCharacteristic[];

  /**
   * Potential clinical issue with or between medication(s) (for example,
   * drug-drug interaction, drug-disease contraindication, drug-allergy
   * interaction, etc.).
   */
  contraindication?: Reference<DetectedIssue>[];

  /**
   * Regulatory information about a medication.
   */
  regulatory?: MedicationKnowledgeRegulatory[];

  /**
   * The time course of drug absorption, distribution, metabolism and
   * excretion of a medication from the body.
   */
  kinetics?: MedicationKnowledgeKinetics[];
}

/**
 * Guidelines for the administration of the medication.
 */
export interface MedicationKnowledgeAdministrationGuidelines {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * Dosage for the medication for the specific guidelines.
   */
  dosage?: MedicationKnowledgeAdministrationGuidelinesDosage[];

  /**
   * Indication for use that apply to the specific administration
   * guidelines.
   */
  indicationCodeableConcept?: CodeableConcept;

  /**
   * Indication for use that apply to the specific administration
   * guidelines.
   */
  indicationReference?: Reference<ObservationDefinition>;

  /**
   * Characteristics of the patient that are relevant to the administration
   * guidelines (for example, height, weight, gender, etc.).
   */
  patientCharacteristics?: MedicationKnowledgeAdministrationGuidelinesPatientCharacteristics[];
}

/**
 * Indication for use that apply to the specific administration
 * guidelines.
 */
export type MedicationKnowledgeAdministrationGuidelinesIndication = CodeableConcept | Reference<ObservationDefinition>;

/**
 * Dosage for the medication for the specific guidelines.
 */
export interface MedicationKnowledgeAdministrationGuidelinesDosage {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The type of dosage (for example, prophylaxis, maintenance,
   * therapeutic, etc.).
   */
  type: CodeableConcept;

  /**
   * Dosage for the medication for the specific guidelines.
   */
  dosage: Dosage[];
}

/**
 * Characteristics of the patient that are relevant to the administration
 * guidelines (for example, height, weight, gender, etc.).
 */
export interface MedicationKnowledgeAdministrationGuidelinesPatientCharacteristics {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * Specific characteristic that is relevant to the administration
   * guideline (e.g. height, weight, gender).
   */
  characteristicCodeableConcept?: CodeableConcept;

  /**
   * Specific characteristic that is relevant to the administration
   * guideline (e.g. height, weight, gender).
   */
  characteristicQuantity?: Quantity;

  /**
   * The specific characteristic (e.g. height, weight, gender, etc.).
   */
  value?: string[];
}

/**
 * Specific characteristic that is relevant to the administration
 * guideline (e.g. height, weight, gender).
 */
export type MedicationKnowledgeAdministrationGuidelinesPatientCharacteristicsCharacteristic = CodeableConcept | Quantity;

/**
 * The price of the medication.
 */
export interface MedicationKnowledgeCost {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The category of the cost information.  For example, manufacturers'
   * cost, patient cost, claim reimbursement cost, actual acquisition cost.
   */
  type: CodeableConcept;

  /**
   * The source or owner that assigns the price to the medication.
   */
  source?: string;

  /**
   * The price of the medication.
   */
  cost: Money;
}

/**
 * Specifies descriptive properties of the medicine, such as color,
 * shape, imprints, etc.
 */
export interface MedicationKnowledgeDrugCharacteristic {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * A code specifying which characteristic of the medicine is being
   * described (for example, colour, shape, imprint).
   */
  type?: CodeableConcept;

  /**
   * Description of the characteristic.
   */
  valueCodeableConcept?: CodeableConcept;

  /**
   * Description of the characteristic.
   */
  valueString?: string;

  /**
   * Description of the characteristic.
   */
  valueQuantity?: Quantity;

  /**
   * Description of the characteristic.
   */
  valueBase64Binary?: string;
}

/**
 * Description of the characteristic.
 */
export type MedicationKnowledgeDrugCharacteristicValue = CodeableConcept | Quantity | string;

/**
 * Identifies a particular constituent of interest in the product.
 */
export interface MedicationKnowledgeIngredient {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The actual ingredient - either a substance (simple ingredient) or
   * another medication.
   */
  itemCodeableConcept?: CodeableConcept;

  /**
   * The actual ingredient - either a substance (simple ingredient) or
   * another medication.
   */
  itemReference?: Reference<Substance>;

  /**
   * Indication of whether this ingredient affects the therapeutic action
   * of the drug.
   */
  isActive?: boolean;

  /**
   * Specifies how many (or how much) of the items there are in this
   * Medication.  For example, 250 mg per tablet.  This is expressed as a
   * ratio where the numerator is 250mg and the denominator is 1 tablet.
   */
  strength?: Ratio;
}

/**
 * The actual ingredient - either a substance (simple ingredient) or
 * another medication.
 */
export type MedicationKnowledgeIngredientItem = CodeableConcept | Reference<Substance>;

/**
 * The time course of drug absorption, distribution, metabolism and
 * excretion of a medication from the body.
 */
export interface MedicationKnowledgeKinetics {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The drug concentration measured at certain discrete points in time.
   */
  areaUnderCurve?: Quantity[];

  /**
   * The median lethal dose of a drug.
   */
  lethalDose50?: Quantity[];

  /**
   * The time required for any specified property (e.g., the concentration
   * of a substance in the body) to decrease by half.
   */
  halfLifePeriod?: Duration;
}

/**
 * Categorization of the medication within a formulary or classification
 * system.
 */
export interface MedicationKnowledgeMedicineClassification {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The type of category for the medication (for example, therapeutic
   * classification, therapeutic sub-classification).
   */
  type: CodeableConcept;

  /**
   * Specific category assigned to the medication (e.g. anti-infective,
   * anti-hypertensive, antibiotic, etc.).
   */
  classification?: CodeableConcept[];
}

/**
 * The program under which the medication is reviewed.
 */
export interface MedicationKnowledgeMonitoringProgram {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * Type of program under which the medication is monitored.
   */
  type?: CodeableConcept;

  /**
   * Name of the reviewing program.
   */
  name?: string;
}

/**
 * Associated documentation about the medication.
 */
export interface MedicationKnowledgeMonograph {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The category of documentation about the medication. (e.g. professional
   * monograph, patient education monograph).
   */
  type?: CodeableConcept;

  /**
   * Associated documentation about the medication.
   */
  source?: Reference<DocumentReference | Media>;
}

/**
 * Information that only applies to packages (not products).
 */
export interface MedicationKnowledgePackaging {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * A code that defines the specific type of packaging that the medication
   * can be found in (e.g. blister sleeve, tube, bottle).
   */
  type?: CodeableConcept;

  /**
   * The number of product units the package would contain if fully loaded.
   */
  quantity?: Quantity;
}

/**
 * Regulatory information about a medication.
 */
export interface MedicationKnowledgeRegulatory {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The authority that is specifying the regulations.
   */
  regulatoryAuthority: Reference<Organization>;

  /**
   * Specifies if changes are allowed when dispensing a medication from a
   * regulatory perspective.
   */
  substitution?: MedicationKnowledgeRegulatorySubstitution[];

  /**
   * Specifies the schedule of a medication in jurisdiction.
   */
  schedule?: MedicationKnowledgeRegulatorySchedule[];

  /**
   * The maximum number of units of the medication that can be dispensed in
   * a period.
   */
  maxDispense?: MedicationKnowledgeRegulatoryMaxDispense;
}

/**
 * The maximum number of units of the medication that can be dispensed in
 * a period.
 */
export interface MedicationKnowledgeRegulatoryMaxDispense {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The maximum number of units of the medication that can be dispensed.
   */
  quantity: Quantity;

  /**
   * The period that applies to the maximum number of units.
   */
  period?: Duration;
}

/**
 * Specifies the schedule of a medication in jurisdiction.
 */
export interface MedicationKnowledgeRegulatorySchedule {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * Specifies the specific drug schedule.
   */
  schedule: CodeableConcept;
}

/**
 * Specifies if changes are allowed when dispensing a medication from a
 * regulatory perspective.
 */
export interface MedicationKnowledgeRegulatorySubstitution {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * Specifies the type of substitution allowed.
   */
  type: CodeableConcept;

  /**
   * Specifies if regulation allows for changes in the medication when
   * dispensing.
   */
  allowed: boolean;
}

/**
 * Associated or related knowledge about a medication.
 */
export interface MedicationKnowledgeRelatedMedicationKnowledge {

  /**
   * Unique id for the element within a resource (for internal references).
   * This may be any string value that does not contain spaces.
   */
  id?: string;

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element. To make the use of extensions
   * safe and manageable, there is a strict set of governance  applied to
   * the definition and use of extensions. Though any implementer can
   * define an extension, there is a set of requirements that SHALL be met
   * as part of the definition of the extension.
   */
  extension?: Extension[];

  /**
   * May be used to represent additional information that is not part of
   * the basic definition of the element and that modifies the
   * understanding of the element in which it is contained and/or the
   * understanding of the containing element's descendants. Usually
   * modifier elements provide negation or qualification. To make the use
   * of extensions safe and manageable, there is a strict set of governance
   * applied to the definition and use of extensions. Though any
   * implementer can define an extension, there is a set of requirements
   * that SHALL be met as part of the definition of the extension.
   * Applications processing a resource are required to check for modifier
   * extensions.
   *
   * Modifier extensions SHALL NOT change the meaning of any elements on
   * Resource or DomainResource (including cannot change the meaning of
   * modifierExtension itself).
   */
  modifierExtension?: Extension[];

  /**
   * The category of the associated medication knowledge reference.
   */
  type: CodeableConcept;

  /**
   * Associated documentation about the associated medication knowledge.
   */
  reference: Reference<MedicationKnowledge>[];
}