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/*! *****************************************************************************
Copyright (c) Microsoft Corporation. All rights reserved.
Licensed under the Apache License, Version 2.0 (the "License"); you may not use
this file except in compliance with the License. You may obtain a copy of the
License at http://www.apache.org/licenses/LICENSE-2.0

THIS CODE IS PROVIDED ON AN *AS IS* BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY IMPLIED
WARRANTIES OR CONDITIONS OF TITLE, FITNESS FOR A PARTICULAR PURPOSE,
MERCHANTABLITY OR NON-INFRINGEMENT.

See the Apache Version 2.0 License for specific language governing permissions
and limitations under the License.
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c(){if(g.call(this,document.querySelector(".introjs-helperLayer")),g.call(this,document.querySelector(".introjs-tooltipReferenceLayer")),g.call(this,document.querySelector(".introjs-disableInteraction")),void 0!==this._currentStep&&null!==this._currentStep){var e=document.querySelector(".introjs-helperNumberLayer"),t=document.querySelector(".introjs-arrow"),r=document.querySelector(".introjs-tooltip");f.call(this,this._introItems[this._currentStep].element,r,t,e)}return z.call(this),this}function u(e,t){var i=!0;if(void 0!==this._introBeforeExitCallback&&(i=this._introBeforeExitCallback.call(this)),t||!1!==i){var o=e.querySelectorAll(".introjs-overlay");o&&o.length&&_(o,function(e){e.style.opacity=0,window.setTimeout(function(){this.parentNode&&this.parentNode.removeChild(this)}.bind(e),500)}.bind(this));var a=e.querySelector(".introjs-helperLayer");a&&a.parentNode.removeChild(a);var s=e.querySelector(".introjs-tooltipReferenceLayer");s&&s.parentNode.removeChild(s);var 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d=c.querySelector(".introjs-helperNumberLayer"),h=c.querySelector(".introjs-tooltiptext"),m=c.querySelector(".introjs-arrow"),b=c.querySelector(".introjs-tooltip");if(n=c.querySelector(".introjs-skipbutton"),r=c.querySelector(".introjs-prevbutton"),t=c.querySelector(".introjs-nextbutton"),a.className=p,b.style.opacity=0,b.style.display="none",null!==d){var S=this._introItems[e.step-2>=0?e.step-2:0];(null!==S&&"forward"===this._direction&&"floating"===S.position||"backward"===this._direction&&"floating"===e.position)&&(d.style.opacity=0)}(i=W(e.element))!==document.body&&q(i,e.element),g.call(o,a),g.call(o,c),_(document.querySelectorAll(".introjs-fixParent"),(function(e){O(e,/introjs-fixParent/g)})),x(),o._lastShowElementTimer&&window.clearTimeout(o._lastShowElementTimer),o._lastShowElementTimer=window.setTimeout((function(){null!==d&&(d.innerHTML=e.step),h.innerHTML=e.intro,b.style.display="block",f.call(o,e.element,b,m,d),o._options.showBullets&&(c.querySelector(".introjs-bullets li > 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E=document.createElement("div"),k=document.createElement("div"),T=document.createElement("div"),P=document.createElement("div"),j=document.createElement("div"),F=document.createElement("div"),N=document.createElement("div"),z=document.createElement("div");E.className=p,k.className="introjs-tooltipReferenceLayer",(i=W(e.element))!==document.body&&q(i,e.element),g.call(o,E),g.call(o,k),this._targetElement.appendChild(E),this._targetElement.appendChild(k),T.className="introjs-arrow",j.className="introjs-tooltiptext",j.innerHTML=e.intro,F.className="introjs-bullets",!1===this._options.showBullets&&(F.style.display="none");var D=document.createElement("ul");D.setAttribute("role","tablist");var R=function(){o.goToStep(this.getAttribute("data-stepnumber"))};_(this._introItems,(function(t,r){var 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M=document.createElement("span");!0===this._options.showStepNumbers&&(M.className="introjs-helperNumberLayer",M.innerHTML=e.step,k.appendChild(M)),P.appendChild(T),k.appendChild(P),(t=document.createElement("a")).onclick=function(){o._introItems.length-1!==o._currentStep&&s.call(o)},v(t),t.innerHTML=this._options.nextLabel,(r=document.createElement("a")).onclick=function(){0!==o._currentStep&&l.call(o)},v(r),r.innerHTML=this._options.prevLabel,(n=document.createElement("a")).className=this._options.buttonClass+" introjs-skipbutton ",v(n),n.innerHTML=this._options.skipLabel,n.onclick=function(){o._introItems.length-1===o._currentStep&&"function"==typeof o._introCompleteCallback&&o._introCompleteCallback.call(o),o._introItems.length-1!==o._currentStep&&"function"==typeof o._introExitCallback&&o._introExitCallback.call(o),"function"==typeof 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SVGElement)for(t=e.element.parentNode;null!==e.element.parentNode&&t.tagName&&"body"!==t.tagName.toLowerCase();)"svg"===t.tagName.toLowerCase()&&C(t,"introjs-showElement introjs-relativePosition"),t=t.parentNode;C(e.element,"introjs-showElement");var r=A(e.element,"position");for("absolute"!==r&&"relative"!==r&&"fixed"!==r&&C(e.element,"introjs-relativePosition"),t=e.element.parentNode;null!==t&&t.tagName&&"body"!==t.tagName.toLowerCase();){var n=A(t,"z-index"),i=parseFloat(A(t,"opacity")),o=A(t,"transform")||A(t,"-webkit-transform")||A(t,"-moz-transform")||A(t,"-ms-transform")||A(t,"-o-transform");(/[0-9]+/.test(n)||i<1||"none"!==o&&void 0!==o)&&C(t,"introjs-fixParent"),t=t.parentNode}}(e),void 0!==this._introAfterChangeCallback&&this._introAfterChangeCallback.call(this,e.element)}function w(e,t,r){var n;if("off"!==e&&this._options.scrollToElement&&(n="tooltip"===e?r.getBoundingClientRect():t.element.getBoundingClientRect(),!function(e){var t=e.getBoundingClientRect();return 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Will not be displayed.`});if(t.substance.length>1&&this.handleError({severity:G.warning,message:`antibioticsFetcher: Compound ${JSON.stringify(t)} has more than one substance; this is not expected. Will not be displayed.`}),!t.substance[0].substanceClass)return void this.handleError({severity:G.warning,message:`antibioticsFetcher: Substance ${JSON.stringify(t.substance[0])} has invalid substanceClass data. Will not be displayed.`});const r=t.substance[0].substanceClass.id,n=this.substanceClasses.getById(r);if(!n)return q("AntibioticsFetcher: Substance class for %o not found within %o.",t.substance[0],this.substanceClasses.getAsArray()),void this.handleError({severity:G.warning,message:`AntibioticsFetcher: Substance class with ID ${r} not found for antibiotic ${JSON.stringify(t)}. Will not be displayed.`});const i=new H(t.id,t.name,n,{iv:t.intravenous,po:t.perOs,identifier:t.identifier});this.store.add(i)})}}class K extends L{}var Q,Y;function X(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const Z=N()("infect:SubstanceClass");var ee=(Y=X((Q=class e{constructor(t,r,n,i={}){var o,a,s,l;o=this,a="_used",l=this,(s=Y)&&Object.defineProperty(o,a,{enumerable:s.enumerable,configurable:s.configurable,writable:s.writable,value:s.initializer?s.initializer.call(l):void 0});const c={id:t,name:r,parent:n,properties:i};if(Z("Create SubstanceClass for data %o",c),void 0===t)throw new Error(`SubstanceClass: Constructor argument 'id' must be \n\t\t\tset, is undefined for ${JSON.stringify(c)}.`);if("string"!=typeof r)throw new Error(`SubstanceClass: Argument 'name' must be\n\t\t\ta string, is ${typeof r}. 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this._used}}).prototype,"_used",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return!1}}),X(Q.prototype,"setUsed",[T.k],Object.getOwnPropertyDescriptor(Q.prototype,"setUsed"),Q.prototype),X(Q.prototype,"used",[T.m],Object.getOwnPropertyDescriptor(Q.prototype,"used"),Q.prototype),Q);const te=N()("infect:SubstanceClassesFetcher");class re extends U{handleData(e){te("Handle data %o",e);const t=function(e){let t=[];return[...e].sort((e,t)=>e.left-t.left).map(e=>{const{left:r,right:n,...i}=e;return t=t.filter(t=>t.right>e.right),t.length&&(i.parent=t[t.length-1].item),e.right>e.left+1&&t.push({item:i,right:e.right}),i})}(e.slice(0)),r=t.find(e=>"penicilline"===e.identifier),n=t.find(e=>"penicillinase-stable penicillin"===e.identifier);r&&n||console.error("Penicillin or stable not found, are %o and %o",r,n);const i=t.indexOf(n);t.splice(i+1,0,{id:-1,identifier:"betalactamplusinhibitor",color:null,name:"Beta-lactam + inhibitor",parent:r}),t.forEach((e,t)=>{const r={};e.color&&(r.color=e.color),r.order=t;const n=e.parent?this.store.getById(e.parent.id):void 0,i=new ee(e.id,e.name,n,r);this.store.add(i)}),te("%d substance classes added to store",this.store.get().size)}}class ne extends L{}var ie,oe;var ae,se,le,ce,ue,fe,pe=(ie=class{constructor(e,t,r={}){var n,i,o,a;n=this,i="_hasDataForResistances",a=this,(o=oe)&&Object.defineProperty(n,i,{enumerable:o.enumerable,configurable:o.configurable,writable:o.writable,value:o.initializer?o.initializer.call(a):void 0});const s={id:e,name:t,properties:r};if(void 0===e)throw new Error(`Bacterium: Constructor argument id is required, \n\t\t\tis currently ${e} for ${JSON.stringify(s)}.`);if("string"!=typeof t)throw new Error(`Bacterium: Constructor argument name must\n\t\t\tbe a string, is currently ${typeof t} for ${JSON.stringify(s)}.`);this.id=e,this.name=t,Object.keys(r).forEach(e=>{this[e]=r[e]})}},ae=ie.prototype,se="_hasDataForResistances",le=[T.B],ce={configurable:!0,enumerable:!0,writable:!0,initializer:function(){return!1}},fe={},Object.keys(ce).forEach((function(e){fe[e]=ce[e]})),fe.enumerable=!!fe.enumerable,fe.configurable=!!fe.configurable,("value"in fe||fe.initializer)&&(fe.writable=!0),fe=le.slice().reverse().reduce((function(e,t){return t(ae,se,e)||e}),fe),ue&&void 0!==fe.initializer&&(fe.value=fe.initializer?fe.initializer.call(ue):void 0,fe.initializer=void 0),void 0===fe.initializer&&(Object.defineProperty(ae,se,fe),fe=null),oe=fe,ie);const de=N()("infect:BacteriaFetcher");class he extends U{constructor(e){super(e);const{dependentStores:t}=e;t&&([this.rdaCounter]=t)}handleData(e){e.forEach(e=>{if(this.rdaCounter&&!this.rdaCounter.hasItem(W.bacterium,e.id))return void de("Bacterium %o has not RDA data, remove");const t={aerobic:e.aerobic||e.aerobicOptional,anaerobic:e.anaerobic||e.anaerobicOptional,shape:e.shape?e.shape.name:void 0,gram:e.gramPositive,shortName:e.shortName},r=new pe(e.id,e.name,t);this.store.add(r)})}}class me extends L{}var ge,ye,ve=Object.freeze({discDiffusion:{identifier:"discDiffusion",precision:4},mic:{identifier:"mic",precision:5},qualitative:{identifier:"qualitative",precision:10}});function be(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let we=(ye=be((ge=class{constructor(e,t,r,n,i){if(function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"quantitativeData",ye,this),!ve[e])throw new Error(`ResistanceValue: Type ${e} not known, use one of ${Object.keys(ve).join(", ")}.`);if(void 0!==t&&"number"!=typeof t)throw new Error(`ResistanceValue: value must either be undefined if it's unknown at the current time or a number; is ${t} instead.`);if(r%1!=0)throw new Error("ResistanceValue: Sample size must be an integer");if(i&&("object"!=typeof i||null===i))throw new Error(`ResistanceValue: If data is passed, it must be an object; you passed ${JSON.stringify(i)} instead.`);if(n){if(!Array.isArray(n))throw new Error("ResistanceValue: Confidence interval must be an array.");if(2!==n.length)throw new Error("ResistanceValue: Confidence interval must contain two 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"+JSON.stringify(e.slots));if(!e.slots.every(e=>"number"==typeof e.value&&"number"==typeof e.sampleCount))throw new Error("Resistance: Quantitative slot entries do not fulfill the expected format, are "+JSON.stringify(e.slots));this.quantitativeData=e}}).prototype,"quantitativeData",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return{}}}),be(ge.prototype,"setQuantitativeData",[T.k],Object.getOwnPropertyDescriptor(ge.prototype,"setQuantitativeData"),ge.prototype),ge);var xe,_e;function Se(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Ee=(_e=Se((xe=class{constructor(e,t,r){if(function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"values",_e,this),!Array.isArray(e))throw new Error("Resistance: First argument must be an Array of resistance values");if(!t)throw new Error("Resistance: Argument antibiotic is required.");if(!r)throw new Error("Resistance: Argument bacterium is required.");e.forEach(e=>this.addResistanceValue(e)),this.antibiotic=t,this.bacterium=r}addResistanceValue(e){this.values.push(new we(e.type,e.value,e.sampleSize,e.confidenceInterval,e.data))}getValuesByPrecision(){return this.values.slice().sort((e,t)=>e.type.precision>t.type.precision?-1:1)}}).prototype,"values",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return[]}}),Se(xe.prototype,"addResistanceValue",[T.k],Object.getOwnPropertyDescriptor(xe.prototype,"addResistanceValue"),xe.prototype),xe);const ke=N()("infect:ResistancesFetcher");class Ce extends U{constructor(e){super(e),this.dataHandled=0;const{handleError:t,dependentStores:r}=e,[n,i]=r;this.stores={antibiotics:n,bacteria:i},this.handleError=t}async getData(...e){this.latestCallURL=this.url,await super.getData(...e)}async getDataForFilters(e){this.baseUrl||(this.baseUrl=this.url),this.url=`${this.baseUrl}?filter=${JSON.stringify(e)}`,await this.getData(),ke("Data for filters gotten")}handleData(e,t){if(ke("Handle data %o",e),this.dataHandled+=1,t!==this.latestCallURL)return void ke("Data belongs to URL %s, latest URL is %s; drop data.",t,this.latestCallURL);if(this.store.clear(),!e.values||!e.values.length)return void ke("Values missing for %o",e);let r=0;e.values.forEach(e=>{r++;const t=this.createResistance(e);t&&this.store.add(t)}),ke(`Added ${r} resistances.`)}createResistance(e){const t=Array.from(this.stores.bacteria.get().values()),r=Array.from(this.stores.antibiotics.get().values()),n=t.find(t=>t.id===e.microorganismId),i=r.find(t=>t.id===e.compoundSubstanceId);if(!i)return this.handleError({severity:G.warning,message:`ResistancesFetcher: Antibiotic with ID ${e.compoundSubstanceId} missing, resistance ${JSON.stringify(e)} cannot be displayed.`}),void console.error("Antibiotic for resistance %o missing; antibiotics are %o",e,r);if(!n)return this.handleError({severity:G.warning,message:`ResistancesFetcher: Bacterium with ID ${e.microorganismId} missing, resistance ${JSON.stringify(e)} cannot be displayed.`}),void console.error("Bacterium for resistance %o missing; bacteria are %o",e,t);const o=this.createResistanceValues(e);let a;try{a=new Ee(o,i,n)}catch(e){return void this.handleError({severity:G.warning,message:`Resistance for ${i.name} and ${n.name} cannot be displayed: ${e.message}.`})}if(!this.store.hasWithId(a))return a;console.warn(`ResistanceFetcher: Resistance ${JSON.stringify(e)} is a duplicate; an entry for the same bacterium and antibiotic does exist.`)}createResistanceValues(e){const t=[];return e.resistanceQualitativeCount&&t.push({type:"qualitative",value:e.resistantPercent/100,sampleSize:e.resistanceQualitativeCount,confidenceInterval:[e.confidenceInterval.lowerBound/100,e.confidenceInterval.upperBound/100],data:{resistant:e.resistant,susceptible:e.susceptible,intermediate:e.intermediate}}),e.resistanceMICCount&&t.push({type:"mic",sampleSize:e.resistanceMICCount}),e.resistanceDiscDiffusionCount&&t.push({type:"discDiffusion",sampleSize:e.resistanceDiscDiffusionCount}),t}}function Oe(e,t){return{added:t.filter(t=>-1===e.indexOf(t)),removed:e.filter(e=>-1===t.indexOf(e)),unchanged:e.filter(e=>t.indexOf(e)>-1)}}const Ae=N()("infect:calculateXPositions");var Te,Pe=r(94),je=r.n(Pe);function Fe(e,t){if(!e||"object"!=typeof e)throw new Error(`doFiltersMatch: target must be an object, is ${typeof e}.`);if(!Array.isArray(t))throw new Error("doFiltersMatch: originalFilters must be an array.");const r=t.slice(0);for(;r.length;){const t=r.filter(e=>je()(e.property,r[0].property));if(0===t.filter(t=>Ne(e,t)).length)return!1;t.forEach(e=>r.splice(r.indexOf(e),1))}return!0}function Ne(e,t){return e.hasOwnProperty(t.property.name)&&e[t.property.name]===t.value}var ze,De=(function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((Te=class{constructor(e,t){this.antibiotic=e,this._matrixView=t}setDimensions(e,t){this._matrixView.setAntibioticLabelDimensions(this,e,t)}get visible(){const e=this._matrixView.selectedFilters.getFiltersByType("antibiotic");if(!Fe(this.antibiotic,e))return!1;const t=this.antibiotic.getSubstanceClasses(),r=this._matrixView.selectedFilters.getFiltersByType("substanceClass");return t.some(e=>Fe(e,r))}}).prototype,"visible",[T.m],Object.getOwnPropertyDescriptor(Te.prototype,"visible"),Te.prototype),Te),Re=r(53),Ie=r.n(Re);function Me(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const Le=N()("infect:ResistanceMatrixView");let Ve=(Me((ze=class{constructor(e,t){this._matrixView=t,this.resistance=e}_getRelativeColorValue(e,t=0,r=1){return t+(r-t)*e}get visible(){return!(!this.xPosition||!this.yPosition)}get mostPreciseValue(){return this.resistance.getValuesByPrecision()[0]}get radius(){const e=this._matrixView.sampleSizeExtremes.min,t=(Math.min(this.mostPreciseValue.sampleSize,1e3)-e)/(1e3-e)*9+1,r=Math.log10(t)*(1e3-e)+e,n=Math.round(function(e,t,r,n=1){if(e>r)throw new Error(`getRelativeValue: value ${e} must be smaller than max ${r}.`);if(e<t)throw new Error(`getRelativeValue: value ${e} must be larger than min ${t}.`);return r===t?e:(e-t)/(r-t)*n+(1-n)}(r,e,1e3,.5)*this._matrixView.defaultRadius);return Le("Radius for resistance %o is %d",this,n),n}get backgroundColor(){const{type:e,value:t}=this.mostPreciseValue;if(e===ve.mic||e===ve.discDiffusion)return Ie()("#E1E0D5");const r=Math.log10(9*t+1),n=this._getRelativeColorValue(1-r,9,98)/360,i=this._getRelativeColorValue(1-t,.3,1),o=this._getRelativeColorValue(t,.4,.9);return Ie.a.fromRatio({h:n,s:i,l:o})}get fontColor(){const e=this.backgroundColor.clone();return e.darken(50),e.saturate(20),e}get xPosition(){const e=this._matrixView.getAntibioticView(this.resistance.antibiotic);return this._matrixView.xPositions.get(e)}get yPosition(){const e=this._matrixView.getBacteriumView(this.resistance.bacterium);return this._matrixView.yPositions.get(e)}get matchesOffsets(){const e=this._matrixView.getOffsetFilters().filters,t=this.mostPreciseValue,r=t.sampleSize>=e.get("sampleSize").min,n=t.value<=1-e.get("susceptibility").min;return this.mostPreciseValue.type===ve.qualitative?r&&n:r}get displayValue(){const e=new Map([[ve.qualitative,({value:e})=>Math.round(100*(1-e))],[ve.mic,e=>void 0!==e.quantitativeData.percentileValue?e.quantitativeData.percentileValue:"MIC"],[ve.discDiffusion,()=>"DD"]]),t=this.mostPreciseValue;return e.get(t.type)(t)}get mostPreciseResistanceTypeIdentifier(){const e=Object.keys(ve);for(const t of e)if(this.mostPreciseValue.type===ve[t])return t}}).prototype,"visible",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"visible"),ze.prototype),Me(ze.prototype,"mostPreciseValue",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"mostPreciseValue"),ze.prototype),Me(ze.prototype,"radius",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"radius"),ze.prototype),Me(ze.prototype,"backgroundColor",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"backgroundColor"),ze.prototype),Me(ze.prototype,"fontColor",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"fontColor"),ze.prototype),Me(ze.prototype,"xPosition",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"xPosition"),ze.prototype),Me(ze.prototype,"yPosition",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"yPosition"),ze.prototype),Me(ze.prototype,"matchesOffsets",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"matchesOffsets"),ze.prototype),Me(ze.prototype,"displayValue",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"displayValue"),ze.prototype),Me(ze.prototype,"mostPreciseResistanceTypeIdentifier",[T.m],Object.getOwnPropertyDescriptor(ze.prototype,"mostPreciseResistanceTypeIdentifier"),ze.prototype),ze);var Be;function $e(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}var Ue,He=($e((Be=class{constructor(e,t){this.substanceClass=e,this._matrixView=t}get lineColor(){const e=this.substanceClass.getParentSubstanceClasses().length;return Ie.a.fromRatio({h:0,s:0,l:e/this._matrixView.maxAmountOfSubstanceClassHierarchies*.6+.4})}get xPosition(){return this._matrixView.xPositions.get(this)}}).prototype,"lineColor",[T.m],Object.getOwnPropertyDescriptor(Be.prototype,"lineColor"),Be.prototype),$e(Be.prototype,"xPosition",[T.m],Object.getOwnPropertyDescriptor(Be.prototype,"xPosition"),Be.prototype),Be);function Ge(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let We=(Ge((Ue=class{constructor(e,t){this.bacterium=e,this._matrix=t}setWidth(e){e&&this._matrix.setBacteriumLabelWidth(this,e)}get visible(){const e=this._matrix.selectedFilters.getFiltersByType("bacterium");return Fe(this.bacterium,e)}get hasResistanceData(){return this._matrix.resistances.findIndex(({resistance:e})=>e.bacterium===this.bacterium)>-1}}).prototype,"visible",[T.m],Object.getOwnPropertyDescriptor(Ue.prototype,"visible"),Ue.prototype),Ge(Ue.prototype,"hasResistanceData",[T.m],Object.getOwnPropertyDescriptor(Ue.prototype,"hasResistanceData"),Ue.prototype),Ue);var qe,Je,Ke,Qe,Ye,Xe,Ze,et,tt,rt;function nt(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}function it(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const ot=N()("infect:MatrixView");var at,st,lt=(qe=T.B.shallow,Ke=it((Je=class{constructor(){nt(this,"defaultRadius",Ke,this),nt(this,"bacteriumLabelColumnWidth",Qe,this),nt(this,"antibioticLabelRowHeight",Ye,this),nt(this,"space",Xe,this),nt(this,"activeResistance",Ze,this),nt(this,"sampleSizeExtremes",et,this),nt(this,"_resistances",tt,this),nt(this,"greatestSubstanceClassLabelHeight",rt,this),this._antibiotics=T.B.map(),this._substanceClasses=T.B.map(),this._bacteria=T.B.map(),this.spaceBetweenGroups=20,this._antibioticLabelDimensions=new Map,this._bacteriaLabelWidths=new Map,this._substanceClassLabelHeights=new Map}setupDataWatchers(e=[],t=[],r){Object(T.C)(e.status,t=>{t.newValue===z.ready&&e.getAsArray().forEach(e=>{this.addAntibiotic(e)})}),Object(T.C)(t.status,e=>{e.newValue===z.ready&&t.getAsArray().forEach(e=>{this.addBacterium(e)})}),Object(T.C)(t.get(),e=>{"delete"===e.type&&this.removeBacterium(e.oldValue)}),Object(T.C)(r.status,e=>{e.newValue===z.ready&&(this._clearResistances(),r.getAsArray().forEach(e=>{this.addResistance(e)}))})}_clearResistances(){this._resistances.clear()}setOffsetFilters(e){this._offsetFilters=e}getOffsetFilters(){return this._offsetFilters}setSelectedFilters(e){this._selectedFilters=e}get selectedFilters(){return this._selectedFilters}addAntibiotic(e){if(this._antibiotics.has(e.id))throw new Error(`MatrixView: Trying to add antibiotic with duplicate key ${e.id}.`);this._antibiotics.set(e.id,new De(e,this)),ot("Added antibiotic %o, number is %d",e,this._antibiotics.size);e.getSubstanceClasses().forEach(e=>{this._substanceClasses.has(e.id)||this._substanceClasses.set(e.id,new He(e,this))})}get antibiotics(){return Array.from(this._antibiotics.values())}getAntibioticView(e){return this._antibiotics.get(e.id)}get substanceClasses(){return Array.from(this._substanceClasses.values())}get sortedAntibiotics(){return function(e){const t=e.reduce((e,t)=>(e.set(t,t.getSubstanceClasses().slice(0).reverse().map(e=>e.name)),e),new Map);return e.slice(0).sort((e,r)=>{const n=Math.min(t.get(e).length,t.get(r).length);let i=0;for(;i<n;){const o=e.getSubstanceClasses().slice(0).reverse()[i],a=r.getSubstanceClasses().slice(0).reverse()[i];if(o!==a)return void 0!==o.order&&void 0===a.order?-1:void 0===o.order&&void 0!==a.order?1:void 0!==o.order&&void 0!==a.order?o.order-a.order:t.get(e)[i]<t.get(r)[i]?-1:1;if(!(i<n-1))return t.get(e).length!=t.get(r).length?t.get(e).length<t.get(r).length?-1:1:e.name<r.name?-1:1;i++}})}(this.antibiotics.map(e=>e.antibiotic)).map(e=>this._antibiotics.get(e.id))}setAntibioticLabelDimensions(e,t,r){if(t%1!=0||r%1!=0)throw new Error("MatrixView: Width and height for antibiotic labels must be integers.");const n=this._antibioticLabelDimensions.get(e);n&&n.height===r&&n.width===t||(this._antibioticLabelDimensions.set(e,{width:t,height:r}),this._calculateAntibioticLabelRowHeight(),this._calculateDefaultRadius())}_calculateAntibioticLabelRowHeight(){this._antibioticLabelDimensions.size===this.sortedAntibiotics.length&&(this.antibioticLabelRowHeight=Array.from(this._antibioticLabelDimensions.values()).reduce((e,t)=>Math.max(e,t.height),0),ot("antibioticLabelRowHeight is %d",this.antibioticLabelRowHeight))}get xPositions(){const e=function(e,t,r){const n=e.filter(e=>e.visible);Ae("Visible antibiotics are %o",n);const i=new Map;return n.reduce((e,o,a)=>{const s=o.antibiotic.getSubstanceClasses(),l=s.filter(e=>!e.expanded).reverse(),c=l.length&&l[0]===e.contractedSubstanceClass;if(e.contractedSubstanceClass=l.length?l[0]:void 0,c)return e;const u=Oe(e.previousSubstanceClasses,o.antibiotic.getSubstanceClasses());return e.previousSubstanceClasses=o.antibiotic.getSubstanceClasses(),u.removed.forEach(t=>{i.get(t).right=e.x}),u.added.length&&(e.x+=r),u.added.forEach(t=>{i.set(t,{left:e.x})}),e.x+=r,i.set(o,{left:e.x,right:e.x+t}),a===n.length-1&&s.forEach(r=>i.get(r).right=e.x+t),e.x+=t,e},{previousSubstanceClasses:[],contractedSubstanceClass:void 0,x:0}),Ae("xPositions are %o",i),i}(this.sortedAntibiotics,2*this.defaultRadius,this.space),t=new Map;return e.forEach((e,r)=>{const n=r instanceof ee?this._substanceClasses.get(r.id):r;t.set(n,e)}),t}get visibleAntibioticsWidth(){let e=0;return this.xPositions.forEach(t=>{void 0!==t.right&&(e=Math.max(e,t.right))}),e}get maxAmountOfSubstanceClassHierarchies(){return this.antibiotics.reduce((e,t)=>Math.max(e,t.antibiotic.getSubstanceClasses().length),0)}setSubstanceClassHeight(e,t){this._substanceClassLabelHeights.set(e,t),this._substanceClassLabelHeights.size===this.substanceClasses.length&&this._calculateGreatestSubstanceClassLabelHeight()}_calculateGreatestSubstanceClassLabelHeight(){const e=Array.from(this._substanceClassLabelHeights.values());this.greatestSubstanceClassLabelHeight=Math.ceil(e.reduce((e,t)=>Math.max(t,e)),0),ot("greatestSubstanceClassLabelHeight is %d",this.greatestSubstanceClassLabelHeight)}get headerHeight(){return this.antibioticLabelRowHeight?this.antibioticLabelRowHeight+this.spaceBetweenGroups/2+(this.maxAmountOfSubstanceClassHierarchies*this.greatestSubstanceClassLabelHeight||0):0}addResistance(e){this._resistances.push(new Ve(e,this)),this._updateSampleSizeExtremes(e)}get resistances(){return this._resistances}_updateSampleSizeExtremes(e){const t=e.getValuesByPrecision()[0];(0===this.sampleSizeExtremes.min||t.sampleSize<this.sampleSizeExtremes.min)&&(this.sampleSizeExtremes.min=t.sampleSize),t.sampleSize>this.sampleSizeExtremes.max&&(this.sampleSizeExtremes.max=t.sampleSize)}setActiveResistance(e){this.activeResistance=e}setDimensions(e){ot("Set dimensions to %o",e),e&&(this._dimensions&&this._dimensions.height===e.height&&this._dimensions.width===e.width||(this._dimensions={height:e.height,width:e.width},this._calculateDefaultRadius()))}_calculateDefaultRadius(){if(!this._bacteria.size||this._bacteriaLabelWidths.size!==this._bacteria.size)return;if(!this._dimensions)return;if(void 0===this.antibioticLabelRowHeight)return;ot("Calculate default radius");const e=this._antibiotics.size,t=this.sortedAntibiotics.reduce((e,t)=>{if(!e.item)return{count:0,item:t};const r=Oe(e.item.antibiotic.getSubstanceClasses(),t.antibiotic.getSubstanceClasses());return{count:r.removed.length||r.added.length?e.count+1:e.count,item:t}},{count:0,item:void 0}).count;ot("Calculate defaultRadius; bacteriumLabelColumnWidth is %d, numberOfAntibiotics %d, numberOfSubstanceClassChanges %d, width %d",this.bacteriumLabelColumnWidth,e,t,this._dimensions.width);const r=this._dimensions.width-this.space-this.bacteriumLabelColumnWidth-this.antibioticLabelRowHeight,n=(e+t)*this.space;let i=Math.floor((r-n)/e/2);i=Math.max(i,1),i=Math.min(i,25),this.defaultRadius=i,ot("Available space: %d. Whitespace: %d. Default radius %d.",r,n,this.defaultRadius)}addBacterium(e){this._bacteria.set(e.id,new We(e,this))}removeBacterium(e){this._bacteria.delete(e.id)}get sortedBacteria(){return Array.from(this._bacteria.values()).sort((e,t)=>e.bacterium.name<t.bacterium.name?-1:1)}get sortedVisibleBacteria(){return this.sortedBacteria.filter(e=>e.visible)}getBacteriumView(e){return this._bacteria.get(e.id)}setBacteriumLabelWidth(e,t){ot("Set width of bacteriumLabel %o to %d",e,t),this._bacteriaLabelWidths.has(e)&&this._bacteriaLabelWidths.get(e)===t||(this._bacteriaLabelWidths.set(e,t),ot("Set width of %o to %o",e,t),this._calculateBacteriumLabelColumnWidth(),this._calculateDefaultRadius())}_calculateBacteriumLabelColumnWidth(){this._bacteriaLabelWidths.size===this.sortedBacteria.length&&(this.bacteriumLabelColumnWidth=Math.ceil(Array.from(this._bacteriaLabelWidths.values()).reduce((e,t)=>Math.max(e,t),0)),ot("bacteriumLabelColumnWidth is %d",this.bacteriumLabelColumnWidth))}get yPositions(){ot("calculate yPositions");const e=new Map;return this.sortedBacteria.filter(e=>e.visible).forEach((t,r)=>{e.set(t,{top:r*(2*this.defaultRadius+this.space)})}),e}get visibleBacteriaHeight(){return Array.from(this.yPositions.values()).reduce((e,t)=>t&&t.top>e?t.top:e,0)+(this.defaultRadius||0)}}).prototype,"defaultRadius",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){}}),Qe=it(Je.prototype,"bacteriumLabelColumnWidth",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){}}),Ye=it(Je.prototype,"antibioticLabelRowHeight",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){}}),Xe=it(Je.prototype,"space",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return 3}}),Ze=it(Je.prototype,"activeResistance",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){}}),et=it(Je.prototype,"sampleSizeExtremes",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return{min:0,max:0}}}),tt=it(Je.prototype,"_resistances",[qe],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return[]}}),rt=it(Je.prototype,"greatestSubstanceClassLabelHeight",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){}}),it(Je.prototype,"setupDataWatchers",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"setupDataWatchers"),Je.prototype),it(Je.prototype,"_clearResistances",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"_clearResistances"),Je.prototype),it(Je.prototype,"addAntibiotic",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"addAntibiotic"),Je.prototype),it(Je.prototype,"antibiotics",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"antibiotics"),Je.prototype),it(Je.prototype,"substanceClasses",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"substanceClasses"),Je.prototype),it(Je.prototype,"sortedAntibiotics",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"sortedAntibiotics"),Je.prototype),it(Je.prototype,"setAntibioticLabelDimensions",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"setAntibioticLabelDimensions"),Je.prototype),it(Je.prototype,"_calculateAntibioticLabelRowHeight",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"_calculateAntibioticLabelRowHeight"),Je.prototype),it(Je.prototype,"xPositions",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"xPositions"),Je.prototype),it(Je.prototype,"visibleAntibioticsWidth",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"visibleAntibioticsWidth"),Je.prototype),it(Je.prototype,"maxAmountOfSubstanceClassHierarchies",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"maxAmountOfSubstanceClassHierarchies"),Je.prototype),it(Je.prototype,"setSubstanceClassHeight",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"setSubstanceClassHeight"),Je.prototype),it(Je.prototype,"_calculateGreatestSubstanceClassLabelHeight",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"_calculateGreatestSubstanceClassLabelHeight"),Je.prototype),it(Je.prototype,"headerHeight",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"headerHeight"),Je.prototype),it(Je.prototype,"addResistance",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"addResistance"),Je.prototype),it(Je.prototype,"resistances",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"resistances"),Je.prototype),it(Je.prototype,"_updateSampleSizeExtremes",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"_updateSampleSizeExtremes"),Je.prototype),it(Je.prototype,"setActiveResistance",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"setActiveResistance"),Je.prototype),it(Je.prototype,"setDimensions",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"setDimensions"),Je.prototype),it(Je.prototype,"_calculateDefaultRadius",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"_calculateDefaultRadius"),Je.prototype),it(Je.prototype,"addBacterium",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"addBacterium"),Je.prototype),it(Je.prototype,"removeBacterium",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"removeBacterium"),Je.prototype),it(Je.prototype,"sortedBacteria",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"sortedBacteria"),Je.prototype),it(Je.prototype,"sortedVisibleBacteria",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"sortedVisibleBacteria"),Je.prototype),it(Je.prototype,"setBacteriumLabelWidth",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"setBacteriumLabelWidth"),Je.prototype),it(Je.prototype,"_calculateBacteriumLabelColumnWidth",[T.k],Object.getOwnPropertyDescriptor(Je.prototype,"_calculateBacteriumLabelColumnWidth"),Je.prototype),it(Je.prototype,"yPositions",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"yPositions"),Je.prototype),it(Je.prototype,"visibleBacteriaHeight",[T.m],Object.getOwnPropertyDescriptor(Je.prototype,"visibleBacteriaHeight"),Je.prototype),Je);function ct(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const ut=N()("infect:Guideline");let ft=(st=ct((at=class{constructor({id:e,name:t,link:r,diagnoses:n=[],markdownDisclaimer:i="",contactEmail:o}={}){if(function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"selectedDiagnosis",st,this),"number"!=typeof e)throw new Error(`Guideline: Constructor argument id must be a number, is ${e}.`);if("string"!=typeof t)throw new Error(`Guideline: Constructor argument name must be a string, is ${t}.`);if("string"!=typeof r)throw new Error(`Guideline: Constructor argument link must be a string, is ${r}.`);this.id=e,this.name=t,this.link=r,this.diagnoses=n,this.markdownDisclaimer=i,this.contactEmail=o}selectDiagnosis(e){if(void 0!==e&&!this.diagnoses.includes(e))throw new Error(`Guideline: Selected diagnosis ${JSON.stringify(e)} is not part of this guideline's diagnoses.`);ut("Select diagnosis %o",e),this.selectedDiagnosis=e}}).prototype,"selectedDiagnosis",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:null}),ct(at.prototype,"selectDiagnosis",[T.k],Object.getOwnPropertyDescriptor(at.prototype,"selectDiagnosis"),at.prototype),at);var pt,dt,ht;function mt(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}function gt(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const yt=N()("infect:DrawerViewModel");let vt=(dt=gt((pt=class{constructor(){mt(this,"isOpen",dt,this),this.validContentTypes=new Map([[ft,"guideline"],[Ee,"resistance"]]),mt(this,"content",ht,this)}open(){yt("Open drawer"),this.isOpen=!0}close(){yt("Close drawer"),this.isOpen=!1}setContent(e){if(void 0!==e&&!this.validContentTypes.has(e.constructor)){const t=Array.from(this.validContentTypes.keys()).map(e=>e.name).join(", ");throw new Error(`DrawerViewModel: For now, drawer only supports ${t} as content, make sure you pass a corresponding instance. Instead, you passed ${JSON.stringify(e)}.`)}this.content=e,void 0===e?this.close():this.open()}get contentType(){if(this.content)return this.validContentTypes.get(this.content.constructor)}}).prototype,"isOpen",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return!1}}),ht=gt(pt.prototype,"content",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:null}),gt(pt.prototype,"open",[T.k],Object.getOwnPropertyDescriptor(pt.prototype,"open"),pt.prototype),gt(pt.prototype,"close",[T.k],Object.getOwnPropertyDescriptor(pt.prototype,"close"),pt.prototype),gt(pt.prototype,"setContent",[T.k],Object.getOwnPropertyDescriptor(pt.prototype,"setContent"),pt.prototype),gt(pt.prototype,"contentType",[T.m],Object.getOwnPropertyDescriptor(pt.prototype,"contentType"),pt.prototype),pt);var bt,wt,xt,_t=Object.freeze({region:"region",ageGroup:"ageGroup",bacterium:"bacterium",antibiotic:"antibiotic",substanceClass:"substanceClass",hospitalStatus:"hospitalStatus",animal:"animal",sampleSource:"sampleSource"});function St(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Et=(bt=T.B.shallow,xt=St((wt=class{constructor(){!function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"_values",xt,this)}get values(){return this._values.slice()}set values(e){throw new Error("SearchableMap: Use add method to add items.")}add(e){if(!e||"object"!=typeof e)throw`SearchableMap: Only add objects; type added is ${typeof e}.`;return this._values.push(e),[e]}remove(e){throw new Error("SearchableMap: remove method was not yet implemented.")}getBy(e){return this._values.filter(t=>Object.keys(e).every(r=>t.hasOwnProperty(r)&&t[r]===e[r]))}}).prototype,"_values",[bt],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return[]}}),St(wt.prototype,"values",[T.m],Object.getOwnPropertyDescriptor(wt.prototype,"values"),wt.prototype),St(wt.prototype,"add",[T.k],Object.getOwnPropertyDescriptor(wt.prototype,"add"),wt.prototype),St(wt.prototype,"remove",[T.k],Object.getOwnPropertyDescriptor(wt.prototype,"remove"),wt.prototype),wt);var kt,Ct=r(95),Ot=r.n(Ct);const At=N()("infect:PropertyMap");let Tt=(function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((kt=class{constructor(){this._properties=new Et,this._propertyValues=new Et,this._configurations={},this._fuseOptions={shouldSort:!0,threshold:.3,tokenize:!0,minMatchCharLength:1,keys:[{name:"niceValue",weight:.7},{name:"property.niceName",weight:.3}]}}get propertyValues(){return this._propertyValues}getValuesForProperty(e,t){const r=this._properties.getBy({entityType:e,name:t});if(!r.length)return[];const n=this._propertyValues.getBy({property:r[0]});return At("Properties for %s / %s are %o; values are %o",e,t,r,n),n}getPropertiesForEntityType(e){return this._properties.getBy({entityType:e})}addConfiguration(e,t){this._configurations[e]=t}addEntity(e,t,r){const n=this._configurations[e];if(!n)throw new Error("PropertyMap: Before you can add an entity, you have to provide a configuration matching it.");Object.keys(t).forEach(r=>{if(!n[r])return;const i=t[r];if(void 0===i)return;let o=this._properties.getBy({entityType:e,name:r});if(!o.length){const t=this._getTranslation(n[r].translation,r);o=this._properties.add({entityType:e,name:r,niceName:t})}if(this._propertyValues.getBy({property:o[0],value:i}).length)return;const a=n[r].valueTranslations;let s;if("function"==typeof a)s=this._getTranslation(a,i,t);else{if(!Array.isArray(a))throw`PropertyMap: Unknown type of valueTranslations; needs to be an Array or a Function, is ${a}.`;s=this._getTranslation(a.find(e=>e.value===i).translation,i,t)}const l={property:o[0],value:i,niceValue:s};At("Added %o, entity was %o",l,t),this._propertyValues.add(l)})}search(e){return new Ot.a(this._propertyValues.values,this._fuseOptions).search(e)}_getTranslation(e,t,r){return e?"string"==typeof e?e:"function"==typeof e?e(t,r):void 0:(console.warn(`PropertyMap: Translation for value ${t} is missing; return original value.`),t)}}).prototype,"propertyValues",[T.m],Object.getOwnPropertyDescriptor(kt.prototype,"propertyValues"),kt.prototype),kt);var Pt;function jt(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Ft=(jt((Pt=class{constructor(){this._filters=T.B.map()}setFilter(e,t,r){if(!e)throw new Error("OffsetFilters: dataType not set.");const n=["min","max"];if(!t||-1===n.indexOf(t))throw new Error(`OffsetFilters: Invalid rangeType, pass one of ${n.join(",")}.`);this.filters.get(e)||this.filters.set(e,{min:void 0,max:void 0}),this.filters.get(e)[t]=r}get filters(){return this._filters}}).prototype,"setFilter",[T.k],Object.getOwnPropertyDescriptor(Pt.prototype,"setFilter"),Pt.prototype),jt(Pt.prototype,"filters",[T.m],Object.getOwnPropertyDescriptor(Pt.prototype,"filters"),Pt.prototype),Pt);var Nt,zt,Dt,Rt;function It(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}function Mt(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const Lt=N()("infect:SelectedFilters");let Vt=(Nt=T.B.shallow,Dt=Mt((zt=class{constructor(){It(this,"_selectedFilters",Dt,this),It(this,"filterChanges",Rt,this)}addFilter(e){Lt("Add filter %o, filters were %o",e,this._selectedFilters.slice());this._selectedFilters.find(t=>je()(t,e))?console.warn("Tried to add duplicate entry %o",e):(this.filterChanges++,this._selectedFilters.push(e),Lt("Added filters, are now %o",this._selectedFilters))}removeFilter(e){Lt("Remove filter %o, filters are %o",e,this._selectedFilters.slice());const t=this._selectedFilters.indexOf(this.findFilter(e));-1!==t?(this.filterChanges++,this._selectedFilters.splice(t,1)):Lt("Filter %o not found in selectedFilters %o",e,this._selectedFilters)}toggleFilter(e){Lt("Toggle filter %o",e),this.isSelected(e)?this.removeFilter(e):this.addFilter(e)}findFilter(e){return this._selectedFilters.find(t=>t===e)}isSelected(e){const t=this.findFilter(e);return Lt("Is filter %o selected? %o",e,!!t),!!t}get filters(){return this._selectedFilters.slice()}get 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0}}),Mt(zt.prototype,"addFilter",[T.k],Object.getOwnPropertyDescriptor(zt.prototype,"addFilter"),zt.prototype),Mt(zt.prototype,"removeFilter",[T.k],Object.getOwnPropertyDescriptor(zt.prototype,"removeFilter"),zt.prototype),Mt(zt.prototype,"toggleFilter",[T.k],Object.getOwnPropertyDescriptor(zt.prototype,"toggleFilter"),zt.prototype),Mt(zt.prototype,"filters",[T.m],Object.getOwnPropertyDescriptor(zt.prototype,"filters"),zt.prototype),Mt(zt.prototype,"originalFilters",[T.m],Object.getOwnPropertyDescriptor(zt.prototype,"originalFilters"),zt.prototype),Mt(zt.prototype,"removeAllFilters",[T.k],Object.getOwnPropertyDescriptor(zt.prototype,"removeAllFilters"),zt.prototype),zt);var Bt,$t,Ut;let Ht=(Bt=T.B.shallow,Ut=function(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}(($t=class{constructor(e){!function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"mostUsedFilters",Ut,this),this._selectedFilters=e,this._setupSelectedFiltersWatcher()}_setupSelectedFiltersWatcher(){Object(T.E)(()=>this._selectedFilters.filterChanges,()=>{this._selectedFilters.originalFilters.forEach(e=>{const t=this.mostUsedFilters.find(t=>t.filter===e);t?t.count++:this.mostUsedFilters.push({filter:e,count:1})})})}}).prototype,"mostUsedFilters",[Bt],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return[]}}),$t);var Gt;const Wt=N()("infect:PopulationFilterUpdater");let qt=(function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((Gt=class{constructor(e,t,r,n,i){this.previousFilters="",this.resistancesFetcher=e,this.selectedFilters=t,this.ageGroupStore=r,this.handleError=n,this.dataVersionStatusIdentifiers=i}setup(){this.setupWatcher()}get filterHeaders(){const e=this.selectedFilters.getFiltersByType(_t.region),t=this.selectedFilters.getFiltersByType(_t.hospitalStatus),r=this.selectedFilters.getFiltersByType(_t.animal),n=this.selectedFilters.getFiltersByType(_t.sampleSource),i={};this.dataVersionStatusIdentifiers&&this.dataVersionStatusIdentifiers.length&&(i.dataVersionStatusIdentifier=this.dataVersionStatusIdentifiers);const o={regionIds:e.map(e=>e.value),patientSettingIds:t.map(e=>e.value),animalIds:r.map(e=>e.value),sampleSourceIds:n.map(e=>e.value),ageGroupIntervals:[],...i},a=this.selectedFilters.getFiltersByType(_t.ageGroup);if(a.length){const e=a.map(({value:e})=>e);this.ageGroupStore.getAsArray().filter(t=>e.includes(t.id)).map(({daysTo:e,daysFrom:t})=>({daysTo:e,daysFrom:t})).forEach(e=>o.ageGroupIntervals.push(e))}return o}setupWatcher(){Object(T.E)(()=>this.filterHeaders,async e=>{try{Wt("Selected filters changed, new headers are %o",e),await this.resistancesFetcher.getDataForFilters(e)}catch(e){this.handleError(e)}},{equals:(e,t)=>JSON.stringify(e)===JSON.stringify(t)})}}).prototype,"filterHeaders",[T.m],Object.getOwnPropertyDescriptor(Gt.prototype,"filterHeaders"),Gt.prototype),Gt);const Jt=N()("infect:PopulationFilterFetcher");class Kt extends U{constructor(e){super(e),[this.rdaCounterStore]=e.dependentStores,this.filterValues=e.filterValues,this.rdaCounterType=e.rdaCounterType,this.filterType=e.filterType}handleData(e){Object(T.H)(()=>{e.forEach(e=>{!this.rdaCounterType||this.rdaCounterStore.hasItem(this.rdaCounterType,e.id)?(Jt("Add population filter %o",e),this.filterValues.addEntity(this.filterType,e)):Jt("Population filter %o is not part of RDA, skip it",e)})})}}const Qt=e=>e instanceof Error?{severity:G.error,message:e.stack||e.message,error:e}:e?e.severity&&Object.values(G).includes(e.severity)?e.message&&"string"==typeof e.message?{severity:e.severity,message:e.message}:Qt(new Error(`wrapNotification: Notifications passed to ErrorHandler must include a property "message" which is a string; you passed ${e.message} instead. Your original message is ${JSON.stringify(e)}.`)):Qt(new Error(`wrapNotification: Notifications passed to ErrorHandler must include a property "severity" which is one of ${(Object.keys(G)||[]).join(", ")}; you passed ${e.severity} instead. Your original message is ${JSON.stringify(e)}`)):Qt(new Error(`wrapNotification: Pass an Error or a notification that contains a message and severity property, you passed ${e} instead.`));var Yt,Xt,Zt=Qt;let er=(Xt=function(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}((Yt=class{constructor(e){!function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"hide",Xt,this),this.message=e.message,this.error=e.error,this.severity=e.severity}}).prototype,"hide",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return!1}}),Yt);var tr,rr;function nr(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const ir=N()("infect:NotificationCenter");let or=(rr=nr((tr=class{constructor(){!function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"notifications",rr,this)}handle(e){const t=new er(Zt(e));ir("Handle message %o",t),t.severity!==G.information&&console.error("NotificationCenter handled error/warning %o",e),this.notifications.push(t)}}).prototype,"notifications",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return[]}}),nr(tr.prototype,"handle",[T.k],Object.getOwnPropertyDescriptor(tr.prototype,"handle"),tr.prototype),tr);const ar=N()("infect:updateDrawerFromGuidelines");class sr extends U{handleData(e){const[t]=this.dependentStores;e.forEach(e=>{const r=t.getAsArray().filter(t=>t.guidelineId===e.id);r.forEach(e=>e.removeGuidelineId),this.store.add(new ft({id:e.id,name:e.name,link:e.href,diagnoses:r,markdownDisclaimer:e.markdownDisclaimer,contactEmail:e.contactEmail}))})}}class lr{constructor({id:e,name:t,diagnosisClass:r,link:n,synonyms:i,latestUpdate:o,inducingBacteria:a=[],markdownText:s="",therapies:l=[]}={}){if("number"!=typeof e)throw new Error(`Diagnosis: First constructor argument (id) must be a number, is ${e}.`);if("string"!=typeof t)throw new Error(`Diagnosis: Second constructor argument (name) must be a string, is ${t}.`);if(null!=s&&"string"!=typeof s)throw new Error(`Diagnosis: Constructor argument markdownText must be a string if set, but is ${s}.`);if(i&&(!Array.isArray(i)||i.find(e=>"string"!=typeof e)))throw new Error(`Diagnosis: Constructor argument synonyms must be an Array of Strings, is ${i}.`);this.id=e,this.name=t,this.diagnosisClass=r,this.inducingBacteria=a,this.markdownText=s,this.therapies=l,this.latestUpdate=o,this.link=n,this.synonyms=i}setGuidelineId(e){this.guidelineId=e}removeGuidelineId(){delete this.guidelineId}getTherapiesForAntibiotic(e){return this.therapies.filter(t=>t.containsAntibiotic(e)).sort((e,t)=>e.priorityOrder-t.priorityOrder)}}const cr=N()("infect:DiagnosisFetcher");class ur extends U{constructor(e){super(e);const{handleError:t}=e;this.handleError=t,cr("handleError set to %o",this.handleError)}handleData(e){const[t,r,n,i]=this.dependentStores;e.forEach(e=>{cr("Create model for diagnosis %o",e);const o=r.getAsArray().filter(t=>t.id_diagnosis===e.id).map(t=>{const r=n.getById(t.id_bacterium);return r||this.handleError({severity:G.warning,message:`Bacterium ${t.id_bacterium} could not be found. The results displayed to you will therefore not be complete for diagnosis ${e.name}.`}),r}).filter(e=>void 0!==e),a=i.getAsArray().filter(t=>t.diagnosisId===e.id).sort((e,t)=>e.priority.order-t.priority.order);a.forEach(e=>e.removeDiagnosisId()),cr("Inducing bacteria are %o, therapies are %o",o,a);const s=e.latestUpdates.map(e=>({date:new Date(e.date),name:e.dataSourceName,link:e.dataSourceHref})).sort((e,t)=>t.date.getTime()-e.date.getTime()),l=new lr({id:e.id,name:e.name,diagnosisClass:t.getById(e.id_diagnosisClass),inducingBacteria:o,markdownText:e.markdownText,therapies:a,link:e.href,latestUpdate:s[0],synonyms:e.synonyms});l.setGuidelineId(e.id_guideline),this.store.add(l)})}}class fr{constructor(e,t=[],r=1,n="",i=""){if("number"!=typeof e)throw new Error(`Therapy: First constructor argument (id) must be a number, is ${e}.`);if("number"!=typeof r)throw new Error(`Therapy: Constructor argument priorityOrder must be a number, is ${r}.`);if("string"!=typeof n)throw new Error(`Therapy: Constructor argument priorityName must be a string, is ${n}.`);this.id=e,this.recommendedAntibiotics=t,this.priority={order:r,name:n},this.markdownText=i}containsAntibiotic(e){return!!this.recommendedAntibiotics.find(t=>t.antibiotic===e)}setDiagnosisId(e){this.diagnosisId=e}removeDiagnosisId(){delete this.diagnosisId}}const pr=N()("infect:TherapyFetcher");class dr extends U{constructor(e){super(e);const{handleError:t}=e;this.handleError=t,pr("handleError set to %o",this.handleError)}handleData(e){e.forEach(e=>{pr("Create model for therapy %o",e);const[t,r,n]=this.dependentStores,i=t.getById(e.id_therapyPriority),o=r.getAsArray().filter(t=>t.id_therapy===e.id).map(t=>n.getById(t.id_compound)?{antibiotic:n.getById(t.id_compound),markdownText:t.markdownText}:(pr("All antibiotics are",n.getAsArray()),void this.handleError({severity:G.warning,message:`Antibiotic ${t.id_compound} could not be found. The results displayed to you will therefore not be complete for therapy ${e.id}.`}))).filter(e=>void 0!==e);pr("Priority is %o, recommended antibiotics are %o",i,o);const a=new fr(e.id,o,i.priority,i.name,e.markdownText);a.setDiagnosisId(e.id_diagnosis),this.store.add(a)})}}class hr{constructor(e,t=""){if("number"!=typeof e)throw new Error(`DiagnosisClass: First constructor argument (id) must be a number, is ${e}.`);if("string"!=typeof t)throw new Error(`DiagnosisClass: Second constructor argument (name) must be a string, is ${t}.`);this.id=e,this.name=t}}class mr extends U{handleData(e){e.forEach(e=>{this.store.add(new hr(e.id,e.name))})}}var gr,yr;function vr(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const br=N()("infect:GuidelineStore");let wr=(yr=vr((gr=class extends L{constructor(...e){super(...e),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"selectedGuideline",yr,this)}add(e,...t){br("Add guideline %o",e),super.add(e,...t),this.selectedGuideline||(this.selectedGuideline=e)}selectGuideline(e){this.selectedGuideline=e}getSelectedDiagnosis(){return this.selectedGuideline&&this.selectedGuideline.selectedDiagnosis}search(e){return function(e,t){if(""===t)return[];const r=function(e){return e.map(e=>e.diagnoses.map(t=>["",...t.synonyms].map(r=>({name:t.name,synonym:r,diagnosis:t,guideline:e})))).flat(3)}(e);return new Ot.a(r,{shouldSort:!0,threshold:.3,tokenize:!0,minMatchCharLength:1,keys:[{name:"name",weight:.7},{name:"synonym",weight:.3}]}).search(t).reduce((e,t)=>e.find(e=>e.diagnosis===t.diagnosis)?e:[...e,t],[])}(this.getAsArray(),e)}}).prototype,"selectedGuideline",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:null}),vr(gr.prototype,"add",[T.k],Object.getOwnPropertyDescriptor(gr.prototype,"add"),gr.prototype),vr(gr.prototype,"selectGuideline",[T.k],Object.getOwnPropertyDescriptor(gr.prototype,"selectGuideline"),gr.prototype),gr);var xr,_r;let Sr=(_r=function(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}((xr=class extends R{constructor(e){super(),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"data",_r,this),this.handleException=e}set(e,t){Array.isArray(t)?Object.values(W).includes(e)?this.data[e]=t:this.handleException({severity:G.warning,message:`RDACounterStore: RDA counter field ${e} is not known; use any of ${Object.values(W).join(", ")} instead.`}):this.handleException({severity:G.warning,message:`RDACounterStore: RDA counter data for field ${e} should be an array, is ${JSON.stringify(t)} instead.`})}hasItem(e,t){return!(!this.data[e]||!this.data[e].includes(t))}}).prototype,"data",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return new Map}}),xr);const Er=N()("infect:RDACounterFetcher.js");class kr extends U{constructor(e){const{dataVersionStatusIdentifiers:t}=e,r=t&&t.length?`${e.url}?filter=${JSON.stringify({dataVersionStatusIdentifier:t})}`:e.url;super({...e,url:r});const{handleError:n}=e;this.handleException=n}handleData(e){e&&"object"==typeof e&&e.constructor===Object?Object.entries(e).forEach(([e,t])=>{Object.values(W).includes(e)?(Er("Pass data %o/%o to store",e,t),this.store.set(e,t)):Er("Ignore %o/%o, is not part of valid types %o",e,t,W)}):this.handleException({severity:G.warning,message:`RDACounterStore: Expected object parameter, got ${JSON.stringify(e)} instead.`})}}class Cr extends U{constructor(e){super(e),this.handleException=e.handleException}handleData(e){try{this.store.setData(e)}catch(e){this.handleException({severity:G.warning,message:e.message})}}}var Or,Ar,Tr;function Pr(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}function jr(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Fr=(Ar=jr((Or=class extends R{constructor(...e){super(...e),Pr(this,"featureFlags",Ar,this),Pr(this,"config",Tr,this)}setData(e){if(!e||"object"!=typeof e||null===e||e.constructor!==Object)throw new Error("TenantConfigStore: Data passed in is invalid; expected object with properties configuration and/or featureFlags but got "+JSON.stringify(e));e.featureFlags&&this.validateAndSetFeatureFlags(e),e.configuration&&this.validateAndSetConfig(e)}validateAndSetFeatureFlags(e){if(!Array.isArray(e.featureFlags))throw new Error("TenantConfigStore: Property futureFlags on tenantConfig must be an array, is "+JSON.stringify(e.featureFlags));for(const t of e.featureFlags){if("string"!=typeof t.identifier||"boolean"!=typeof t.enabled)throw new Error("TenantConfigStore: Expected properties identifier (string) and enabled(boolean) on featureFlag, but got "+JSON.stringify(t));this.featureFlags.set(t.identifier,t.enabled)}}validateAndSetConfig(e){if(!Array.isArray(e.configuration))throw new Error("TenantConfigStore: Expected data.configuration to be an array, but is "+JSON.stringify(e.configuration));for(const t of e.configuration){if("object"!=typeof t||null===t||t.constructor!==Object||"string"!=typeof t.identifier||!Object.prototype.hasOwnProperty.call(t,"config"))throw new Error(`TenantConfigStore: Every configuration must be an object with properties identifier (string) and config; you passed ${JSON.stringify(t)} instead`);this.config.set(t.identifier,t.config)}}getConfig(e){return this.config.get(e)}hasFeature(e){return this.featureFlags.get(e)||!1}}).prototype,"featureFlags",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return new Map}}),Tr=jr(Or.prototype,"config",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return new Map}}),jr(Or.prototype,"validateAndSetFeatureFlags",[T.k],Object.getOwnPropertyDescriptor(Or.prototype,"validateAndSetFeatureFlags"),Or.prototype),jr(Or.prototype,"validateAndSetConfig",[T.k],Object.getOwnPropertyDescriptor(Or.prototype,"validateAndSetConfig"),Or.prototype),Or);const Nr=N()("infect:GuidelineSelectedFiltersBridge");class zr{constructor(e,t,r){this.guidelineStore=e,this.selectedFilters=t,this.filterValues=r}getFilterValuesRelatedToSelectedDiagnosis(){const e=this.guidelineStore.getSelectedDiagnosis();if(!e)return[];const t=e.inducingBacteria.map(({name:e})=>e),r=e.therapies.reduce((e,t)=>[...e,...t.recommendedAntibiotics],[]).map(({antibiotic:e})=>e.name);Nr("Diagnosis is %o, names of antibiotics are %o and of bacteria %o",e,r,t);const n=this.filterValues.getValuesForProperty(_t.bacterium,"name").filter(e=>t.includes(e.value)),i=this.filterValues.getValuesForProperty(_t.antibiotic,"name").filter(e=>r.includes(e.value));return Nr("Matching filters are bacteria %o and antibiotics %o",n,i),[...n,...i]}selectFiltersRelatedToSelectedDiagnosis(){const e=this.getFilterValuesRelatedToSelectedDiagnosis();Object(T.H)(()=>{e.forEach(e=>{this.selectedFilters.addFilter(e)})})}areAllDiagnosisRelatedFiltersSelected(){return this.getFilterValuesRelatedToSelectedDiagnosis().every(e=>this.selectedFilters.isSelected(e))}}var Dr=async(e,t,r)=>{e.values.forEach(async n=>{const i=[ve.mic,ve.discDiffusion].includes(n.type),o=Object.keys(n.quantitativeData).length>0;if(!i||o)return;const a=await(async(e,t,r,n)=>{const i={...n,compoundSubstanceIds:[e.antibiotic.id],microorganismIds:[e.bacterium.id]},o=`${r("rda","data")}?subRoutines=["${{mic:"MICPercentileSubRoutine",discDiffusion:"DiscDiffusionPercentile"}[t.type.identifier]}"]&filter=${JSON.stringify(i)}`,a=await B(o,{cache:"no-store",credentials:"include"});if(200!==a.status)throw new Error(`fetchQuantitativeData: Status ${a.status} is invalid.`);const s={mic:"MICPercentile90",discDiffusion:"discDiffusionPercentile90"}[t.type.identifier];if(!(a.data&&a.data.values&&1===a.data.values.length&&a.data.values[0]&&a.data.values[0][s]))throw new Error(`fetchQuantitativeData: Expected response to have data.values[0].${s}, is ${JSON.stringify(a)} instead.`);return a.data.values[0][s]})(e,n,t,r);n.setQuantitativeData(a)})};var Rr,Ir,Mr=(e,t,r,n)=>{Object(T.E)(()=>[r.filterHeaders],()=>{"resistance"===n.contentType&&n.setContent(void 0)}),Object(T.l)(()=>{r.filterHeaders;const{activeResistance:n}=e;n&&n.resistance&&setTimeout(()=>Dr(n.resistance,t,r.filterHeaders),400)})};const Lr=N()("infect:App");let Vr=(Ir=function(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}((Rr=class{constructor(e){!function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"views",Ir,this),this.bacteria=new ne,this.antibiotics=new V,this.guidelines=new wr,this.substanceClasses=new K,this.resistances=new me([],e=>`${e.bacterium.id}/${e.antibiotic.id}`),this.filterValues=new Tt,this.tenantConfig=new Fr,this.selectedFilters=new Vt,this.offsetFilters=new Ft,this.mostUsedFilters=new Ht(this.selectedFilters,this.filterValues),this.notificationCenter=new or,this.ageGroupStore=new L,this.rdaCounterStore=new Sr(this.notificationCenter.handle.bind(this.notificationCenter)),this.guidelineRelatedFilters=new zr(this.guidelines,this.selectedFilters,this.filterValues),this._config=e,this._setupFilterValues(),this._setupOffsetFilters(),this.views.matrix.setSelectedFilters(this.selectedFilters),this.views.matrix.setOffsetFilters(this.offsetFilters),this.views.matrix.setupDataWatchers(this.antibiotics,this.bacteria,this.resistances)}initialize(){var e,t,r;e=this.guidelines,t=this.views.drawer,r=this.notificationCenter,Object(T.E)(()=>e.selectedGuideline&&e.selectedGuideline.selectedDiagnosis,n=>{ar("Selected diagnosis changed to %o",n);try{n?t.setContent(e.selectedGuideline):t.setContent(void 0)}catch(e){r.handle(e)}});const n=this._setupFetchers(),i=function(e,t,r){const n=new Kt({url:e("coreData","animals"),store:new L,dependentStores:[r],filterValues:t,rdaCounterType:W.animal,filterType:_t.animal}).getData(),i=new Kt({url:e("coreData","hospitalStatus"),store:new L,dependentStores:[r],filterValues:t,rdaCounterType:W.patientSetting,filterType:_t.hospitalStatus}).getData(),o=new Kt({url:e("coreData","regions"),store:new L,dependentStores:[r],filterValues:t,rdaCounterType:W.region,filterType:_t.region}).getData(),a=new Kt({url:e("coreData","sampleSource"),store:new L,dependentStores:[r],filterValues:t,rdaCounterType:W.sampleSource,filterType:_t.sampleSource}).getData();return Promise.all([n,i,o,a])}(this._config.getURL,this.filterValues,this.rdaCounterStore),o=(a=this.tenantConfig,s=this.filterValues,l=this.ageGroupStore,c=this.notificationCenter.handle.bind(this.notificationCenter),void Object(T.E)(()=>a.status.identifier,e=>{if(e!==z.ready)return;const t=a.getConfig("frontend");t&&t.rda&&t.rda.ageGroups?t.rda.ageGroups.forEach((e,t)=>{const r={...e,id:t};l.add(r),s.addEntity(_t.ageGroup,r)}):c({message:`setupAgeGroups: Age groups missing or invalid on tenant config; expected Array under frontend.rda.ageGroups; frontend property is ${JSON.stringify(t)}, however.`,severity:G.warning})}));var a,s,l,c;return Promise.all([n,i,o]).then(()=>{Lr("INFECT app successfully initialized")},e=>{this.notificationCenter.handle(e)})}_setupFetchers(){const e=new re({url:this._config.getURL("coreData","substanceClasses"),store:this.substanceClasses}).getData();Lr("Fetching data for substanceClasses.");const t=new J({url:this._config.getURL("coreData","antibiotics"),store:this.antibiotics,options:{headers:{select:"substance.*, substance.substanceClass.*"}},dependentStores:[this.substanceClasses,this.rdaCounterStore],handleError:this.notificationCenter.handle.bind(this.notificationCenter)}).getData();Lr("Fetching data for antibiotics.");const r=new he({url:this._config.getURL("coreData","bacteria"),store:this.bacteria,options:{headers:{select:"shape.*"}},dependentStores:[this.rdaCounterStore]}).getData();Lr("Fetching data for bacteria.");const n=new Ce({url:this._config.getURL("rda","data"),store:this.resistances,dependentStores:[this.antibiotics,this.bacteria],handleError:this.notificationCenter.handle.bind(this.notificationCenter)}),i=new qt(n,this.selectedFilters,this.ageGroupStore,this.notificationCenter.handle.bind(this.notificationCenter),this._config.dataVersionStatusIdentifiers);i.setup();const o=n.getDataForFilters(i.filterHeaders);Lr("Fetching data for resistances."),Mr(this.views.matrix,this._config.getURL,i,this.views.drawer);const a=async function(e,t,r,n,i){if(!e||"function"!=typeof e)throw new Error(`setupGuidelines: getURL missing or not a function; is ${JSON.stringify(e)}.`);const o=[],a=new L,s=new mr({url:e("guideline","diagnosisClass"),store:a});o.push(s.getData());const l=new L,c=new U({url:e("guideline","therapyPriorities"),store:l});o.push(c.getData());const u=new L,f=new U({url:e("guideline","therapyCompounds"),store:u});o.push(f.getData());const p=new L,d=new U({url:e("guideline","diagnosisBacteria"),store:p});o.push(d.getData());const h=new L,m=new dr({url:e("guideline","therapies"),store:h,dependentStores:[l,u,n],handleError:i});o.push(m.getData());const g=new L,y=new ur({url:e("guideline","diagnoses"),store:g,dependentStores:[a,p,r,h],handleError:i});o.push(y.getData());const v=new sr({url:e("guideline","guidelines"),store:t,dependentStores:[g]});return o.push(v.getData()),Promise.all(o)}(this._config.getURL,this.guidelines,this.bacteria,this.antibiotics,this.notificationCenter.handle.bind(this.notificationCenter)).catch(e=>{const t="Guidelines could not be fetched from server, but INFECT will work without them. Please contact us if the issue persists. Original error:  "+e.message;this.notificationCenter.handle({severity:G.warning,message:t})}),s=new Cr({url:this._config.getURL("tenant","config"),store:this.tenantConfig,handleException:this.notificationCenter.handle.bind(this.notificationCenter)}).getData(),l=new kr({url:this._config.getURL("rda","counter"),store:this.rdaCounterStore,handleError:this.notificationCenter.handle.bind(this.notificationCenter),dataVersionStatusIdentifiers:this._config.dataVersionStatusIdentifiers}).getData();return Lr("Fetchers setup done."),Promise.all([e,l,t,r,o,a,s])}_setupOffsetFilters(){this.offsetFilters.setFilter("sampleSize","min",20),Object(T.E)(()=>{const e=this.tenantConfig.getConfig("frontend");if(e&&e.userInterface&&"number"==typeof e.userInterface.sampleCountDefaultValue)return e.userInterface.sampleCountDefaultValue},e=>{this.offsetFilters.setFilter("sampleSize","min",e)}),this.offsetFilters.setFilter("susceptibility","min",0)}_setupFilterValues(){[{entityType:_t.antibiotic,config:{name:{translation:"Name",valueTranslations:e=>e},iv:{translation:"Intravenous",valueTranslations:[{value:!0,translation:"Intravenous"},{value:!1,translation:"Not intravenous"}]},po:{translation:"Per Os",valueTranslations:[{value:!0,translation:"Per os"},{value:!1,translation:"Not per 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e=this.props.resistance.xPosition,t=this.props.resistance.yPosition;if(!e||!t)return this._getPreviousPosition();const r=e.left+this.props.matrix.defaultRadius,n=t.top+this.props.matrix.defaultRadius;return this._previousPosition={left:r,top:n},ri("Resistance %o is placed at %d/%d",this,r,n),`translate(${r}, ${n})`}get classModifier(){const e=this.props.resistance.visible;this.transformation;const t=Bn(e,this._wasVisible);return this._wasVisible=e,t}get opacity(){return this.props.resistance.matchesOffsets?1:.2}_handleClick(){const e=this.props.drawerViewModel,t=e.content===this.props.resistance.resistance,{isOpen:r}=e;return t&&r?e.close():t&&!r?e.open():void e.setContent(this.props.resistance.resistance)}render(){return Hr.a.createElement("g",{transform:this.transformation,className:`resistanceMatrix__resistance js-resistance ${this.classModifier} ${this.resistaceTypeClass}`,"data-antibiotic":this.props.resistance.resistance.antibiotic.name,"data-bacterium":this.props.resistance.resistance.bacterium.name,onMouseEnter:this._handleMouseEnter,onMouseLeave:this._handleMouseLeave,onClick:this._handleClick},Hr.a.createElement("g",{style:{opacity:this.opacity}},Hr.a.createElement("circle",{r:this.props.resistance.radius,fill:this.props.resistance.backgroundColor,className:"resistanceMatrix__resistanceCircle"}),Hr.a.createElement("text",{textAnchor:"middle",fill:this.props.resistance.fontColor,dominantBaseline:"central",className:"resistanceMatrix__resistanceText",dy:Xn("-2","0.35em")},this.props.resistance.displayValue)))}}).prototype,"transformation",[T.m],Object.getOwnPropertyDescriptor(ei.prototype,"transformation"),ei.prototype),ti(ei.prototype,"classModifier",[T.m],Object.getOwnPropertyDescriptor(ei.prototype,"classModifier"),ei.prototype),ti(ei.prototype,"opacity",[T.m],Object.getOwnPropertyDescriptor(ei.prototype,"opacity"),ei.prototype),Zn=ei))||Zn;const ai=j()("infect:ResistanceDetailComponent");var si,li,ci=Mn((function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((ii=class extends Hr.a.Component{constructor(){super(),this._radius=40}get transformation(){ai("Get transformation for resistanceDetail");const e=this.props.resistance.yPosition.top+this.props.defaultRadius,t=Math.max(e,this._radius);return`translate(${this.props.resistance.xPosition.left+this.props.defaultRadius}, \n\t\t\t${t})`}render(){return Hr.a.createElement("g",{transform:this.transformation,className:"resistanceMatrix__resistanceDetail"},Hr.a.createElement("defs",null,Hr.a.createElement("filter",{id:"resistanceDetailBlur",x:"-50%",y:"-50%",width:"200%",height:"200%"},Hr.a.createElement("feGaussianBlur",{in:"SourceGraphic",stdDeviation:"5"}))),Hr.a.createElement("circle",{r:this._radius,filter:"url(#resistanceDetailBlur)",className:"resistanceMatrix__resistanceDetailCircleShadow"}),Hr.a.createElement("circle",{r:this._radius,fill:this.props.resistance.backgroundColor,className:"resistanceMatrix__resistanceDetailCircle"}),Hr.a.createElement("text",{fill:this.props.resistance.fontColor,dominantBaseline:"alphabetical",textAnchor:"middle",dy:Xn("-0.4em","-0.4em"),dx:"2",className:"resistanceMatrix__resistanceDetailValueText"},this.props.resistance.displayValue,"qualitative"===this.props.resistance.mostPreciseResistanceTypeIdentifier&&Hr.a.createElement("tspan",{className:"resistanceMatrix__resistanceDetailValuePercentSign"},"%")),Hr.a.createElement("text",{fill:this.props.resistance.fontColor,dominantBaseline:"hanging",textAnchor:"middle",dy:Xn("-0.4em","0.5em"),className:"resistanceMatrix__resistanceDetailSampleSizeText"},"qualitative"===this.props.resistance.mostPreciseResistanceTypeIdentifier&&void 0!==this.props.resistance.mostPreciseValue.confidenceInterval&&Hr.a.createElement(Hr.a.Fragment,null,"CI ",Math.round(100*(1-this.props.resistance.mostPreciseValue.confidenceInterval[1])),"–",Math.round(100*(1-this.props.resistance.mostPreciseValue.confidenceInterval[0])),"%"),"mic"===this.props.resistance.mostPreciseResistanceTypeIdentifier&&"MIC90","discDiffusion"===this.props.resistance.mostPreciseResistanceTypeIdentifier&&"Disc Diff."),Hr.a.createElement("text",{fill:this.props.resistance.fontColor,dominantBaseline:"hanging",textAnchor:"middle",dy:Xn("0.6em","1.5em"),className:"resistanceMatrix__resistanceDetailSampleSizeText"},"N=",(this.props.resistance.mostPreciseValue.sampleSize+"").split("").reverse().map((e,t)=>t%3==0&&t>0?e+"'":e).reverse().join("")))}}).prototype,"transformation",[T.m],Object.getOwnPropertyDescriptor(ii.prototype,"transformation"),ii.prototype),ni=ii))||ni;function ui(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let fi=Mn((ui((li=class extends Hr.a.Component{constructor(){super(),this._lineWeight=1,this._wasVisible=!0}get classModifier(){this.transformation;const e=Bn(this.visible,this._wasVisible);return this._wasVisible=this.visible,e}_getPreviousPosition(){return`translate(${this._previousPosition&&this._previousPosition.left||0}, ${this._previousPosition&&this._previousPosition.top||0})`}get transformation(){return this.visible?(this._previousPosition={left:this.leftPosition,top:0},`translate(${this.leftPosition}, 0)`):this._getPreviousPosition()}get leftPosition(){return this.props.substanceClass.xPosition&&this.props.substanceClass.xPosition.left||0}get visible(){return!!this.props.substanceClass.xPosition&&void 0!==this.props.substanceClass.xPosition.left}render(){return Hr.a.createElement("rect",{width:this._lineWeight,height:this.props.height||0,fill:this.props.substanceClass.lineColor,transform:this.transformation,className:"resistanceMatrix__substanceClassLine resistanceMatrix__substanceClassLine--left-body "+this.classModifier})}}).prototype,"classModifier",[T.m],Object.getOwnPropertyDescriptor(li.prototype,"classModifier"),li.prototype),ui(li.prototype,"transformation",[T.m],Object.getOwnPropertyDescriptor(li.prototype,"transformation"),li.prototype),ui(li.prototype,"leftPosition",[T.m],Object.getOwnPropertyDescriptor(li.prototype,"leftPosition"),li.prototype),ui(li.prototype,"visible",[T.m],Object.getOwnPropertyDescriptor(li.prototype,"visible"),li.prototype),si=li))||si;var pi,di,hi;function mi(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const gi=j()("infect:MatrixComponent");let yi=Mn((di=class extends Hr.a.Component{constructor(...e){super(...e),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"svg",hi,this),this._setSVG=e=>{gi("SVG set to %o",e),this._svg=e,this._setDimensions()}}componentDidMount(){this._setupResizeListener()}_setDimensions(){if(!this._svg)return;const e=this._svg.getBoundingClientRect();gi("Set dimensions to %o",e),this.props.matrix.setDimensions(e)}_setupResizeListener(){window.addEventListener("resize",()=>this._setDimensions())}get mainMatrixTransformation(){return`translate(${this.props.matrix.bacteriumLabelColumnWidth+this.props.matrix.spaceBetweenGroups}, 0)`}render(){return Hr.a.createElement("div",null,Hr.a.createElement("svg",{ref:this._setSVG,width:"100%",style:{height:this.props.matrix.visibleBacteriaHeight+this.props.matrix.spaceBetweenGroups,top:this.props.matrix.headerHeight},className:"resistanceMatrix__body "+(this.props.selectedFilters.filterChanges>0?"-with-transitions":"-no-transitions")},this.props.matrix.defaultRadius&&Hr.a.createElement("g",null,this.props.matrix.sortedAntibiotics.map(e=>Hr.a.createElement(Yn,{key:e.antibiotic.id,antibiotic:e,matrix:this.props.matrix,guidelines:this.props.guidelines}))),this.props.matrix.defaultRadius&&Hr.a.createElement("g",{transform:this.mainMatrixTransformation},this.props.matrix.substanceClasses.map(e=>Hr.a.createElement(fi,{key:e.substanceClass.id,substanceClass:e,height:(2*this.props.matrix.defaultRadius+this.props.matrix.space)*this.props.matrix.sortedBacteria.length+this.props.matrix.spaceBetweenGroups}))),this.props.matrix.defaultRadius&&Hr.a.createElement("g",null,this.props.matrix.sortedBacteria.map(e=>Hr.a.createElement(qn,{key:e.bacterium.id,bacterium:e,matrix:this.props.matrix,guidelines:this.props.guidelines}))),Hr.a.createElement("g",{className:"resistanceMatrix__bacteriaLabels"},this.props.matrix.sortedBacteria.map(e=>Hr.a.createElement(Un,{key:e.bacterium.id,bacterium:e,matrix:this.props.matrix,selectedFilters:this.props.selectedFilters,guidelines:this.props.guidelines}))),this.props.matrix.defaultRadius&&Hr.a.createElement("g",{transform:this.mainMatrixTransformation,className:"resistanceMatrix__resistances"},this.props.matrix.resistances.map(e=>Hr.a.createElement(oi,{key:`${e.resistance.antibiotic.id}/${e.resistance.bacterium.id}`,matrix:this.props.matrix,resistance:e,drawerViewModel:this.props.drawerViewModel})),this.props.matrix.activeResistance&&Hr.a.createElement(ci,{resistance:this.props.matrix.activeResistance,defaultRadius:this.props.matrix.defaultRadius}))))}},hi=mi(di.prototype,"svg",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:null}),mi(di.prototype,"mainMatrixTransformation",[T.m],Object.getOwnPropertyDescriptor(di.prototype,"mainMatrixTransformation"),di.prototype),pi=di))||pi;var vi,bi,wi,xi;function _i(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}function Si(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const Ei=j()("infect:SubstanceClassComponent");let ki=Mn((bi=class extends Hr.a.Component{constructor(){super(),_i(this,"_isHovered",wi,this),_i(this,"_afterHovered",xi,this),this._lineWeight=1,this._wasVisible=!0}componentDidMount(){this._measureHeight(),window.addEventListener("resize",()=>this._measureHeight())}_getPreviousTransformation(){return`translate(${this._previousPosition&&this._previousPosition.left||0}, ${this._previousPosition&&this._previousPosition.top||0})`}get topTransformation(){const e=this.props.substanceClass.substanceClass.getParentSubstanceClasses().length;return this.props.matrix.antibioticLabelRowHeight+(this.props.matrix.maxAmountOfSubstanceClassHierarchies-e-1)*(this.props.matrix.greatestSubstanceClassLabelHeight||0)+this.props.matrix.space}get transformation(){if(!this.visible)return this._getPreviousTransformation();const e=this.topTransformation,{left:t}=this.props.substanceClass.xPosition;return this._previousPosition={left:t,top:e},Ei("Position for %o is %d/%d",this.props.substanceClass,t,e),`translate(${t}, ${e})`}_setTextElement(e){e&&(this._textElement=e)}_measureHeight(){if(!this._textElement)return void Ei("SubstanceClass: Element not set, cannot get height.");const e=window.getComputedStyle(this._textElement);let t=Math.ceil(parseFloat(e.fontSize));t+=this._lineWeight+2*this.props.matrix.space,this.props.matrix.setSubstanceClassHeight(this.props.substanceClass,t)}get _labelWidth(){const e=this.props.substanceClass.xPosition;if(!e||Number.isNaN(e.right)||Number.isNaN(e.left))return this._previousLabelWidth||0;const t=e.right-e.left,r=this._afterHovered?Math.max(t,this._getApproximateTextWidth())+2*this.props.matrix.space:t;return this._previousLabelWidth=r,r}get headerLineHeight(){return this.props.matrix.greatestSubstanceClassLabelHeight}get visible(){const e=this.props.substanceClass.xPosition&&this.props.substanceClass.xPosition.left;return!Number.isNaN(e)&&void 0!==e}get classModifier(){this.transformation;const e=Bn(this.visible,this._wasVisible);return this._wasVisible=this.visible,e}_getApproximateTextWidth(){return this._textElement.getBBox().width}_updateAfterHoveredState(e){this._afterHovered=e}_updateHoveredState(e){this._isHovered=e,setTimeout(()=>this._updateAfterHoveredState(e),0)}_getFillColor(){const e=this.props.substanceClass.substanceClass.color;if(!e)return"rgb(255, 255, 255)";const t=Ie()({r:e.r,g:e.g,b:e.b});return t.brighten(40).desaturate(60),t}_handleSubstanceClassClick(){const e=this.props.filters.getValuesForProperty("substanceClass","name").find(e=>e.value===this.props.substanceClass.substanceClass.name);Ei("Clicked on substance class; corresponding filter is %o",e),this.props.selectedFilters.isSelected(e)?this.props.selectedFilters.removeFilter(e):this.props.selectedFilters.addFilter(e)}render(){return Hr.a.createElement("g",{transform:this.transformation,className:"resistanceMatrix__substanceClassLabel js-substance-class "+this.classModifier,onMouseEnter:()=>this._updateHoveredState(!0),onMouseLeave:()=>this._updateHoveredState(!1),onClick:()=>this._handleSubstanceClassClick()},Hr.a.createElement("defs",null,Hr.a.createElement("path",{id:`substance-class-${this.props.substanceClass.substanceClass.id}-path`,d:`M 0 0 L ${this._labelWidth-5} 0`})),Hr.a.createElement("rect",{width:this._labelWidth,height:this.headerLineHeight||0,fill:this._getFillColor()}),Hr.a.createElement("rect",{width:this._labelWidth,height:this._lineWeight,fill:this.props.substanceClass.lineColor,className:"resistanceMatrix__substanceClassLine resistanceMatrix__substanceClassLine--top"}),Hr.a.createElement("rect",{width:this._lineWeight,height:this.headerLineHeight||0,fill:this.props.substanceClass.lineColor,className:"resistanceMatrix__substanceClassLine resistanceMatrix__substanceClassLine--left-header"}),Hr.a.createElement("text",{className:"resistanceMatrix__substanceClassLabelText",dominantBaseline:"hanging",dy:Xn("-2","0.8em"),transform:`translate(${this.props.matrix.space}, ${this.props.matrix.space})`,ref:e=>this._setTextElement(e)},!this._isHovered&&Hr.a.createElement("textPath",{xlinkHref:`#substance-class-${this.props.substanceClass.substanceClass.id}-path`,dominantBaseline:"hanging"},this.props.substanceClass.substanceClass.name),this._isHovered&&this.props.substanceClass.substanceClass.name))}},wi=Si(bi.prototype,"_isHovered",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return!1}}),xi=Si(bi.prototype,"_afterHovered",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return!1}}),Si(bi.prototype,"topTransformation",[T.m],Object.getOwnPropertyDescriptor(bi.prototype,"topTransformation"),bi.prototype),Si(bi.prototype,"transformation",[T.m],Object.getOwnPropertyDescriptor(bi.prototype,"transformation"),bi.prototype),Si(bi.prototype,"_labelWidth",[T.m],Object.getOwnPropertyDescriptor(bi.prototype,"_labelWidth"),bi.prototype),Si(bi.prototype,"headerLineHeight",[T.m],Object.getOwnPropertyDescriptor(bi.prototype,"headerLineHeight"),bi.prototype),Si(bi.prototype,"visible",[T.m],Object.getOwnPropertyDescriptor(bi.prototype,"visible"),bi.prototype),Si(bi.prototype,"classModifier",[T.m],Object.getOwnPropertyDescriptor(bi.prototype,"classModifier"),bi.prototype),Si(bi.prototype,"_updateAfterHoveredState",[T.k],Object.getOwnPropertyDescriptor(bi.prototype,"_updateAfterHoveredState"),bi.prototype),Si(bi.prototype,"_updateHoveredState",[T.k],Object.getOwnPropertyDescriptor(bi.prototype,"_updateHoveredState"),bi.prototype),vi=bi))||vi;var Ci,Oi;function Ai(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Ti=Mn((Ai((Oi=class extends Hr.a.Component{constructor(...e){super(...e),this.guidelineCircleRadius=10,this.spaceBetweenGuidelineCircles=4,this._wasVisible=!0,this._setTextElement=e=>{e&&(this._textElement=e,this._setDimensions())}}componentDidMount(){this._setupResizeListener()}_setDimensions(){if(!this._textElement)return;const e=Math.ceil(this._textElement.getBBox().width);this.props.antibiotic.setDimensions(e,e)}get transformation(){if(!this.props.matrix.greatestSubstanceClassLabelHeight)return"translate(0, 0) rotate(-75)";if(!this.props.antibiotic.visible)return`translate(${this._previousPosition.left||0}, ${this._previousPosition.top||0}) rotate(-75)`;const e=this.props.matrix.xPositions.get(this.props.antibiotic),t=(e?e.left:0)+1.2*this._textElement.getBBox().height,r=this.props.matrix.maxAmountOfSubstanceClassHierarchies-this.props.antibiotic.antibiotic.getSubstanceClasses().length,n=(this.props.matrix.antibioticLabelRowHeight||0)+r*(this.props.matrix.greatestSubstanceClassLabelHeight||0);return this._previousPosition={left:t,top:n},`translate(${t}, ${n}) rotate(-75)`}get classModifier(){this.transformation;const e=Bn(this.props.antibiotic.visible,this._wasVisible);return this._wasVisible=this.props.antibiotic.visible,e}_setupResizeListener(){window.addEventListener("resize",()=>this._setDimensions())}get highlightClass(){const{activeResistance:e}=this.props.matrix;return e&&this.props.antibiotic.antibiotic===e.resistance.antibiotic?"highlight":""}get guidelineClass(){return this.therapiesForSelectedDiagnosisAndAntibiotic.length>0?"containsGuidelineData":""}get therapiesForSelectedDiagnosisAndAntibiotic(){const e=this.props.guidelines&&this.props.guidelines.selectedGuideline&&this.props.guidelines.selectedGuideline.selectedDiagnosis;return e?e.therapies.filter(e=>e.containsAntibiotic(this.props.antibiotic.antibiotic)).map(e=>e.priority.order):[]}get totalGuidelineCircleWidth(){return 2*this.guidelineCircleRadius+this.spaceBetweenGuidelineCircles}render(){return Hr.a.createElement("g",{transform:this.transformation,style:{visibility:this.props.matrix.defaultRadius?"visible":"hidden"},className:"resistanceMatrix__antibioticLabel "+this.classModifier},this.therapiesForSelectedDiagnosisAndAntibiotic&&this.therapiesForSelectedDiagnosisAndAntibiotic.map((e,t)=>Hr.a.createElement("g",{key:e},Hr.a.createElement("circle",{r:this.guidelineCircleRadius,cx:t*this.totalGuidelineCircleWidth+9,cy:"-13",className:"resistanceMatrix__antibioticLabelGuidelinePriorityCircle"}),Hr.a.createElement("text",{dy:"-9",dx:5+this.totalGuidelineCircleWidth*t,className:"resistanceMatrix__antibioticLabelGuidelinePriorityText"},e))),Hr.a.createElement("text",{dy:"-9",ref:this._setTextElement,dx:this.therapiesForSelectedDiagnosisAndAntibiotic.length*this.totalGuidelineCircleWidth,className:`resistanceMatrix__antibioticLabelText ${this.highlightClass} ${this.guidelineClass}`},this.props.antibiotic.antibiotic.name))}}).prototype,"transformation",[T.m],Object.getOwnPropertyDescriptor(Oi.prototype,"transformation"),Oi.prototype),Ai(Oi.prototype,"classModifier",[T.m],Object.getOwnPropertyDescriptor(Oi.prototype,"classModifier"),Oi.prototype),Ai(Oi.prototype,"highlightClass",[T.m],Object.getOwnPropertyDescriptor(Oi.prototype,"highlightClass"),Oi.prototype),Ai(Oi.prototype,"guidelineClass",[T.m],Object.getOwnPropertyDescriptor(Oi.prototype,"guidelineClass"),Oi.prototype),Ai(Oi.prototype,"therapiesForSelectedDiagnosisAndAntibiotic",[T.m],Object.getOwnPropertyDescriptor(Oi.prototype,"therapiesForSelectedDiagnosisAndAntibiotic"),Oi.prototype),Ci=Oi))||Ci;var Pi,ji,Fi;function Ni(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let zi=Mn((ji=class extends Hr.a.Component{constructor(...e){super(...e),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"_leftScrollPosition",Fi,this)}componentDidMount(){const e=document.querySelector(".resistanceMatrix");e.addEventListener("scroll",()=>{this._updateScrollLeftPosition(e.scrollLeft)})}_updateScrollLeftPosition(e){this._leftScrollPosition=e}get headerTransformation(){return`translate(${this.props.matrix.bacteriumLabelColumnWidth+this.props.matrix.spaceBetweenGroups}, 0)`}get headerScrollTransformation(){return`translate(${-1*this._leftScrollPosition}px, 0)`}get sortedSubstanceClasses(){return this.props.matrix.substanceClasses.slice(0).sort((e,t)=>e.substanceClass.order>t.substanceClass.order?-1:1)}render(){return Hr.a.createElement("svg",{className:"resistanceMatrix__header "+(this.props.selectedFilters.filterChanges>0?"-with-transitions":"-no-transitions"),style:{height:this.props.matrix.headerHeight,transform:this.headerScrollTransformation,visibility:void 0===this.props.matrix.defaultRadius?"hidden":"visible"},width:"100%"},Hr.a.createElement("rect",{x:"0",y:"0",height:"100%",width:"100%",fill:"rgb(255, 255, 255)"}),void 0!==this.props.matrix.bacteriumLabelColumnWidth&&Hr.a.createElement("g",null,Hr.a.createElement("g",{className:"resistanceMatrix__antibioticsLabels",transform:this.headerTransformation},this.props.matrix.sortedAntibiotics.map(e=>Hr.a.createElement(Ti,{key:e.antibiotic.id,antibiotic:e,matrix:this.props.matrix,guidelines:this.props.guidelines}))),void 0!==this.props.matrix.defaultRadius&&Hr.a.createElement("g",{transform:this.headerTransformation},Hr.a.createElement("g",{className:"resistanceMatrix__substanceClassLabes"},this.sortedSubstanceClasses.map(e=>Hr.a.createElement(ki,{key:e.substanceClass.id,substanceClass:e,matrix:this.props.matrix,className:"resistanceMatrix__substanceClassLabel",filters:this.props.filters,selectedFilters:this.props.selectedFilters}))))))}},Fi=Ni(ji.prototype,"_leftScrollPosition",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return 0}}),Ni(ji.prototype,"_updateScrollLeftPosition",[T.k],Object.getOwnPropertyDescriptor(ji.prototype,"_updateScrollLeftPosition"),ji.prototype),Ni(ji.prototype,"headerTransformation",[T.m],Object.getOwnPropertyDescriptor(ji.prototype,"headerTransformation"),ji.prototype),Ni(ji.prototype,"headerScrollTransformation",[T.m],Object.getOwnPropertyDescriptor(ji.prototype,"headerScrollTransformation"),ji.prototype),Ni(ji.prototype,"sortedSubstanceClasses",[T.m],Object.getOwnPropertyDescriptor(ji.prototype,"sortedSubstanceClasses"),ji.prototype),Pi=ji))||Pi;var Di,Ri=r(96);let Ii=Mn(Di=class extends Hr.a.Component{constructor(...e){super(...e),this.state={id:"id_"+Math.random().toString().replace(".","")},this.handleClick=this.handleClick.bind(this)}handleClick(e){"radio"===this.props.inputType&&this.props.checked&&(this.props.onChangeHandler(),e.preventDefault())}render(){return Hr.a.createElement("li",{className:`list-item--${"radio"===this.props.inputType?"radio":"checkbox"} group__list-item ${this.props.shade?"list-item--"+this.props.shade:""}`,onClick:this.handleClick},Hr.a.createElement("input",{type:"radio"===this.props.inputType?"radio":"checkbox",id:this.state.id,value:this.props.value,onChange:this.props.onChangeHandler,checked:this.props.checked,name:this.props.inputName}),Hr.a.createElement("label",{htmlFor:this.state.id,className:"side-label"},this.props.name))}})||Di;function Mi(e){return class extends Hr.a.Component{constructor(){super(),this.translations={bacteria:"Filters for Bacteria",antibiotics:"Filters for Antibiotics",population:"Population and Offsets",mostUsed:"Favorites"}}render(){return Hr.a.createElement("div",{className:"group group--padding group--"+this.props.identifier,id:"js-filter-list-"+this.props.identifier},Hr.a.createElement("h1",null,this.translations[this.props.identifier]),Hr.a.createElement(e,this.props))}}}var Li,Vi;const Bi=j()("infect:AntibioticsFilterList");var $i,Ui=Mi(Mn((function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((Vi=class extends Hr.a.Component{constructor(...e){super(...e),this._handleFilterChange=e=>{Bi("Handle filter change for item %o",e);this.props.selectedFilters.filters.indexOf(e)>-1?this.props.selectedFilters.removeFilter(e):this.props.selectedFilters.addFilter(e)},this._renderSubstanceClassFilters=e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,value:e.niceValue,checked:this.props.selectedFilters.isSelected(e),onChangeHandler:()=>this._handleFilterChange(e)})}_sortByProperty(e){return(t,r)=>t[e]<r[e]?-1:1}_handleNameDropdownFilterChange(e){const t=this._getNamesBySelection()[e];this._handleFilterChange(t)}_isChecked(e){return Object(Ri.a)(e=>this.props.selectedFilters.filters.indexOf(e)>-1)(e)}_getNamesBySelection(e){return this.props.filterValues.getValuesForProperty("antibiotic","name").sort(this._sortByProperty("niceValue")).filter(t=>{const r=this.props.selectedFilters.isSelected(t);return e?r:!r})}_isApplicationChecked(e){const{isFilterSelected:t}=this._getFilterForApplication(e);return t}_getFilterForApplication(e){const t="perOs"===e?"po":"iv",r=this.props.filterValues.getValuesForProperty("antibiotic",t).find(e=>!0===e.value);return{isFilterSelected:this.props.selectedFilters.isSelected(r),filter:r}}_handleApplicationFilterChange(e){const{filter:t,isFilterSelected:r}=this._getFilterForApplication(e);Bi("Filter for %s is %o, selected %o",e,t,r),this.props.selectedFilters.toggleFilter(t)}get _sortedSubstanceClassFilters(){return this.props.filterValues.getValuesForProperty("substanceClass","name").sort(this._sortByProperty("niceValue"))}render(){return Bi("Render."),Hr.a.createElement("div",{id:"antibiotics-filters"},Hr.a.createElement("h3",{className:"gray margin-top"},"Name"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this._getNamesBySelection(!0).map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,value:e.niceValue,checked:this.props.selectedFilters.isSelected(e),onChangeHandler:()=>this._handleFilterChange(e)}))),Hr.a.createElement("select",{className:"select",onChange:e=>this._handleNameDropdownFilterChange(e.target.value)},Hr.a.createElement("option",null,"Please choose …"),this._getNamesBySelection().map((e,t)=>Hr.a.createElement("option",{key:e.value,value:t},e.niceValue)),";"),Hr.a.createElement("h3",{className:"gray margin-top"},"Substance Class"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this._sortedSubstanceClassFilters.map(this._renderSubstanceClassFilters)),Hr.a.createElement("h3",{className:"gray margin-top"},"Application"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},Hr.a.createElement(Ii,{name:"Per Os",value:"perOs",checked:this._isApplicationChecked("perOs"),onChangeHandler:()=>this._handleApplicationFilterChange("perOs")}),Hr.a.createElement(Ii,{name:"Intravenous",value:"intravenous",checked:this._isApplicationChecked("intravenous"),onChangeHandler:()=>this._handleApplicationFilterChange("intravenous")})))}}).prototype,"_sortedSubstanceClassFilters",[T.m],Object.getOwnPropertyDescriptor(Vi.prototype,"_sortedSubstanceClassFilters"),Vi.prototype),Li=Vi))||Li);const Hi=j()("infect:BacteriaFilterList");var Gi,Wi,qi=Mi(Mn($i=class extends Hr.a.Component{constructor(...e){super(...e),this._handleFilterChange=e=>{Hi("Handle filter change for item %o",e),this.props.selectedFilters.toggleFilter(e)}}_sortByProperty(e){return(t,r)=>t[e]<r[e]?-1:1}_handleNameDropdownFilterChange(e){const t=this._getNamesBySelection()[e];this._handleFilterChange(t)}_isChecked(e){return Object(Ri.a)(e=>this.props.selectedFilters.filters.indexOf(e)>-1)(e)}_getNamesBySelection(e){return this.props.filterValues.getValuesForProperty("bacterium","name").sort(this._sortByProperty("niceValue")).filter(t=>{const r=this.props.selectedFilters.isSelected(t);return e?r:!r})}_isMetabolismChecked(e){const{isFilterSelected:t}=this._getFilterForMetabolism(e);return t}_getFilterForMetabolism(e){const t=this.props.filterValues.getValuesForProperty("bacterium",e).find(e=>!0===e.value);return{isFilterSelected:this.props.selectedFilters.isSelected(t),filter:t}}_handleMetabolismChange(e){const{filter:t,isFilterSelected:r}=this._getFilterForMetabolism(e);Hi("Filter for %s is %o, selected %o",e,t,r),this.props.selectedFilters.toggleFilter(t)}render(){return Hr.a.createElement("div",{id:"bacteria-filters"},Hr.a.createElement("h3",{className:"gray margin-top"},"Name"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this._getNamesBySelection(!0).map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,value:e.niceValue,checked:this.props.selectedFilters.isSelected(e),onChangeHandler:t=>this._handleFilterChange(e)}))),Hr.a.createElement("select",{className:"select",onChange:e=>this._handleNameDropdownFilterChange(e.target.value)},Hr.a.createElement("option",null,"Please choose …"),this._getNamesBySelection().map((e,t)=>Hr.a.createElement("option",{key:e.value,value:t},e.niceValue)),";"),Hr.a.createElement("h3",{className:"gray margin-top"},"Gram"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.props.filterValues.getValuesForProperty("bacterium","gram").map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,value:e.niceValue,checked:this.props.selectedFilters.isSelected(e),onChangeHandler:t=>this._handleFilterChange(e)}))),Hr.a.createElement("h3",{className:"gray margin-top"},"Shape"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.props.filterValues.getValuesForProperty("bacterium","shape").map(e=>{if(e.value)return Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,value:e.niceValue,checked:this.props.selectedFilters.isSelected(e),onChangeHandler:t=>this._handleFilterChange(e)})})),Hr.a.createElement("h3",{className:"gray margin-top"},"Metabolism"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},Hr.a.createElement(Ii,{name:"Aerobic",value:"aerobic",checked:this._isMetabolismChecked("aerobic"),onChangeHandler:e=>this._handleMetabolismChange("aerobic")}),Hr.a.createElement(Ii,{name:"Anaerobic",value:"anaerobic",checked:this._isMetabolismChecked("anaerobic"),onChangeHandler:e=>this._handleMetabolismChange("anaerobic")})))}})||$i);function Ji(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const Ki=j()("infect:OffsetFilters");var Qi,Yi,Xi=Mn((Ji((Wi=class extends Hr.a.Component{constructor(e){super(e),this.updateSampleSizeOffsetFilter=this.updateSampleSizeOffsetFilter.bind(this),this.updateSusceptibilityOffsetFilter=this.updateSusceptibilityOffsetFilter.bind(this)}updateSampleSizeOffsetFilter(e){const{value:t}=e.target;Ki("Set min sampleSize to %d",t),this.props.offsetFilters.setFilter("sampleSize","min",Number(t))}get relativeSampleSizeOffset(){return this.props.offsetFilters.filters.get("sampleSize").min}updateSusceptibilityOffsetFilter(e){const{value:t}=e.target;Ki("Set min susceptibility to %d",t),this.props.offsetFilters.setFilter("susceptibility","min",Number(t)/100)}get relativeSusceptibilityOffset(){return 100*this.props.offsetFilters.filters.get("susceptibility").min}render(){return Hr.a.createElement("div",null,Hr.a.createElement("h3",{className:"gray margin-top"},"Sample Size"," ",Hr.a.createElement("span",{className:"white"},"N ≥ ",this.props.offsetFilters.filters.get("sampleSize").min.toFixed(0))),Hr.a.createElement("div",{className:"slider"},Hr.a.createElement("div",{className:"slider__container"},Hr.a.createElement("div",{className:"slider__container__before"},this.props.offsetMinimumValue),Hr.a.createElement("div",{className:"slider__container__range"},Hr.a.createElement("input",{value:this.relativeSampleSizeOffset,className:"slider__range",type:"range",min:this.props.offsetMinimumValue,max:"1000",onChange:this.updateSampleSizeOffsetFilter})),Hr.a.createElement("div",{className:"slider__container__after"},"≥1000"))),Hr.a.createElement("h3",{className:"gray margin-top"},"Susceptibility"," ",Hr.a.createElement("span",{className:"white"},"≥",this.relativeSusceptibilityOffset.toFixed(0),"%")),Hr.a.createElement("div",{className:"slider"},Hr.a.createElement("div",{className:"slider__container"},Hr.a.createElement("div",{className:"slider__container__before"},"0%"),Hr.a.createElement("div",{className:"slider__container__range"},Hr.a.createElement("input",{value:this.relativeSusceptibilityOffset,className:"slider__range",type:"range",onChange:this.updateSusceptibilityOffsetFilter})),Hr.a.createElement("div",{className:"slider__container__after"},"100%"))))}}).prototype,"relativeSampleSizeOffset",[T.m],Object.getOwnPropertyDescriptor(Wi.prototype,"relativeSampleSizeOffset"),Wi.prototype),Ji(Wi.prototype,"relativeSusceptibilityOffset",[T.m],Object.getOwnPropertyDescriptor(Wi.prototype,"relativeSusceptibilityOffset"),Wi.prototype),Gi=Wi))||Gi;function Zi(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const eo=j()("infect:PopulationFilterList");var to,ro,no=Mi(Mn((Zi((Yi=class extends Hr.a.Component{constructor(e){super(e)}_handleFilterChange(e){eo("Handle filter change for population filter %o",e),this.props.selectedFilters.toggleFilter(e)}handleAnimalFilterChange(e){eo("Handle filter change for population filter %o",e);this.props.selectedFilters.getFiltersByType(_t.animal).filter(t=>t!==e).forEach(e=>this.props.selectedFilters.removeFilter(e)),this.props.selectedFilters.toggleFilter(e)}get offsetMinimumValue(){const e=this.props.tenantConfig.getConfig("rda");if(e)return e.sampleCountFilterLowerThreshold||0}isSelected(e){return this.props.selectedFilters.isSelected(e)}get regionFilters(){return this.props.filterValues.getValuesForProperty(_t.region,"id")}get animalFilters(){return this.props.filterValues.getValuesForProperty(_t.animal,"id")}get sampleSourceFilters(){return this.props.filterValues.getValuesForProperty(_t.sampleSource,"id")}get ageGroupFilters(){const e=this.props.ageGroupStore.getAsArray();return this.props.filterValues.getValuesForProperty(_t.ageGroup,"id").sort((t,r)=>e.find(({id:e})=>e===t.value).order-e.find(({id:e})=>e===r.value).order)}get hospitalStatusFilters(){return this.props.filterValues.getValuesForProperty(_t.hospitalStatus,"id")}get isNoRegionSelected(){return 0===this.props.selectedFilters.getFiltersByType(_t.region).length}render(){return Hr.a.createElement("div",{id:"population-filters"},this.animalFilters.length>1&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h3",{className:"gray margin-top"},"Animal"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.animalFilters.map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,inputName:"animal-name",shade:"bright",value:e.niceValue,checked:this.isSelected(e),inputType:"radio",onChangeHandler:()=>this.handleAnimalFilterChange(e)})))),this.regionFilters.length>1&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h3",{className:"gray margin-top"},"Region"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.regionFilters.map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,inputName:"region-name",value:e.niceValue,checked:this.isSelected(e),onChangeHandler:()=>this._handleFilterChange(e)})))),this.ageGroupFilters.length>1&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h3",{className:"gray margin-top"},"Age Group"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.ageGroupFilters.map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,inputName:"ageGroup-name",value:e.niceValue,checked:this.isSelected(e),onChangeHandler:()=>this._handleFilterChange(e)})))),this.hospitalStatusFilters.length>1&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h3",{className:"gray margin-top"},"Patient Setting"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.hospitalStatusFilters.map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,inputName:"hospitalStatus-name",value:e.niceValue,checked:this.isSelected(e),onChangeHandler:()=>this._handleFilterChange(e)})))),this.sampleSourceFilters.length>1&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h3",{className:"gray margin-top"},"Sample Source"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.sampleSourceFilters.map(e=>Hr.a.createElement(Ii,{key:e.value,name:e.niceValue,inputName:"sampleSource-name",value:e.niceValue,checked:this.isSelected(e),onChangeHandler:()=>this._handleFilterChange(e)})))),Hr.a.createElement(Xi,{identifier:"data",offsetFilters:this.props.offsetFilters,offsetMinimumValue:this.offsetMinimumValue}))}}).prototype,"handleAnimalFilterChange",[T.k],Object.getOwnPropertyDescriptor(Yi.prototype,"handleAnimalFilterChange"),Yi.prototype),Zi(Yi.prototype,"offsetMinimumValue",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"offsetMinimumValue"),Yi.prototype),Zi(Yi.prototype,"regionFilters",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"regionFilters"),Yi.prototype),Zi(Yi.prototype,"animalFilters",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"animalFilters"),Yi.prototype),Zi(Yi.prototype,"sampleSourceFilters",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"sampleSourceFilters"),Yi.prototype),Zi(Yi.prototype,"ageGroupFilters",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"ageGroupFilters"),Yi.prototype),Zi(Yi.prototype,"hospitalStatusFilters",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"hospitalStatusFilters"),Yi.prototype),Zi(Yi.prototype,"isNoRegionSelected",[T.m],Object.getOwnPropertyDescriptor(Yi.prototype,"isNoRegionSelected"),Yi.prototype),Qi=Yi))||Qi);const io=j()("infect:MostUsedFiltersListComponent");var oo,ao=Mi(Mn((function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((ro=class extends Hr.a.Component{constructor(){super(),this._handleFilterChange=e=>{io("Handle filter change for item %o",e),this.props.selectedFilters.toggleFilter(e)},this._previousHeight=0}componentDidMount(){this._scrollElement=document.querySelector(".side-navigation__filters"),this._setScrollPositionBeforeChange(),this._filterElement=document.querySelector("#js-filter-list-mostUsed"),setTimeout(()=>{io("componentDidMount"),this._updateScrollPosition()})}componentWillUpdate(){this._setScrollPositionBeforeChange()}componentDidUpdate(){this._updateScrollPosition()}get mostUsedFilters(){return this.props.mostUsedFilters.mostUsedFilters.sort((e,t)=>e.count>t.count?-1:1).slice(0,10)}_setScrollPositionBeforeChange(){this._scrollPositionBeforeUpdate=this._scrollElement.scrollTop,io("Set _scrollPositionBeforeUpdate to %d",this._scrollPositionBeforeUpdate)}_updateScrollPosition(){let e=this._filterElement.getBoundingClientRect().height;e+=41;const t=e-this._previousHeight;io("New height of mostUsed is %d, diff to previous height %d",e,t);const r=this._scrollElement.scrollTop,n=t+r;io("Current scrollTop is %d, new %d",r,this._scrollPositionBeforeUpdate),r===this._scrollPositionBeforeUpdate&&(this._scrollElement.scrollTop=n),this._previousHeight=e}render(){return Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.mostUsedFilters.map(e=>Hr.a.createElement(Ii,{key:e.filter.property.entityType+"-"+e.filter.property.name+"-"+e.filter.value,name:e.filter.niceValue,value:e.filter.niceValue,checked:this.props.selectedFilters.isSelected(e.filter),onChangeHandler:()=>this._handleFilterChange(e.filter)})))}}).prototype,"mostUsedFilters",[T.m],Object.getOwnPropertyDescriptor(ro.prototype,"mostUsedFilters"),ro.prototype),to=ro))||to);const so=j()("infect:GuidelinesFilterList");let lo=Mn(oo=class extends Hr.a.Component{constructor(...e){super(...e),this.selectDiagnosis=this.selectDiagnosis.bind(this)}selectDiagnosis(e){so("Update selected diagnosis to %o",e);const{selectedGuideline:t}=this.props.guidelines;t.selectedDiagnosis===e?t.selectDiagnosis():t.selectDiagnosis(e)}render(){return this.props.guidelines&&this.props.guidelines.selectedGuideline?Hr.a.createElement("div",{className:"group group--padding group--"+this.props.identifier,id:"js-filter-list-"+this.props.identifier},Hr.a.createElement("h1",null,this.props.guidelines.selectedGuideline.name),Hr.a.createElement("h3",{className:"black margin-top"},"Empirical Therapies"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.props.guidelines.selectedGuideline.diagnoses.sort((e,t)=>e.name<t.name?-1:1).filter(e=>"Specific Therapies"!==e.diagnosisClass.name).map(e=>Hr.a.createElement(Ii,{key:e.id,inputName:"diagnosis",name:e.name,inputType:"radio",checked:e===this.props.guidelines.selectedGuideline.selectedDiagnosis,onChangeHandler:()=>this.selectDiagnosis(e)}))),Hr.a.createElement("h3",{className:"black margin-top"},"Specific Therapies"),Hr.a.createElement("ul",{className:"group__list group__list--vertical"},this.props.guidelines.selectedGuideline.diagnoses.sort((e,t)=>e.name<t.name?-1:1).filter(e=>"Specific Therapies"===e.diagnosisClass.name).map(e=>Hr.a.createElement(Ii,{key:e.id,inputName:"diagnosis",name:e.name,inputType:"radio",checked:e===this.props.guidelines.selectedGuideline.selectedDiagnosis,onChangeHandler:()=>this.selectDiagnosis(e)})))):null}})||oo;var co,uo;const fo=j()("infect:filterList");var po,ho=Mn((function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((uo=class extends Hr.a.Component{get bacteriaFilters(){const e=this.props.filterValues.getPropertiesForEntityType("bacterium");return fo("Bacteria filters are %o",e),e}render(){return Hr.a.createElement("div",{className:"filter"},this.bacteriaFilters.length>0&&Hr.a.createElement("div",null,this.props.mostUsedFilters.mostUsedFilters.length>0&&[Hr.a.createElement(ao,{identifier:"mostUsed",mostUsedFilters:this.props.mostUsedFilters,selectedFilters:this.props.selectedFilters,key:"content"}),Hr.a.createElement("hr",{className:"divider",key:"divider"})],this.props.guidelines&&this.props.guidelines.get().size>0&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement(lo,{identifier:"guidelines",additionalClassNames:"guidelines-selector-for-fabian-blue-background",guidelines:this.props.guidelines}),Hr.a.createElement("hr",{className:"divider"})),Hr.a.createElement(Ui,{identifier:"antibiotics",filterValues:this.props.filterValues,selectedFilters:this.props.selectedFilters}),Hr.a.createElement("hr",{className:"divider"}),Hr.a.createElement(qi,{identifier:"bacteria",filterValues:this.props.filterValues,selectedFilters:this.props.selectedFilters}),Hr.a.createElement("hr",{className:"divider"}),Hr.a.createElement(no,{identifier:"population",tenantConfig:this.props.tenantConfig,filterValues:this.props.filterValues,selectedFilters:this.props.selectedFilters,ageGroupStore:this.props.ageGroupStore,offsetFilters:this.props.offsetFilters})))}}).prototype,"bacteriaFilters",[T.m],Object.getOwnPropertyDescriptor(uo.prototype,"bacteriaFilters"),uo.prototype),co=uo))||co;let mo=Mn(po=class extends Hr.a.Component{render(){return Hr.a.createElement("li",{className:"group__list-item list-item"},Hr.a.createElement("div",{className:"label label--rounded"},Hr.a.createElement("p",{className:"label--smaller label--nomargin"},this.props.filter.property.niceName),Hr.a.createElement("p",{className:"label--bold label--nomargin"},this.props.filter.niceValue)),Hr.a.createElement("button",{onClick:()=>this.props.removeFilterHandler(this.props.filter),className:"button button--label"},Hr.a.createElement("span",null,"×")))}})||po;var go;let yo=Mn(go=class extends Hr.a.Component{_isVisible(){return!!this.props.selectedFilters.length}removeFilterHandler(e){this.props.removeFilter(e)}_getTranslation(e){const t=this.props.selectedFilters.length>1;switch(e){case"substanceClasses":return t?"Substance Classes":"Substance Class";case"antibiotics":return t?"Antibiotics":"Antibiotic";case"bacteria":return t?"Bacteria":"Bacterium";case"regions":return t?"Regions":"Region";case"ageGroups":return t?"Age Groups":"Age Group";case"diagnoses":return t?"Diagnoses":"Diagnosis";case"animals":return t?"Animals":"Animal";case"hospitalStatus":return t?"Patient Setting":"Patient Settings";case"sampleSource":return t?"Sample Sources":"Sample Source"}}render(){return this._isVisible()?Hr.a.createElement("div",{className:"group group--black-font"},Hr.a.createElement("h2",null,this._getTranslation(this.props.type)),Hr.a.createElement("ul",{className:"group__list"},this.props.selectedFilters.map(e=>Hr.a.createElement(mo,{type:this.props.type,key:`${e.property.name}-${e.value}`,filter:e,removeFilterHandler:this.removeFilterHandler.bind(this)})))):null}})||go;var vo;let bo=Mn(vo=class extends Hr.a.Component{removeFilter(e){this.props.selectedFilters.removeFilter(e)}render(){return Hr.a.createElement("div",{className:"top-navigation__active-filters groups"},Hr.a.createElement(yo,{type:"antibiotics",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.antibiotic)}),Hr.a.createElement(yo,{type:"substanceClasses",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.substanceClass)}),Hr.a.createElement(yo,{type:"bacteria",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.bacterium)}),Hr.a.createElement(yo,{type:"regions",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.region)}),Hr.a.createElement(yo,{type:"ageGroups",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.ageGroup)}),Hr.a.createElement(yo,{type:"animals",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.animal)}),Hr.a.createElement(yo,{type:"hospitalStatus",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.hospitalStatus)}),Hr.a.createElement(yo,{type:"sampleSource",removeFilter:this.removeFilter.bind(this),selectedFilters:this.props.selectedFilters.getFiltersByType(_t.sampleSource)}),this.props.selectedFilters.filters.length>1&&Hr.a.createElement("div",{className:"group group--black-font"},Hr.a.createElement("h2",null,Hr.a.createElement("strong",null,"Clear all filters")),Hr.a.createElement("button",{className:"button button--clearall",onClick:e=>this.props.selectedFilters.removeAllFilters()},Hr.a.createElement("span",null,"×"))))}})||vo;var wo,xo,_o,So;function Eo(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}function ko(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const Co=j()("infect:FilterListMenuComponent");let Oo=Mn((xo=class extends Hr.a.Component{constructor(...e){super(...e),Eo(this,"filterSections",_o,this),Eo(this,"currentlyActiveSection",So,this)}componentDidMount(){this._scrollElement=document.querySelector(".side-navigation__filters"),this._setupScrollListener()}updateCurrentlyActiveSection(e){this.currentlyActiveSection=e,Co("Updated currentlyActiveSection to %s",this.currentlyActiveSection)}_setupScrollListener(){this._scrollElement.addEventListener("scroll",()=>{this._scrollTimeout||(this._scrollTimeout=setTimeout(()=>{this._scrollTimeout=void 0;const e=this._scrollElement.getBoundingClientRect(),t=this.visibleButtons.map(t=>{const r=this._scrollElement.querySelector("#js-filter-list-"+t),n=e.top;return{topDiff:e.top+20-r.getBoundingClientRect().top,section:r,sectionName:t,top:n}}),r=t.filter(e=>e.topDiff>0);r.sort((e,t)=>e.topDiff<t.topDiff?-1:1),r.length||(r[0]=t.sort((e,t)=>e.top<t.top?1:-1)[0]),this.updateCurrentlyActiveSection(r[0].sectionName)},80))})}_getActiveClass(e){return e===this.currentlyActiveSection?"button--icon--active":""}_buttonClickHandler(e){const t=this._scrollElement.querySelector("#js-filter-list-"+e).getBoundingClientRect().top+this._scrollElement.scrollTop-this._scrollElement.getBoundingClientRect().top;try{this._scrollElement.scroll({top:t,behavior:"smooth"})}catch(e){this._scrollElement.scrollTop=t}}_getNiceName(e){return e.replace(/^\[a-z]/,e=>e.toUpperCase()).replace(/[A-Z]/g,e=>" "+e.toLowerCase())}get visibleButtons(){const e=this.filterSections.filter(e=>("mostUsed"!==e||0!==this.props.mostUsedFilters.mostUsedFilters.length)&&("guidelines"!==e||0!==this.props.guidelines.getAsArray().length));return Co("Visible buttons are %o",e),e}render(){return Hr.a.createElement("div",{className:"group group--vertical group--left-aligned js-filter-list-menu"},this.visibleButtons.map(e=>Hr.a.createElement("button",{key:e,title:this._getNiceName(e),className:"button button--icon button--icon--"+e+" "+this._getActiveClass(e),onClick:()=>this._buttonClickHandler(e)},Hr.a.createElement("svg",{"aria-hidden":"true"},Hr.a.createElement("use",{xlinkHref:"#icon_"+e})))))}},_o=ko(xo.prototype,"filterSections",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return["mostUsed","guidelines","antibiotics","bacteria","population"]}}),So=ko(xo.prototype,"currentlyActiveSection",[T.B],{configurable:!0,enumerable:!0,writable:!0,initializer:function(){return this.filterSections[1]}}),ko(xo.prototype,"updateCurrentlyActiveSection",[T.k],Object.getOwnPropertyDescriptor(xo.prototype,"updateCurrentlyActiveSection"),xo.prototype),ko(xo.prototype,"visibleButtons",[T.m],Object.getOwnPropertyDescriptor(xo.prototype,"visibleButtons"),xo.prototype),wo=xo))||wo;var Ao,To;let Po=Mn((function(e,t,r,n,i){var o={};Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null)}((To=class extends Hr.a.Component{get loading(){return this.props.stores.some(e=>e.status.identifier===z.loading)}render(){return Hr.a.createElement("div",{className:"resistanceMatrix__overlay "+(this.loading?"resistanceMatrix__overlay--active":"")},Hr.a.createElement("img",{src:"img/logo_spinner.svg"}))}}).prototype,"loading",[T.m],Object.getOwnPropertyDescriptor(To.prototype,"loading"),To.prototype),Ao=To))||Ao;var jo;let Fo=Mn(jo=class extends Hr.a.Component{render(){return Hr.a.createElement("li",{className:`group__list-item list-item result result--${this.props.item.type} ${this.props.isHighlighted?"result--active":""}`,onClick:this.props.item.toggle},Hr.a.createElement("div",{style:{opacity:this.props.item.isSelected()?1:0},className:"result__checkmark"}),Hr.a.createElement("div",{className:"label"},this.props.item.render()))}})||jo;var No,zo,Do;function Ro(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}j()("infect:FilterSearchSuggestions");let Io=Mn((zo=class extends Hr.a.Component{constructor(...e){super(...e),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 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Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}const $o=j()("infect:FilterSearch");let Uo=Mn((Lo=class extends Hr.a.Component{constructor(...e){super(...e),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 0})}(this,"searchTerm",Vo,this),this.handleSearchInputChange=this.handleSearchInputChange.bind(this),this.handleSearchInputKeyDown=this.handleSearchInputKeyDown.bind(this),this.searchInputHandlers=[]}get matches(){const e=this.props.searchMatrixFilters(this.searchTerm).slice(0,10);$o("Matrix matches are %o",e);const t=e.map(e=>({item:e,isSelected:()=>this.props.isMatrixFilterSelected(e),render:()=>($o("Render matrix filter item for %o",e),Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("p",{className:"result__item label--small label--gray label--nomargin"},e.property.entityType[0].toUpperCase()+e.property.entityType.substr(1)," – ",e.property.niceName),Hr.a.createElement("p",{className:"result__item label--bold label--larger label--nomargin"},e.niceValue))),toggle:()=>{$o("Toggle matrix filter %o",e),this.props.toggleMatrixFilter(e),this.resetSearchTerm()},key:`${e.property.entityType}-${e.property.name}-${e.value}`,type:"matrix"})),r=this.props.searchGuidelineFilters(this.searchTerm).slice(0,10);$o("Guideline matches are %o",r);const n=[...r.map(e=>({item:e,isSelected:()=>this.props.guidelines&&this.props.guidelines.selectedGuideline&&this.props.guidelines.selectedGuideline.selectedDiagnosis===e.diagnosis,render:()=>Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("p",{className:"result__item label--small  label--gray label--nomargin"},"Guideline – Diagnosis"),Hr.a.createElement("p",{className:"result__item label--bold label--larger label--nomargin"},e.name),e.synonym&&Hr.a.createElement("p",{className:"result__item label--small label--nomargin"},e.synonym)),toggle:()=>{const t=this.props.guidelines&&this.props.guidelines.selectedGuideline;t&&(t.selectedDiagnosis===e.diagnosis?t.selectDiagnosis():t.selectDiagnosis(e.diagnosis)),this.resetSearchTerm()},key:e.diagnosis.id,type:"guideline"})),...t];return $o("Enriched matches are %o",n),n}handleSearchInputChange(e){const{value:t}=e.target;$o("Filter input changed to 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Hr.a.createElement("span",null,Hr.a.createElement("button",{onClick:()=>this.startGuidedTour(),className:"button button--guide"},"Start guided tour"))}})||Ho;var qo,Jo,Ko;function Qo(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Yo=Mn((Jo=class extends Hr.a.Component{constructor(){super(),function(e,t,r,n){r&&Object.defineProperty(e,t,{enumerable:r.enumerable,configurable:r.configurable,writable:r.writable,value:r.initializer?r.initializer.call(n):void 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See some ",Hr.a.createElement("a",{href:"#",onClick:()=>this.showInfoOverlay(),className:"disclaimer__link"},"background information"),". If you have any questions, ",Hr.a.createElement("a",{href:"mailto:info@infect.info",className:"disclaimer__link"},"contact us"),". 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Click on a substance class to add or remove the corresponding filter to the matrix.</p>\n\t\t\t\t\t\t\t\t<div class="tour-image-wrapper tour-image-wrapper--small-devices-only tour-image-wrapper--substance-classes">\n\t\t\t\t\t\t\t\t\t<img class="image image--fluid" src="../img/guidedTour/substance-classes.jpg"/>\n\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t</div>'},{element:document.querySelector(".js-side-navigation"),intro:'<div class="introjs-tooltip__layout introjs-tooltip__layout--column">\n\t\t\t\t\t\t\t\t<p>Use the dark filter area on the left to change the data displayed in the matrix. If you add filters for antibiotics, substances or bacteria, rows or columns will be hidden. If you add population or offset filters, the contents of the matrix will change.</p>\n\t\t\t\t\t\t\t\t<div class="tour-image-wrapper tour-image-wrapper--small-devices-only tour-image-wrapper--filters">\n\t\t\t\t\t\t\t\t\t<img class="image image--fluid" src="../img/guidedTour/filters.jpg"/>\n\t\t\t\t\t\t\t\t</div>\n\t\t\t\t\t\t\t</div>'},{element:document.querySelector(".js-filter-search-input"),intro:'<div class="introjs-tooltip__layout introjs-tooltip__layout--column">\n\t\t\t\t\t\t\t\t<p>Quickly find any filter values. Enter «Amox» to quickly filter by Amoxicillin or «East» to display data for the East region. 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Hr.a.createElement("div",{className:"drawer__inner"},Hr.a.createElement("div",{className:"drawer__teaser",onClick:this.toggleDrawer},Hr.a.createElement("div",{className:"drawer__teaser-flap"},Hr.a.createElement("div",{className:"drawer__teaser-subtitle"},"Susceptibility"),Hr.a.createElement("div",{className:"drawer__teaser-title"},this.props.resistance.bacterium.shortName," →"," ",this.props.resistance.antibiotic.name))),Hr.a.createElement("div",{className:"drawer__fixed"},Hr.a.createElement("h1",null,"Susceptibility of ",this.props.resistance.bacterium.name," to"," ",this.props.resistance.antibiotic.name)),Hr.a.createElement("div",{className:"drawer__scrollable"},Hr.a.createElement("div",{className:"drawer__scrollable-inner"},this.selectedPopulationFilters.length>0&&Hr.a.createElement("div",{className:"drawer__section drawer__section--selectedFilters"},Hr.a.createElement("h2",null,"Data Filtered 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0!==e.susceptible&&Hr.a.createElement(Hr.a.Fragment,null,"(N=",e.susceptible,")"))),Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"95% Confidence Interval"),Hr.a.createElement("td",{className:"drawer__value-value"},Math.round(100*(1-e.confidenceInterval[1])),"–",Math.round(100*(1-e.confidenceInterval[0])),"%")),void 0!==e.intermediate&&Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"Proportion Intermediate"),Hr.a.createElement("td",{className:"drawer__value-value"},Math.round(e.intermediate/e.sampleSize*100),"%"," ","(N=",e.intermediate,")")),void 0!==e.resistant&&Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"Proportion Resistant"),Hr.a.createElement("td",{className:"drawer__value-value"},Math.round(e.resistant/e.sampleSize*100),"%"," ","(N=",e.resistant,")")),Hr.a.createElement("tr",{className:"drawer__value drawer__value--bold"},Hr.a.createElement("td",{className:"drawer__value-label"},"Number of Isolates (N)"),Hr.a.createElement("td",{className:"drawer__value-value"},e.sampleSize))))),e.type===ve.discDiffusion&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h2",null,"Quantitative Data (Disc Diffusion)"),Hr.a.createElement("table",{className:"drawer__values"},Hr.a.createElement("tbody",null,Hr.a.createElement("tr",{className:"drawer__value drawer__value--bold"},Hr.a.createElement("td",{className:"drawer__value-label"},"Testing Method"),Hr.a.createElement("td",{className:"drawer__value-value"},"Disc Diffusion")),Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"Number of Isolates (N)"),Hr.a.createElement("td",{className:"drawer__value-value"},e.sampleSize)))),void 0===e.quantitativeData.percentileValue&&Hr.a.createElement("p",null,"⌛"),void 0!==e.quantitativeData.percentileValue&&Hr.a.createElement(Pa,{data:e.quantitativeData.slots,xAxisLabel:"DD (mm)"})),e.type===ve.mic&&Hr.a.createElement(Hr.a.Fragment,null,Hr.a.createElement("h2",null,"Quantitative Data (Microdilution)"),Hr.a.createElement("table",{className:"drawer__values"},Hr.a.createElement("tbody",null,Hr.a.createElement("tr",{className:"drawer__value drawer__value--bold"},Hr.a.createElement("td",{className:"drawer__value-label"},"Testing Method"),Hr.a.createElement("td",{className:"drawer__value-value"},"Microdilution")),void 0===e.quantitativeData.percentileValue&&Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"MIC",Hr.a.createElement("sub",null,"90")),Hr.a.createElement("td",{className:"drawer__value-value"},"⌛")),void 0!==e.quantitativeData.percentileValue&&Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"MIC",Hr.a.createElement("sub",null,"90")),Hr.a.createElement("td",{className:"drawer__value-value"},e.quantitativeData.percentileValue," mg/l")),Hr.a.createElement("tr",{className:"drawer__value"},Hr.a.createElement("td",{className:"drawer__value-label"},"Number of Isolates (N)"),Hr.a.createElement("td",{className:"drawer__value-value"},e.sampleSize)))),void 0===e.quantitativeData.percentileValue&&Hr.a.createElement("p",null,"⌛"),void 0!==e.quantitativeData.percentileValue&&Hr.a.createElement(Pa,{data:e.quantitativeData.slots,xAxisLabel:"MIC (mg/l)",mic90:e.quantitativeData.percentileValue,scale:"log"}))))))))}}).prototype,"selectedPopulationFilters",[T.m],Object.getOwnPropertyDescriptor(Fa.prototype,"selectedPopulationFilters"),Fa.prototype),ja=Fa))||ja;var za;const Da=j()("infect:Drawer");let Ra=Mn(za=class extends Hr.a.Component{constructor(...e){super(...e),this.closeDrawer=this.closeDrawer.bind(this)}closeDrawer(){Da("Close button clicked"),this.props.drawerViewModel.close()}getVisibilityClass(){return this.props.drawerViewModel&&this.props.drawerViewModel.isOpen?"open":"hidden"}getContentClass(){const e=[];return this.props.drawerViewModel&&this.props.drawerViewModel.content||e.push("is-empty"),e.push(this.props.drawerViewModel.contentType),e.join(" ")}render(){return Hr.a.createElement("div",{className:`drawer ${this.getVisibilityClass()} ${this.getContentClass()}`},Hr.a.createElement("button",{onClick:this.closeDrawer,className:"drawer__close-button button button--close-drawer"},"×"),this.props.drawerViewModel&&"guideline"===this.props.drawerViewModel.contentType&&Hr.a.createElement(Ca,{content:this.props.drawerViewModel.content,drawerViewModel:this.props.drawerViewModel,app:this.props.app}),this.props.drawerViewModel&&"resistance"===this.props.drawerViewModel.contentType&&Hr.a.createElement(Na,{drawerViewModel:this.props.drawerViewModel,resistance:this.props.drawerViewModel.content,selectedFilters:this.props.app.selectedFilters}))}})||za;var Ia,Ma;function La(e,t,r,n,i){var o={};return Object.keys(n).forEach((function(e){o[e]=n[e]})),o.enumerable=!!o.enumerable,o.configurable=!!o.configurable,("value"in o||o.initializer)&&(o.writable=!0),o=r.slice().reverse().reduce((function(r,n){return n(e,t,r)||r}),o),i&&void 0!==o.initializer&&(o.value=o.initializer?o.initializer.call(i):void 0,o.initializer=void 0),void 0===o.initializer&&(Object.defineProperty(e,t,o),o=null),o}let Va=Mn((La((Ma=class extends Hr.a.Component{constructor(...e){super(...e),this.removeSelectedDiagnosis=this.removeSelectedDiagnosis.bind(this)}removeSelectedDiagnosis(){this.props.guidelines.selectedGuideline.selectDiagnosis()}get selectedDiagnosis(){return this.props.guidelines&&this.props.guidelines.selectedGuideline&&this.props.guidelines.selectedGuideline.selectedDiagnosis}get visible(){return!!this.selectedDiagnosis}render(){return this.visible?Hr.a.createElement("div",{className:"group group--black-font"},Hr.a.createElement("h2",null,"Guideline"),Hr.a.createElement("ul",{className:"group__list"},Hr.a.createElement("li",{className:"group__list-item group__list-item--guidelines list-item list-item--guidelines"},Hr.a.createElement("div",{className:"label label--rounded label--guidelines"},Hr.a.createElement("p",{className:"label--smaller label--nomargin"},"Diagnosis"),Hr.a.createElement("p",{className:"label--bold label--nomargin"},this.selectedDiagnosis.name)),Hr.a.createElement("button",{onClick:this.removeSelectedDiagnosis,className:"button button--label"},Hr.a.createElement("span",null,"×"))))):null}}).prototype,"selectedDiagnosis",[T.m],Object.getOwnPropertyDescriptor(Ma.prototype,"selectedDiagnosis"),Ma.prototype),La(Ma.prototype,"visible",[T.m],Object.getOwnPropertyDescriptor(Ma.prototype,"visible"),Ma.prototype),Ia=Ma))||Ia;var Ba;let $a=Mn(Ba=class extends Hr.a.Component{getLogoURL(){const e=this.props.tenantConfig.getConfig("frontend");return e&&e.userInterface&&e.userInterface.logoUrl}render(){return Hr.a.createElement(Hr.a.Fragment,null,!this.getLogoURL()&&null,this.getLogoURL()&&Hr.a.createElement("img",{className:"c-logo__vector-image",src:this.getLogoURL()}))}})||Ba;
/*!
 * css-vars-ponyfill
 * v2.4.3
 * https://jhildenbiddle.github.io/css-vars-ponyfill/
 * (c) 2018-2021 John Hildenbiddle <http://hildenbiddle.com>
 * MIT license
 */function Ua(){return(Ua=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var r=arguments[t];for(var n in r)Object.prototype.hasOwnProperty.call(r,n)&&(e[n]=r[n])}return e}).apply(this,arguments)}
/*!
 * get-css-data
 * v2.0.0
 * https://github.com/jhildenbiddle/get-css-data
 * (c) 2018-2021 John Hildenbiddle <http://hildenbiddle.com>
 * MIT license
 */function Ha(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},r={mimeType:t.mimeType||null,onBeforeSend:t.onBeforeSend||Function.prototype,onSuccess:t.onSuccess||Function.prototype,onError:t.onError||Function.prototype,onComplete:t.onComplete||Function.prototype},n=Array.isArray(e)?e:[e],i=Array.apply(null,Array(n.length)).map((function(e){return null}));function o(e){var t=e&&"<"===e.trim().charAt(0);return e&&!t}function a(e,t){r.onError(e,n[t],t)}function s(e,t){var o=r.onSuccess(e,n[t],t);e=!1===o?"":o||e,i[t]=e,-1===i.indexOf(null)&&r.onComplete(i)}var l=document.createElement("a");n.forEach((function(e,t){if(l.setAttribute("href",e),l.href=String(l.href),Boolean(document.all&&!window.atob)&&l.host.split(":")[0]!==location.host.split(":")[0]){if(l.protocol===location.protocol){var n=new XDomainRequest;n.open("GET",e),n.timeout=0,n.onprogress=Function.prototype,n.ontimeout=Function.prototype,n.onload=function(){o(n.responseText)?s(n.responseText,t):a(n,t)},n.onerror=function(e){a(n,t)},setTimeout((function(){n.send()}),0)}else console.warn("Internet Explorer 9 Cross-Origin (CORS) requests must use the same protocol (".concat(e,")")),a(null,t)}else{var i=new XMLHttpRequest;i.open("GET",e),r.mimeType&&i.overrideMimeType&&i.overrideMimeType(r.mimeType),r.onBeforeSend(i,e,t),i.onreadystatechange=function(){4===i.readyState&&(i.status<400&&o(i.responseText)||0===i.status&&o(i.responseText)?s(i.responseText,t):a(i,t))},i.send()}}))}
/**
 * Gets CSS data from <style> and <link> nodes (including @imports), then
 * returns data in order processed by DOM. Allows specifying nodes to
 * include/exclude and filtering CSS data using RegEx.
 *
 * @preserve
 * @param {object}   [options] The options object
 * @param {object}   [options.rootElement=document] Root element to traverse for
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 * @param {string}   [options.include] CSS selector matching <link> and <style>
 *                   nodes to include
 * @param {string}   [options.exclude] CSS selector matching <link> and <style>
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 * @param {object}   [options.filter] Regular expression used to filter node CSS
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 *     exclude     : '[href="skip.css"]',
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/**
 * Fetches, parses, and transforms CSS custom properties from specified
 * <style> and <link> elements into static values, then appends a new <style>
 * element with static values to the DOM to provide CSS custom property
 * compatibility for legacy browsers. Also provides a single interface for
 * live updates of runtime values in both modern and legacy browsers.
 *
 * @preserve
 * @param {object}   [options] Options object
 * @param {object}   [options.rootElement=document] Root element to traverse for
 *                   <link> and <style> nodes
 * @param {boolean}  [options.shadowDOM=false] Determines if shadow DOM <link>
 *                   and <style> nodes will be processed.
 * @param {string}   [options.include="style,link[rel=stylesheet]"] CSS selector
 *                   matching <link re="stylesheet"> and <style> nodes to
 *                   process
 * @param {string}   [options.exclude] CSS selector matching <link
 *                   rel="stylehseet"> and <style> nodes to exclude from those
 *                   matches by options.include
 * @param {object}   [options.variables] A map of custom property name/value
 *                   pairs. Property names can omit or include the leading
 *                   double-hyphen (—), and values specified will override
 *                   previous values
 * @param {boolean}  [options.onlyLegacy=true] Determines if the ponyfill will
 *                   only generate legacy-compatible CSS in browsers that lack
 *                   native support (i.e., legacy browsers)
 * @param {boolean}  [options.preserveStatic=true] Determines if CSS
 *                   declarations that do not reference a custom property will
 *                   be preserved in the transformed CSS
 * @param {boolean}  [options.preserveVars=false] Determines if CSS custom
 *                   property declarations will be preserved in the transformed
 *                   CSS
 * @param {boolean}  [options.silent=false] Determines if warning and error
 *                   messages will be displayed on the console
 * @param {boolean}  [options.updateDOM=true] Determines if the ponyfill will
 *                   update the DOM after processing CSS custom properties
 * @param {boolean}  [options.updateURLs=true] Determines if relative url()
 *                   paths will be converted to absolute urls in external CSS
 * @param {boolean}  [options.watch=false] Determines if a MutationObserver will
 *                   be created that will execute the ponyfill when a <link> or
 *                   <style> DOM mutation is observed
 * @param {function} [options.onBeforeSend] Callback before XHR is sent. Passes
 *                   1) the XHR object, 2) source node reference, and 3) the
 *                   source URL as arguments
 * @param {function} [options.onError] Callback after a CSS parsing error has
 *                   occurred or an XHR request has failed. Passes 1) an error
 *                   message, and 2) source node reference, 3) xhr, and 4 url as
 *                   arguments.
 * @param {function} [options.onWarning] Callback after each CSS parsing warning
 *                   has occurred. Passes 1) a warning message as an argument.
 * @param {function} [options.onSuccess] Callback after CSS data has been
 *                   collected from each node and before CSS custom properties
 *                   have been transformed. Allows modifying the CSS data before
 *                   it is transformed by returning any string value (or false
 *                   to skip). Passes 1) CSS text, 2) source node reference, and
 *                   3) the source URL as arguments.
 * @param {function} [options.onComplete] Callback after all CSS has been
 *                   processed, legacy-compatible CSS has been generated, and
 *                   (optionally) the DOM has been updated. Passes 1) a CSS
 *                   string with CSS variable values resolved, 2) an array of
 *                   output <style> node references that have been appended to
 *                   the DOM, 3) an object containing all custom properies names
 *                   and values, and 4) the ponyfill execution time in
 *                   milliseconds.
 * @param {function} [options.onFinally] Callback in modern and legacy browsers
 *                   after the ponyfill has finished all tasks. Passes 1) a
 *                   boolean indicating if the last ponyfill call resulted in a
 *                   style change, 2) a boolean indicating if the current
 *                   browser provides native support for CSS custom properties,
 *                   and 3) the ponyfill execution time in milliseconds.
 * @example
 *
 *   cssVars({
 *     rootElement   : document,
 *     shadowDOM     : false,
 *     include       : 'style,link[rel="stylesheet"]',
 *     exclude       : '',
 *     variables     : {},
 *     onlyLegacy    : true,
 *     preserveStatic: true,
 *     preserveVars  : false,
 *     silent        : false,
 *     updateDOM     : true,
 *     updateURLs    : true,
 *     watch         : false,
 *     onBeforeSend(xhr, node, url) {},
 *     onError(message, node, xhr, url) {},
 *     onWarning(message) {},
 *     onSuccess(cssText, node, url) {},
 *     onComplete(cssText, styleNode, cssVariables, benchmark) {},
 *     onFinally(hasChanged, hasNativeSupport, benchmark)
 *   });
 */
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