UNPKG

@gmod/cram

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read CRAM files with pure Javascript

522 lines (435 loc) 12 kB
/* eslint-disable no-var */ // @ts-nocheck /* * Copyright (c) 2019,2020 Genome Research Ltd. * Author(s): James Bonfield * * Redistribution and use in source and binary forms, with or without * modification, are permitted provided that the following conditions are met: * * 1. Redistributions of source code must retain the above copyright notice, * this list of conditions and the following disclaimer. * * 2. Redistributions in binary form must reproduce the above * copyright notice, this list of conditions and the following * disclaimer in the documentation and/or other materials provided * with the distribution. * * 3. Neither the names Genome Research Ltd and Wellcome Trust Sanger * Institute nor the names of its contributors may be used to endorse * or promote products derived from this software without specific * prior written permission. * * THIS SOFTWARE IS PROVIDED BY GENOME RESEARCH LTD AND CONTRIBUTORS "AS * IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED * TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A * PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL GENOME RESEARCH * LTD OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, * SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT * LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, * DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY * THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT * (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE * OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. */ import IOStream from './iostream.ts' // ---------------------------------------------------------------------- // rANS primitives itself // // RansGet* is decoder side function RansGetCumulativeFreq(R, bits) { return R & ((1 << bits) - 1) } function RansGetSymbolFromFreq(C, f) { // NOTE: Inefficient. // In practice we would implement this via a precomputed // lookup table C2S[f]; see RansBuildC2S below. let s = 0 while (f >= C[s + 1]) { s++ } // console.error(f, C, s) return s } function RansBuildC2S(C, bits) { const max = 1 << bits const C2S = new Array(max) let s = 0 for (let f = 0; f < max; f++) { while (f >= C[s + 1]) { s++ } C2S[f] = s } return C2S } function RansAdvanceStep(R, c, f, bits) { return f * (R >> bits) + (R & ((1 << bits) - 1)) - c } function RansRenorm(src, R) { if (R < 1 << 15) { R = (R << 16) + src.ReadUint16() } return R } function DecodeRLEMeta(src, N) { const u_meta_len = src.ReadUint7() const rle_len = src.ReadUint7() // Decode RLE lengths if (u_meta_len & 1) { var rle_meta = src.ReadData((u_meta_len - 1) / 2) } else { const comp_meta_len = src.ReadUint7() var rle_meta = src.ReadData(comp_meta_len) rle_meta = RansDecode0(new IOStream(rle_meta), u_meta_len / 2, N) } // Decode list of symbols for which RLE lengths are applied var rle_meta = new IOStream(rle_meta) const L = new Array(256) let n = rle_meta.ReadByte() if (n == 0) { n = 256 } for (let i = 0; i < n; i++) { L[rle_meta.ReadByte()] = 1 } return [L, rle_meta, rle_len] } function DecodeRLE(buf, L, rle_meta, len) { const src = new IOStream(buf) const out = new Uint8Array(len) // Expand up buf+meta to out; i = buf index, j = out index let j = 0 for (let i = 0; j < len; i++) { const sym = buf[i] if (L[sym]) { const run = rle_meta.ReadUint7() for (let r = 0; r <= run; r++) { out[j++] = sym } } else { out[j++] = sym } } return out } // Pack meta data is the number and value of distinct symbols plus // the length of the packed byte stream. function DecodePackMeta(src) { const nsym = src.ReadByte() const P = new Array(nsym) for (let i = 0; i < nsym; i++) { P[i] = src.ReadByte() } const len = src.ReadUint7() return [P, nsym, len] } // Extract bits from src producing output of length len. // Nsym is number of distinct symbols used. function DecodePack(data, P, nsym, len) { const out = new Uint8Array(len) let j = 0 // Constant value if (nsym <= 1) { for (var i = 0; i < len; i++) { out[i] = P[0] } } // 1 bit per value else if (nsym <= 2) { for (i = 0; i < len; i++) { if (i % 8 == 0) { var v = data[j++] } out[i] = P[v & 1] v >>= 1 } } // 2 bits per value else if (nsym <= 4) { for (i = 0; i < len; i++) { if (i % 4 == 0) { var v = data[j++] } out[i] = P[v & 3] v >>= 2 } } // 4 bits per value else if (nsym <= 16) { for (i = 0; i < len; i++) { if (i % 2 == 0) { var v = data[j++] } out[i] = P[v & 15] v >>= 4 } } return out } function RansDecodeStripe(src, len) { const N = src.ReadByte() // Retrieve lengths const clen = new Array(N) const ulen = new Array(N) for (var j = 0; j < N; j++) { clen[j] = src.ReadUint7() } // Decode streams const T = new Array(N) for (var j = 0; j < N; j++) { ulen[j] = Math.floor(len / N) + (len % N > j) T[j] = RansDecodeStream(src, ulen[j]) } // Transpose const out = new Uint8Array(len) for (var j = 0; j < N; j++) { for (let i = 0; i < ulen[j]; i++) { out[i * N + j] = T[j][i] } } return out } // ---------------------------------------------------------------------- // Main rANS entry function: decodes a compressed src and // returns the uncompressed buffer. export function decode(src) { const stream = new IOStream(src) return RansDecodeStream(stream, 0) } function RansDecodeStream(stream, n_out) { const format = stream.ReadByte() const order = format & 1 const x32 = format & 4 const stripe = format & 8 const nosz = format & 16 const cat = format & 32 const rle = format & 64 const pack = format & 128 const Nway = x32 ? 32 : 4 if (!nosz) { n_out = stream.ReadUint7() } // N-way interleaving if (stripe) { return RansDecodeStripe(stream, n_out) } // Bit packing if (pack) { var pack_len = n_out var [P, nsym, n_out] = DecodePackMeta(stream) } // Run length encoding if (rle) { var rle_len = n_out var [L, rle_meta, n_out] = DecodeRLEMeta(stream, Nway) } // Uncompress data (all, packed or run literals) if (cat) { var buf = stream.ReadData(n_out) } else if (order == 0) { var buf = RansDecode0(stream, n_out, Nway) } else { var buf = RansDecode1(stream, n_out, Nway) } // Apply expansion transforms if (rle) { buf = DecodeRLE(buf, L, rle_meta, rle_len) } if (pack) { buf = DecodePack(buf, P, nsym, pack_len) } return buf } // ---------------------------------------------------------------------- // Order-0 decoder function ReadAlphabet(src) { const A = new Array(256) for (let i = 0; i < 256; i++) { A[i] = 0 } let rle = 0 let sym = src.ReadByte() let last_sym = sym do { A[sym] = 1 if (rle > 0) { rle-- sym++ } else { sym = src.ReadByte() if (sym == last_sym + 1) { rle = src.ReadByte() } } last_sym = sym } while (sym != 0) return A } // Decode a single table of order-0 frequences, // filling out the F and C arrays. function ReadFrequencies0(src, F, C) { // Initialise; not in the specification - implicit? for (var i = 0; i < 256; i++) { F[i] = 0 } // Fetch alphabet const A = ReadAlphabet(src) // Fetch frequencies for the symbols listed in our alphabet for (var i = 0; i < 256; i++) { if (A[i] > 0) { F[i] = src.ReadUint7() } } NormaliseFrequencies0_Shift(F, 12) // Compute C[] from F[] C[0] = 0 for (var i = 0; i <= 255; i++) { C[i + 1] = C[i] + F[i] } } function RansDecode0(src, nbytes, N) { // Decode frequencies const F = new Array(256) const C = new Array(256) ReadFrequencies0(src, F, C) // Fast lookup to avoid slow RansGetSymbolFromFreq const C2S = RansBuildC2S(C, 12) // Initialise rANS state const R = new Array(N) for (var i = 0; i < N; i++) { R[i] = src.ReadUint32() } // Main decode loop const output = new Uint8Array(nbytes) for (var i = 0; i < nbytes; i++) { const ix = i & (N - 1) // equiv to i%N as N is power of 2 const f = RansGetCumulativeFreq(R[ix], 12) const s = C2S[f] // Equiv to RansGetSymbolFromFreq(C, f); output[i] = s R[ix] = RansAdvanceStep(R[ix], C[s], F[s], 12) R[ix] = RansRenorm(src, R[ix]) } // Main decode loop return output } function NormaliseFrequencies0_Shift(F, bits) { // Compute total and number of bits to shift by let tot = 0 for (var i = 0; i < 256; i++) { tot += F[i] } if (tot == 0 || tot == 1 << bits) { return } let shift = 0 while (tot < 1 << bits) { tot *= 2 shift++ } // Scale total of frequencies to (1<<bits) for (var i = 0; i < 256; i++) { F[i] <<= shift } } // ---------------------------------------------------------------------- // Order-1 decoder // Decode a table of order-1 frequences, // filling out the F and C arrays. function ReadFrequencies1(src, F, C, shift) { // Initialise; not in the specification - implicit? for (var i = 0; i < 256; i++) { F[i] = new Array(256) C[i] = new Array(256) for (var j = 0; j < 256; j++) { F[i][j] = 0 } } // Fetch alphabet const A = ReadAlphabet(src) // Read F[] for (var i = 0; i < 256; i++) { if (!A[i]) { continue } let run = 0 for (var j = 0; j < 256; j++) { if (!A[j]) { continue } if (run > 0) { run-- } else { F[i][j] = src.ReadUint7() if (F[i][j] == 0) { run = src.ReadByte() } } } NormaliseFrequencies0_Shift(F[i], shift) // Compute C[] from F[] C[i][0] = 0 for (var j = 0; j < 256; j++) { C[i][j + 1] = C[i][j] + F[i][j] } } } function RansDecode1(src, nbytes, N) { // FIXME: this bit is missing from the RansDecode0 pseudocode. var comp = src.ReadByte() const shift = comp >> 4 var freq_src = src if (comp & 1) { const ulen = src.ReadUint7() const clen = src.ReadUint7() var comp = new IOStream(src.ReadData(clen)) var freq_src = new IOStream(RansDecode0(comp, ulen, 4)) } // Decode frequencies const F = new Array(256) const C = new Array(256) ReadFrequencies1(freq_src, F, C, shift) // Fast lookup to avoid slow RansGetSymbolFromFreq const C2S = new Array(256) for ( var i = 0; i < 256; i++ // Could do only for symbols in alphabet? ) { C2S[i] = RansBuildC2S(C[i], shift) } // Initialise rANS state const R = new Array(N) const L = new Array(N) for (var j = 0; j < N; j++) { R[j] = src.ReadUint32() L[j] = 0 } // Main decode loop const output = new Uint8Array(nbytes) const nbytesx = Math.floor(nbytes / N) for (var i = 0; i < nbytesx; i++) { for (var j = 0; j < N; j++) { var f = RansGetCumulativeFreq(R[j], shift) // var s = RansGetSymbolFromFreq(C[L[j]], f); var s = C2S[L[j]][f] // Precomputed version of above output[i + j * nbytesx] = s R[j] = RansAdvanceStep(R[j], C[L[j]][s], F[L[j]][s], shift) R[j] = RansRenorm(src, R[j]) L[j] = s } } // Now deal with the remainder if buffer size is not a multiple of N, // using the last rANS state exclusively. (It'd have been nice to have // designed this to just act as if we kept going with a bail out.) i = N * i while (i < nbytes) { var f = RansGetCumulativeFreq(R[N - 1], shift) var s = RansGetSymbolFromFreq(C[L[N - 1]], f) output[i++] = s R[N - 1] = RansAdvanceStep(R[N - 1], C[L[N - 1]][s], F[L[N - 1]][s], shift) R[N - 1] = RansRenorm(src, R[N - 1]) L[N - 1] = s } return output }